PULSE WAVE VELOCITY AND ITS USEFULNESS IN ESTIMATION OF HYPERTENSION


Jayanthi Thiruvengadam, Anburajan M

Abstract


Objective: “Arterial vessel wall stiffness” is an important determinant of cardiovascular disease (CVD). Prolonged hypertension causes deterioration
in the blood vessel elasticity. Hypertension can be prevented by early diagnosis. Pulse wave velocity (PWV) is the direct method for assessing the
arterial stiffness. Though numerous studies have been performed, the definite limit is not declared to evaluate CVD based on the threshold of PWV
for South Indian population.

Methods: In this study, we included a total of 246 healthy controls and 14 hypertensive patients. Mechanical variables of blood flow are measured
using PC-based periScope Device (Genesis Medical Systems, India). The following variables are measured from the normal controls and hypertensive
patients: (i) Heart rate (bpm), (ii) systolic blood pressure (SBP) (mmHg), (iii) diastolic blood pressure (DBP) (mmHg), (iv) brachial PWV
(baPWV) (cm/s), (v) carotid-femoral PWV (C-F PWV) (cm/s), (vi) pulse pressure (mm Hg), (vii) arterial stiffness index (ASI) (mmHg), (viii) anklebrachial
index (ABI), (ix) aortic SBP and DBP (mmHg), and (x) aortic augmentation pressure (mmHg).

Results: The study shows the deterioration in the vessel elasticity with advancing age in both men and women. In the normal men population studied
(n=135), an increase in SBP from a young age to older age was 3.7%, likewise in women (n=111), it was 12%. A standard cutoff value of 1738 cm/s
for baPWV and 1215 cm/s for C-F PWV was calculated from the combined group of known hypertensive patients and age- and sex-matched normal
controls.

Conclusion: Thus, the PWV and the variables derived from it can be used for evaluating the status of blood vessels noninvasively.

Keywords: Vascular stiffness, Pulse wave velocity, Gender, Carotid-femoral, Hypertensive.


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References


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About this article

Title

PULSE WAVE VELOCITY AND ITS USEFULNESS IN ESTIMATION OF HYPERTENSION

DOI

10.22159/ajpcr.2017.v10i4.16447

Date

01-04-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 4 April 2017 Page: 181-187

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

31 Views | 40 Downloads

Authors & Affiliations

Jayanthi Thiruvengadam
SRM University
India

Anburajan M

 

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