FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING TABLET USING HIBISCUS ROSA-SINENSIS MUCILAGE


Rohini Sachin More, Kharwade Rs, Mahajan Un

Abstract


ABSTRACT
Objective: Domperidone is a synthetic benzimidazole compound that acts as a dopamine D2 receptor antagonist. The main aim of this study was to
optimize and evaluate the floating tablets of domperidone that prolongs the gastric residence time using Hibiscus rosa-sinensis mucilage.
Methods: The directly compressible floating tablets of domperidone were formulated using varying amount of hydroxypropyl methylcellulose
K100 M, carbopol 934P and H. rosa-sinensis mucilage. The effervescent components sodium bicarbonate is used for the generation of CO2 gas. The
prepared tablets were evaluated for physicochemical parameters and found to be within range, viz., hardness, swelling index, floating capacity,
thickness, and weight variation. Further, tablets were evaluated for in vitro release characteristics. The concentration of H. rosa-sinensis mucilage with
a gas-generating agent was optimized to get the sustained release of domperidone.
Result: The % cumulative drug release of all formulation from F1 to F6 was within the range of 81.37% to 98.62% for 18 hrs. The release kinetics of
all the dosage forms was calculated using zero order, first order, Higuchi, and Korsmeyer–Peppas. It concludes that the release followed zero order
release, whereas the correlation coefficient (r2 value) was higher for zero order release. The release mechanism follows Higuchi model, Korsmeyer-
Peppas model, and non-Fickian diffusion.
Conclusion: As a result of this study, it may be concluded that the floating tablets using H. rosa-sinensis mucilage in optimized concentrations can
be used to increase the gastric retention time of the dissolution fluid in the stomach to deliver the drug in a sustained manner. Furthermore, from
1 month stability data shows no significant change compared to initial result.
Keywords: Floating drug delivery, Hibiscus rosa-sinensis mucilage, Domperidone.


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References


REFERENCES

Rouge N, Leroux JH, Cole ET, Doelker E, Buri P. Prevention of the sticking tendency of buoyant minitablets filled into hard gelatine capsules. Eur J Pharm Biopharm 1997;43(2):165-71.

Lee JH, Park TG, Choi HK. Development of oral drug delivery system using floating microspheres. J Microencapsul 1999;16(6):715-29.

Robinson JR, Eriksen SP. Theoretical formulation of sustained-release dosage forms. J Pharm Sci 1966;55(11):1254-63.

Baumgartner S, Kristl J, Vrecer F, Vodopivec P, Zorko B. Optimisation of floating matrix tablets and evaluation of their gastric residence time. Int J Pharm 2000;195(1-2):125-35.

Manmohan SJ, Anshita G, Abhishek KS. Development and evaluation of mucoadhesive sustained release tablet using Tamarindus indica Gum. Asian J Res Pharm Sci 2014;4(2):77-82.

Sajid KS, Kamran AC, Ullah R, Hussain Z, Sadozai KM, Rahman US, et al. Formulation development and evaluation of domperidone sustained release matrix tablets by two different methods using guar gum as a sustaining agent. World Appl Sci J 2013;25(12):1704-12.

Khan MA, Saeed M, Badshah A, Muhammad N, Khan J, Khan FA, et al. Design, formulation, optimization and evaluation of sustained release tablets of domperidone. Afr J Pharm Pharmacol 2011;5(16):1882-7.

Ameena K, Dilip C, Saraswathi R, Krishnan PN, Sankar C, Simi SP. Isolation of the mucilages from Hibiscus rosa-sinensis Linn. And Okra (Abelmoschus esculentus Linn.) And studies of the binding effects of the mucilages. Asian Pac J Trop Med 2010;3(7):539-43.

Senapati K, Srinatha A, Pandit JK. In vitro release characteristics of matrix tablets: Study of Karaya gum and Guar gum as release modulators. Indian J Pharm Sci 2006;68(6):824-6.

Girish KJ, Dhiren PS, Vipul DP, Vineet CJ. Gums and mucilages: Versatile excipients for pharmaceutical formulations. Asian J Pharm Sci 2009;4(5):309-23.

Streubel A, Siepmann J, Bodmeier R. Floating matrix tablets based on low density foam powder: Effects of formulation and processing parameters on drug release. Eur J Pharm Sci 2003;18(1):37-45.

Krögel I, Bodmeier R. Development of a multifunctional matrix drug delivery system surrounded by an impermeable cylinder. J Control Release 1999;61(1-2):43-50.

Khullar P, Khar RK, Agarwal SP. Evaluation of hydrogel-based controlled-release niacin tablets. Drug Dev Ind Pharm 1998;24(5):479-83.

Chavanpatil M, Jain P, Chaudhari S, Shear R, Vavia P. Development of sustained release gastro-retentive drug delivery system for ofloxacin: In vitro and in vivo evaluation. Int J Pharm 2005;304(1-2):178-84.

Dey S, Dutta S, Mazumder B. Formulation and evaluation of floating matrix tablet of atenolol for gastro-retentive drug delivery. Int J Pharm Pharm Sci 2012;4(3):433-7.

Shunmuga VJ, Lakshmanan P, Basker RD. Formulation development and characterization of Hibiscus rosa-sinesis dry leaves mucilage as smart polymer for pharmaceutical use. Int J Appl Res Nat Prod 2015;8(2):28-36.

Sowjanya K, Deepthi KS, Bharathi A. Formulation and evaluation of gastro-retentive floating matrix tablets of nevirapine. Int J Pharm Pharm Sci 2012;4(5):368-75.

Higuchi T. Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci 1963;52:1145-9.

Peppas NA, Sahlin JJ. A simple equation for description of solute release. III. Coupling of diffusion and relaxation. Int J Pharm 1989;57:169-71.




About this article

Title

FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING TABLET USING HIBISCUS ROSA-SINENSIS MUCILAGE

DOI

10.22159/ajpcr.2017.v10i3.16494

Date

01-03-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 3 March 2017 Page: 444-448

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

125 Views | 183 Downloads

Authors & Affiliations

Rohini Sachin More
ASSISTANT PROESSOR DADASAHEB BALPANDE COLLEGE OF PHARMACY, NAGPUR
India

Kharwade Rs

Mahajan Un


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