DESIGN AND INVITRO CHARACTERIZATION OF METFORMIN LOADED RESEALED ERYTHROCYTES


Vidya Viswanad, Aiswarya S, Parvathy S, Aneesh Tp

Abstract


Objective: Metformin is an oral antidiabetic drug in the biguanide class. It is the first-line drug of choice for the treatment of type 2 diabetes. The
objective of this study was to retard the release of metformin using carrier erythrocyte for getting a parenteral slow release depot formulation.

Methods: The study retards the release of metformin by encapsulating in carrier erythrocyte. Endocytosis is the method used for the encapsulation
of the drug metformin.

Results: The optimized formulation shows 98.34% of drug release within 12 days. From the in vitro release data, zero order kinetic graph shows the
best fit graph. % cell recovered was found to be 73-78% and it suggests that the loading technique was less destructive.

Conclusion: The optimized formulation is a perfect carrier for the parenteral slow release depot of metformin.

Keywords: Resealed erythrocytes, Cross-linking, Cell recovery, Endocytosis, Slow release depot formulation.


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About this article

Title

DESIGN AND INVITRO CHARACTERIZATION OF METFORMIN LOADED RESEALED ERYTHROCYTES

DOI

10.22159/ajpcr.2017.v10i4.16636

Date

01-04-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 4 April 2017 Page: 231-238

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

27 Views | 41 Downloads

Authors & Affiliations

Vidya Viswanad

Aiswarya S

Parvathy S

Aneesh Tp

 

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