• Aiswarya S
  • Parvathy S
  • Aneesh Tp
  • Vidya Viswanad


Objective: Metformin is an oral antidiabetic drug in the biguanide class. It is the first-line drug of choice for the treatment of type 2 diabetes. The
objective of this study was to retard the release of metformin using carrier erythrocyte for getting a parenteral slow release depot formulation.

Methods: The study retards the release of metformin by encapsulating in carrier erythrocyte. Endocytosis is the method used for the encapsulation
of the drug metformin.

Results: The optimized formulation shows 98.34% of drug release within 12 days. From the in vitro release data, zero order kinetic graph shows the
best fit graph. % cell recovered was found to be 73-78% and it suggests that the loading technique was less destructive.

Conclusion: The optimized formulation is a perfect carrier for the parenteral slow release depot of metformin.

Keywords: Resealed erythrocytes, Cross-linking, Cell recovery, Endocytosis, Slow release depot formulation.


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How to Cite
S, A., P. S, A. Tp, and V. Viswanad. “DESIGN AND INVITRO CHARACTERIZATION OF METFORMIN LOADED RESEALED ERYTHROCYTES”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 4, Apr. 2017, pp. 231-8, doi:10.22159/ajpcr.2017.v10i4.16636.
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