PREPARATION AND ANALYSIS OF THE NMR SPECTRA OF THE PHARMACEUTICAL SUBSTANCE«OOSE-11,12,13»


K Berkenov, Datkhayev Um

Abstract


Objective: The main issue of this work is obtained, to researching of supramolecular complexes of 20-hydroxyecdysone (20 E) with γ-cyclodextrins (CD).

Methods: The foundation of substance phytoecdysteroid 20 E was isolated from an ethanol extract plant Otites orae-syvaschicae Klok A method of the development of pharmaceutical substances was used during complexed organic relationship in the way of intense mechanical 20 E with α-, β- or γ-СD. The complexation of 20 E with α-, β-, and γ-СD was studied by nuclear magnetic resonance (NMR) method of spectr

Results: In the study of the integrated intensities molecules signals steroid guest and host CD complex stoichiometric ratio 1:1 was prformation of clathrates was established after A and B nuclei ecdysterone had been arranged in the internal cavity of CD.

Сonclusion: Supramolecular complexes of 20 E with α-, β-, and γ-СD were received during made works. The objects of research were analdescribed with the help of NMR spectroscopy. The developed technology will be the main device for operating and identification of pharmaceutical
substance OOSE-11, -12, and -13.

Keywords: Substance Otites orae-syvaschicae Klok-11, -12, -13, 20-hydroxyecdysone, α-, β-, γ-cyclodextrins inclusion complex nuclear resonance spectroscopy.


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About this article

Title

PREPARATION AND ANALYSIS OF THE NMR SPECTRA OF THE PHARMACEUTICAL SUBSTANCE«OOSE-11,12,13»

DOI

10.22159/ajpcr.2017.v10i4.16729

Date

01-04-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 4 April 2017 Page: 292-296

Print ISSN

0974-2441

Online ISSN

2455-3891

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50 Views | 74 Downloads

Authors & Affiliations

K Berkenov

Datkhayev Um


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