• DESHPANDE AH Gurunanak College of Pharmacy, Nari, Nagpur


Objective: The objective of this study is to formulate a tablet that fits in the size range of mini-tablets using wax matrix forming substances, allowsvariation of drug dose and study of drug release kinetics of the dosage form.

Methods: The blends of drug with glyceryl monostearate, purified rice bran wax and carnauba wax that renders the waxes food grade, were preparedand evaluated for precompression characteristics. The blends were compressed into mini-tablets having desirable physical characteristics andwere subjected to tests such as weight variation and friability. The tablets were subjected to drug dissolution test and the release parameters weremathematically treated for order and mechanism of drug release.

Results: The tablets complied with the pharmacopoeial standards of physical characteristics. The release was satisfactorily sustained (up to 10 hrs)by carnauba wax and rice bran wax, but not by glyceryl monostearate (only up to 4 hrs). The release followed a zero order with super Case II transportbeing the major mechanism of drug release.Conclusion: Wax matrix formers were satisfactorily used for sustained drug release mini-tablets. The tablets had good physical characteristics withmajor mechanism of drug release being super Case II transport.

Keywords: Wax matrix, Sustained release, Mini-tablets, Montelukast sodium.

Author Biography

DESHPANDE AH, Gurunanak College of Pharmacy, Nari, Nagpur

Asst. Prof.

Pharmaceutics Deptt.

Gurunanak College of Pharmacy


1. Rosiaux Y, Vincent J, Sophie H, Delphine M. Solid lipid excipients — Matrix agents for sustained drug delivery. J Control Release 2015; 88: 18–30.
2. Sujja-areevath, Munday J, Cox PJ, Khan KA. Release characteristics of declofenac sodium from encapsulated natural gum mini-matrix formulations. Int J Pharm 2005; 139:53-62.
3. Thomsom Physician’s Desk Reference, 62nd ed,: Thomson Healthcare Inc. 2008.p.1926
4. Alderborn, G. 2002.. In: Aulton, M.E. (Ed).Pharmaceutics, the Science of Dosage Form Design. 2nd ed. Harcourt Publishers Limited:London.p.397-440.
5. Compritol 888 ATO product literature
6. Shaik R V, Yi-Hsu J Thengumpillil N B K, Yaw-Terng C. A Process for the Preparation of Food-Grade Rice Bran Wax and the Determination of its components. J Am Oil Chem Soc 2005; 82:57-64
7. Patil BS, Kulkarni U, Bhavik P, Soodam SR, Korwar PG. Formulation and evaluation of mouth dissolving tablets of nimesulide by new coprocessed technique J Pharm Chem Biol Sci 2010; 4Suppl1:587- 592.
8. Lachman L, Liberman H, Kanig J, The theory and practice of industrial pharmacy”, Varghese Publishing House, Mumbai, 3rd ed, 1987.p. 297
9. Daharwal S, Jangde R, Saraf S, Saraf S. Taste masking method for bitter drug and tasteless dispersible tablet: an overview. Famvita.Net Journal 2008; 4:1‐3.
10. Morita Y, Tsushima Y, Yasui M, Termoz R, Ajioka J, Takayama K. Evaluation of the disintegration time of rapidly disintegrating tablets via a novel method utilizing a CCD camera. Chem. Pharm. Bull 2002; 50Suppl 9:1181 ‐ 1186.
11. United States Pharmacopoeia USP25 NF20. The Official Compendia of Standards. First annual Asian edn., Rockville, MD:United States Pharmacopoeial Convention Inc. 2002.p.1326
12. Arora P , Sethi V, Orodispersible Tablets: A Comprehensive Review. Int J Res Dev Pharm L Sci; 2013. 2Suppl 2:270-284
13. J. O. Onyechi1 and S. E. Okafo, Evaluation of carnauba wax in sustained release Diclofenac sodium tablet formulation. J chem pharm res 2016; 8 Suppl3 :714-721.
14. Higuchi T., Rate of release of medicaments from ointment bases containing drugs in suspension. J. Pharm Sci 1961; 50: 874-875.
15. Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA. Mechanisms of solute release from porous hydrophilic polymers. Int J Pharm 1983; 15: 25–35.
16. Peppas NA. Analysis of Fickian and non-Fickian drug release from polymers. Pharm. Acta. Helv. 1985; 60: 110–111.
17. Peppas NA, Sahlin JJ. A simple equation for the description of solute release. III Coupling of diffusion and relaxation. Int. J. Pharm. 1989; 57: 169–172.
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How to Cite
AH, D., and W. D. “DESIGN AND EVALUATION OF FOOD GRADE WAX MATRIX SUSTAINED RELEASE MINI-TABLETS OF MONTELUKAST SODIUM”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 4, Apr. 2017, pp. 317-21, doi:10.22159/ajpcr.2017.v10i4.16788.
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