SORAFENIB INDUCED ACNEIFORM ERUPTIONS: A CASE REPORT

  • Balaji Ommurugan Postgraduate, Department of pharmacology, KMC Manipal, manipal university
  • Amita Priya D Postgraduate, Department of pharmacology, KMC Manipal, manipal university
  • Navin Patil Assistant Professor, Department of pharmacology, KMC Manipal, manipal university

Abstract

ABSTRACT

Sorafenib an oral tyrosine kinase inhibitor is used in the treatment of hepatocellular carcinoma, renal cell carcinoma and thyroid cancer. Sorafenib acts by inhibiting various kinases like tyrosine kinase, RET tyrosine kinase, endothelial growth factor receptor, vascular endothelial growth factor 2 and 3 inhibits angiogenesis and cell proliferation. Acneiform eruptions are known side effect of EGFR inhibitors with incidence ranging between 20 to 90 percent [3], but acneiform eruptions with Sorafenib is seldom seen. Hence, we report a case of Sorafenib induced acneiform eruptions.

Keywords: Sorafenib, EGFR, acneiform eruptions, adverse drug reactions

References

1. Lee WJ, Lee JL, Chang SE, Lee MW, Kang YK, Choi JH, et al. Cutaneous adverse effects in patients treated with the multitargeted kinase inhibitors sorafenib and sunitinib. Br J Dermatol 2009;161(5):1045-51.
2. Scandurra G, Aiello RA, Alì M, Taibi E, Sanò MV, Todaro FM, et al. Appropriate management of cutaneous adverse events maximizes compliance with sorafenib treatment: A single-center experience. Future Oncol 2012;8(5):609-15.
3. Ghatak SB, Panchal SJ. Sorafenib in hepatocellular carcinoma: Hype or hope. Int J Pharm Pharm Sci 2011;3 Suppl 4:1-4.
4. Pickert A, Hughes M, Wells M. Chloracne-like drug eruption associated with sorafenib. J Drugs Dermatol 2011;10(11):1331-4.
5. Cohen PR. Sorafenib-associated facial acneiform eruption. Dermatol Ther (Heidelb) 2015;5(1):77-86.
6. Joncas V, Sammour R, Krasny M, Bouffard D, Provost N. A distinctive cutaneous reaction to sorafenib and a multikinase inhibitor. Int J Dermatol 2008;47:767-9.
7. Fleta-Asín B, Vañó-Galván S, Ledo-Rodríguez A, Truchuelo-Díez M, Jaén-Olasolo P. Facial acneiform rash associated with sorafenib. Dermatol Online J 2009;15(4):7.
8. Patil N, Kunder SK, Avinash A, Pathak A, Madhyastha S, Rao K, et al. Phenytoin-Induced acute generalized exanthematous pustulosis. Asian J Pharm Clin Res 2016;9(2):10-1.
9. Patil N, Rao NK, Balaji O, Hande HM, Rao R, Varghese G, et al. Indapamide induced SIADH with hypokalaemia: A case report. Res J Pharm Biol Chem Sci 2016;7(3):2693.
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How to Cite
Ommurugan, B., A. P. D, and N. Patil. “SORAFENIB INDUCED ACNEIFORM ERUPTIONS: A CASE REPORT”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 4, Apr. 2017, pp. 6-7, doi:10.22159/ajpcr.2017.v10i4.16805.
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Case Study(s)

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