DOES HYPERCHOLESTOLEMIA PREDISPOSE TO ROTATOR CUFF PATHOLOGIES?


Surendra Umesh Kamath, Sunil Murthy

Abstract


Background:  Rotator cuff tear are one of most common orthopedic musculoskeletal problem gaining importance due to large health scale expenditure. Causes of rotator cuff tears are multifactorial and unclear.  Previous studies have suggested relation between elevated serum lipid profile and rotator cuff tear in western population. We therefore undertook study in our Indian population to correlate association of hypercholesterolemia with rotator cuff tear.

Objective: To find association of rotator cuff pathology with hypercholesterolemia in Indian patients.

Materials and methods: After obtaining clearance from institutional ethics committee. We prospectively collected fasting lipid samples of population who came to our hospitals with complaints of shoulder pain during our study period. 50 patients had rupture of rotator cuff which was confirmed by ultrasound of involved shoulder. 50 were seen for non-cuff related complaints.  We followed strict inclusion and exclusion criteria.

Results: Total cholesterol, Triglycerides and low density lipoprotein concentration of patients with rotator cuff tendon tear were on higher side than control group. High density lipoprotein trend showed being lower than control group.  21 of 50 (42%) had high cholesterol (total cholesterol greater than 240mg/dl) than compared to 18 of 50 (36%) in control group. however P value=0.539 and showed no statistical significance between groups.

Conclusion: In Indian population there was no correlation between hypercholesterolemia and rotator cuff tear which is statistically significant.

Key words Rotator cuff tear, Hypercholesterolemia, Indian population.

 

 

 


| PDF |

References


Meislin RJ, Sperling JW, Stitik TP. Persistent shoulder pain: Epidemiology, pathophysiology, and diagnosis. Am J Orthop (Belle Mead NJ) 2005;34 12 Suppl:5-9.

Tempelhof S, Rupp S, Seil R. Age-related prevalence of rotator cuff tears in asymptomatic shoulders. J Shoulder Elbow Surg 1999;8(4):296-9.

Nho SJ, Yadav H, Shindle MK, Macgillivray JD. Rotator cuff degeneration etiology and pathogenesis. Am J Sports Med 2008;36(5):987-93.

Abboud JA, Kim JS. The effect of hypercholesterolemia on rotator cuff disease. Clin Orthop Relat Res 2010;468(6):1493-7.

Hashimoto T, Nobuhara K, Hamada T. Pathologic evidence of degeneration as a primary cause of rotator cuff tear. Clin Orthop Relat Res 2003;415:111-20.

Neer CS 2nd. Anterior acromioplasty for the chronic impingement syndrome in the shoulder: A preliminary report. J Bone Joint Surg Am 1972;54(1):41-50.

Wendelboe AM, Hegmann KT, Gren LH, Alder SC, White GL Jr,

Fig. 5: Total cholesterol distribution in study

Fig. 6: p valueLyon JL. Associations between body-mass index and surgery for rotator cuff tendinitis. J Bone Joint Surg Am 2004;86-A(4):743-7.

Dröge W. Oxidative stress and aging. Adv Exp Med Biol 2003;543:191-200.

Yuan J, Murrell GA, Wei AQ, Wang MX. Apoptosis in rotator cuff tendonopathy. J Orthop Res 2002;20(6):1372-9.

Gill TJ, McIrvin E, Kocher MS, Homa K, Mair SD, Hawkins RJ. The relative importance of acromial morphology and age with respect to rotator cuff pathology. J Shoulder Elbow Surg 2002;11(4):327-30.

Mathiak G, Wening JV, Mathiak M, Neville LF, Jungbluth K. Serum cholesterol is elevated in patients with Achilles tendon ruptures. Arch Orthop Trauma Surg 1999;119(5-6):280-4.

Harvie P, Ostlere SJ, Teh J, McNally EG, Clipsham K, Burston BJ, et al. Genetic influences in the aetiology of tears of the rotator cuff. Sibling risk of a full-thickness tear. J Bone Joint Surg Br 2004;86(5):696-700.

Appel LJ, Sacks FM, Carey VJ, Obarzanek E, Swain JF, Miller ER 3rd, et al. Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: Results of the OmniHeart randomized trial. JAMA 2005;294(19):2455-64.

Londhe SS. A major health hazard - Metabolic syndrome. Int J Pharm Pharm Sci 2011;3(3):18.

Nayak BS, Bhaktha G. Inconsistent lipid profiles exhibited among the diabetic Asian Indians of India and Trinidad - A comparative study. Int J Pharm Pharm Sci 2016;8(12):60-3.

Grundy SM, Cleeman JI, Merz CN, Brewer HB Jr, Clark LT, Hunninghake DB, et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 2004;110:227-39.

Itoi E. Rotator cuff tear: Physical examination and conservative treatment. J Orthop Sci 2013;18(2):197-204.

Jain NB, Wilcox R, Katz JN. Clinical examination of the rotator cuff. Natl Inst Health 2013;5:1-26.

Moosikasuwan JB, Miller TT, Burke BJ. Rotator cuff tears: Clinical, radiographic, and US findings. Radiographics 2005;25(6):1591-607.

Naqvi GA, Jadaan M, Harrington P. Accuracy of ultrasonography and magnetic resonance imaging for detection of full thickness rotator cuff tears. Int J Shoulder Surg 2009;3(4):94-7.

Churchill RS, Fehringer EV, Dubinsky TJ, Matsen FA. Rotator cuff ultrasonography: Diagnostic capabilities. J Am Acad Orthop Surg 2004;12(1):6-11.

Bigliani LU, Ticker JB, Flatow EL, Soslowsky LJ, Mow VC. The relationship of acromial architecture to rotator cuff disease. Clin Sports Med 1991;10(4):823-38.

Millar NL, Wei AQ, Molloy TJ, Bonar F, Murrell GA. Heat shock protein and apoptosis in supraspinatus tendinopathy. Clin Orthop Relat Res 2008;466(7):1569-76.

Goutallier D, Postel JM, Bernageau J, Lavau L, Voisin MC. Fatty muscle degeneration in cuff ruptures. Pre-and postoperative evaluation by CT scan. Clin Orthop Relat Res 1994;304:78-83.

Goutallier D, Postel JM, Bernageau J, Lavau L, Voisin MC. Fatty infiltration of disrupted rotator cuff muscles. Rev Rhum Engl Ed 1995;62(6):415-22.

Lee E, Choi JA, Oh JH, Ahn S, Hong SH, Chai JW, et al. Fatty degeneration of the rotator cuff muscles on pre-and postoperative CT arthrography (CTA): Is the Goutallier grading system reliable? Skeletal Radiol 2013;42(9):1259-67.

Klemp P, Halland AM, Majoos FL, Steyn K. Musculoskeletal manifestations in hyperlipidaemia: A controlled study. Ann Rheum Dis 1993;52:44-8.

Crouse JR, Grundy SM, Ahrens EH Jr. Cholesterol distribution in the bulk tissues of man: Variation with age. J Clin Invest 1972;51(5):1292-6.




About this article

Title

DOES HYPERCHOLESTOLEMIA PREDISPOSE TO ROTATOR CUFF PATHOLOGIES?

DOI

10.22159/ajpcr.2017.v10i4.16883

Date

01-04-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 4 April 2017 Page: 373-376

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

36 Views | 58 Downloads

Authors & Affiliations

Surendra Umesh Kamath
Professor and Head of Orthopaedics KMC Mangalore
India

Sunil Murthy
Postgraduate Resident
India


Article Tools


Email this article (Login required)
Email the author (Login required)

Refbacks

  • There are currently no refbacks.