EFFICACY OF COMBINATION SOLID DISPERSION TECHNOLOGY ON DISSOLUTION PERFORMANCE OF NALIDIXIC ACID AND CEFDINIR


Nidhal Khazaal Maraie, Anas Tarik Alhamdany, Ameera Abd Radhi

Abstract


Objective: The aim of this study was to formulate a new developed solid dispersion containing fixed dose combination of nalidixic acid and cefdinir (500:300 mg) to improve dissolution rate of poorly soluble drugs via a new mechanism as well as the conventional mechanism of solid dispersion represented by the presence of hydrophilic carrier.

Methods:Through this objective eight newly developed solid dispersion formulas of fixed dose combination of nalidixic acid and cefdinir (500:300 mg) and (polyethylene glycol (PEG) 6000 and poloxamer 188) in different ratio were prepared, in addition to solid dispersion of each drug alone and simple mixture of individual solid dispersion prepared by means of fusion technique. Moreover, solid dispersions beside pure drugs, simple mixture and physical mixture were characterized by dissolution tests, solubility studies, powder x-ray diffractometry (PXRD), differential scanning calorimetry (DSC), FT-IR spectroscopy (FT-IR) and scanning electron microscopy (SEM).

Results: From in vitro dissolution tests, PXRD, DSC, FT-IR, and SEM; it is indicated the presence of a physical complex between cefdinir and nalidixic acid in their solid dispersion containing combination of fixed dose of both drugs. This will affect the crystallinity of the second drug and their dissolution behavior in addition to the conventional mechanism owing to the presence of hydrophilic carrier (poloxamer 188).

Conclusion: I was concluded that the newly prepared formula of solid dispersion containing fixed dose combination of nalidixic acid and cefdinir will be promising for higher dissolution profile than that from solid dispersion of each drug alone or simple mixture of individual solid dispersion of each drug.

Keywords: Nalidixic acid, Cefdinir, Poloxamer 188, Polyethylene glycol 6000, Combinational solid dispersion, Fusion method.


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References


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About this article

Title

EFFICACY OF COMBINATION SOLID DISPERSION TECHNOLOGY ON DISSOLUTION PERFORMANCE OF NALIDIXIC ACID AND CEFDINIR

DOI

10.22159/ajpcr.2017.v10i4.16913

Date

01-04-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 4 April 2017 Page: 394-401

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

18 Views | 40 Downloads

Authors & Affiliations

Nidhal Khazaal Maraie
Al-Mustansiriyah University/College of pharmacy
Iraq

Anas Tarik Alhamdany
Al-Mustansiriyah University/College of pharmacy
Iraq

Ameera Abd Radhi
Al-Mustansiriyah University/College of pharmacy
Iraq

 

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