A REVIEW ON ALZHIMER’S DISEASE: PATHOLOGY, MOLECULAR CONDITIONS, MANAGEMNT AND CAUSES


Vinayaga Moorthi, Preethi B

Abstract


Alzheimer’s disease (AD) is a neurodegenerative disorder that starts slowly, progressively leads to death and contributes to about 60-70% cases of dementia. AD is characterized with Senile Plaques (SPs) and neurofibrillary tangles (NFTs) and the major symptoms include problems with language, dis-orientation of words, unable to manage self-care, memory loss and behavioural issues which gradually lead to completely lose bodily functions later. The actual cause for the disease is not known till date. Recent research show distinct paths that closely try to reveal various cytoplasmic, genetic, behavioural, environmental and epigenetic causes that may lead to the development of AD. Most likely all studies target the Senile Plaques, protein fragments called beta-amyloid and Neurofibrillary Tangles, twisted fibres of a protein called tau. Since, the exact causative mechanism is not yet clearly understood, ultimately finding a suitable treatment or management for the disease has also become an ominous challenge for researchers.

 


Keywords


Alzheimer’s disease, Pathology, Phosphatase and tensin, Senile plaques, Neurofibrillary tangles

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About this article

Title

A REVIEW ON ALZHIMER’S DISEASE: PATHOLOGY, MOLECULAR CONDITIONS, MANAGEMNT AND CAUSES

Keywords

Alzheimer’s disease, Pathology, Phosphatase and tensin, Senile plaques, Neurofibrillary tangles

DOI

10.22159/ajpcr.2017.v10i5.16942

Date

01-05-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 5 May 2017 Page: 27-30

Print ISSN

0974-2441

Online ISSN

2455-3891

Authors & Affiliations

Vinayaga Moorthi
Assistant Professor Department of Human genetics and Molecular Biology Bharathiar University Coimbatore - 641 046, Tamil Nadu, INDIA
India

Preethi B
Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu, India
India


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