• Ramu B research scholar department of pharmacy,mewar university chittorgarh,rajasthan
  • Shanmunga Pandiyan P department of pharmacy,mewar university chittorgarh,rajasthan


Objective: Floating bioadhesive tablets of hydrochlorothiazide were developed to prolong gastric residence time leading to an increase in drug
bioavailability where here a combination of floating and bioadhesion mechanism is combined.

Methods: Tablets are prepared by direct compression technique using polymers xanthan gum, carbopol 974 P, HPMC K15M, HPMC K100M, magnesium
Stearate USP-NF (Avicel PH 102), microcrystalline cellulose Ph 102, Talc, and sodium bicarbonate.

Results: Tablets were evaluated for their physical characteristics, namely, hardness, thickness, friability and weight variation, drug content, and
floating properties. The best formulation subjected for kinetic treatment, i.e., zero order, first order, peppas, Higuchi, and Hixon-crowel. The R values
are 0.9366, 0.9364, 0.9680, 0.9974, and 0.9283, respectively.

Conclusion: Optimized formulae F4 containing polymers HPMC K4M and CARBOPOL 974 P showed more bioadhesion with a controlled release over
12 hrs. Therefore, formulation F4 identified as a successful formulation for the development of floating bioadhesive tablets.


Keywords: Hydrochlorothiazide, Floating tablets, Gastroretentive drug delivery system.


1. Grant S. Nizatidine. An updated review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in peptic ulcer and other allied diseases. Drugs 1989;37:801-70.
2. Bandameedi R, Pandiyan S. Formulation and evaluation of floating osmotic tablets of nizatidine. J Appl Pharm 2015;7:209.
3. Whitehead L, Fell JT, Collett JH. Development of a gastroretentive dosage form. Eur J Pharm Sci 1996;4(1):182.
4. Hwang SJ, Park H, Park K. Gastric retentive drug-delivery systems. Crit Rev Ther Drug Carrier Syst 1998;15(3):243-84.
5. Ramu B, Manasa MS. Formulation and evaluation of colon specific drug delivery of press coated lansoprazole tablets. Indo Am J Pharm Res 2015:5(4):1523-32.
6. Padmavathy J, Saravanan D, Rajesh D. Formulation and evaluation of ofloxacin floating tablets using HPMC. Int J Pharm Pharm Sci 2011;3(1):170-3.
7. Li YH, Zhu JB. Modulation of combined release behaviours from a novel tablets-in-capsules system. J Control Release 2004;50:111-22.
8. Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA. Mechanism of solute release from porous hydrophilic polymers. Int J Pharm 1983;15:25-35.
9. Lachman L, Libermann HA, Kaning JL. Tablets. The Theory and Practice of Industrial Pharmacy. 3rd ed. Mumbai: Varghese Publication; 1987. p. 318-20.
10. Hadjiioannou TP, Christian GD, Koupparis MA. Quantitative Calculations in Pharmaceutical Practices and Research. New Delhi: NY-VCH Publishers Inc.; 1993. p. 345-8.
11. Bourne DW. Pharmacokinetics. In: Banker GS, Rhodes CT, editors. Modern Pharmaceutical. 4th ed. New York, NY: Marcel Dekker Inc.; 2002. p. 67-92.
12. Dey S, Dutta S, Mazumder B. Formulation and evaluation of floating matrix tablet of atenolol for gastro-retentive drug delivery. Int J Pharm Pharm Sci 2013;4:433-7.
13. Siepmann J, Peppas NA. Modeling of drug release from delivery system based on hydroxypropyl methylcellulose (HPMC). Adv Drug Deliv Rev 2001;48:139-57.
14. Lee JW, Park JH, Robinson JR. Bioadhesive based dosage forms: The next generation. J Pharm Sci 2000;89:850-66.
15. Higuchi T. Mechanism of sustained action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci 1963;52:1145-9.
16. Alexander S, Juergen S, Roland B. Drug delivery to the upper small intestine window using gastroretentive technologies. Curr Opin Pharmacol 2006;6:501-8.
17. Whitehead L, Fell JT, Sharma HL. Floating dosage forms: An in vivo study demonstrating prolonged gastric retention. J Control Release 1998;55:3-12.
18. Hardman JG, Limbird LE, Gilman AG. The Pharmacological Basis of Therapeutics. New York: McGraw Hill; 2001. p. 774.
19. James WA. Expandable Gastric Retention Device. 2004. US Patent
20. Shato H, Miyagawa Y, Okabe T. Dissolution mechanism of diclofenac sodium from wax matrix granules. J Pharm Sci 1997;86:929-34. 21. ???.
22. Hossain MS, Banik S, Islam MS. Formulation design and characterization of kollidon SR based trimetazidine dihydrochloride matrix tablets. India J Pharm Educ Res 2012;46:136-44.
23. Rosa M, Zia H, Rhodes T. Design and testing in vitro of a bioadhesive and floating drug delivery system for oral application. Int J Pharm 1994;105:65-70.
24. Colombo P, Bettini R, Santi P, Ascentiis DA, Peppas NA. Analysis of the swelling and release mechanisms from drug delivery systems with emphasis on drug solubility and water transport. J Control Release 1996;39:231-7.
562 Views | 469 Downloads
How to Cite
B, R., and S. P. P. “FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING BIOADHESIVE TABLETS OF HYDROCHLORTHIAZIDE”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 5, May 2017, pp. 150-5, doi:10.22159/ajpcr.2017.v10i5.17137.
Original Article(s)