DEVELOPMENT OF PARTICULATE MUCOADHESIVE GEL FOR INTRANASAL DELIVERY
Objective: The objective of this research work was to develop mucoadhesive particulates gel of Propranolol HCl for intranasal delivery.
Method: Drug loaded mucoadhesive particulates were prepared by spray drying technique using polymers such as HPMC K100 and Carbopol 934P. Batches were prepared according to 32 factorial designs. Â Â
Result: The mucoadhesive particulates prepared were evaluated for different parameters like drug content, entrapment efficiency, mucoadhesive strength and in vitro drug release. IR, XRD and DSC study revealed that there were no interaction occurs between drug and excipients and confirming reduction in crystallinity. The swelling index and encapsulation efficiency was found to be (0.9266%), (97.44%), angle of repose, Carrâ€™s compressibility index falls in acceptable limits. At the end of 10 hr optimized batch showed 90.23 % drug release and followed zero order release kinetics.
Conclusion: Conclusion from result of the studies such as increase in the concentration of polymers contributed in drug release retardation. Although, prepared formulation of nasal administration can be a value addition in treatment for heart diseases like angina pectoris, myocardial
2. Dhakar R, Sheo D. A review on factors affecting the design of nasal drug delivery system. Int J Drug Deliv 2011;3(2):94-208.
3. Yadav V, Gupta AB, Raj K, Yadav J, Brajesh K. A Mucoadhesive polymers: Means of improving the mucoadhesive properties of drug delivery system. J Chem Pharm Res 2010;2(5):418-32.
4. Ranjna D, Archana C, Pandit V. Mucoadhesive in situ nasal gel - A novel approach. J Adv Drug Deliv 2014;1(6):1-8.
5. Ankita G, Prashant U. Mucoahesive microspheres: A short review. Asian J Pharm Clin Res 2012;5(3):24-7.
6. Yadav A, Jain D. Formulation and evaluation of mucoadhesive microspheres of propranolol hydrochloride for sustained drug delivery. Asian J Pharm Med Sci 2011;1(1):1-8.
7. Kumar A, Balakrishna T, Jash R, Murthy TE, Kumara A, Sudheer B. Formulation and evaluation of mucoadhesive microcapsules of metformin HCL with gum karaya. Int J Pharm Pharm Sci 2011;3(3):150-5.
8. Velmurugan S, Ali MA. Mucoadhesive microspheres - An overview. Int J Drug Dev Res 2013;5(3):229-33.
9. Rajeshwar K, Singh B, Juyal A. Mucoadhesive microspheres of famotidine: Preparation characterization and in-vitro evaluation. Int J Engg Sci Tech 2010;2(6):1575-80.
10. Velmurugan S, Ali MA. Formulation and evaluation of maraviroc mucoadhesive microspheres by ionotropic gelation method. Int J Pharm Pharm Sci 2013;5:294-302.
11. Prasant R, Amitava G, Udaya N, Nayak B. Effect of method of preparation on physical properties and in vitro drug release profile of losartan microspheres - A comparative study. Int J Pharm Pharm Sci 2009;1(1):108-18.
12. Desai S, Vidyasagar G, Shah V, Desa D. Preparation and in vitro characterization of mucoadhesive microspheres of midazolam: Nose to brain administration. Asian J Pharm Clin Res 2011;4(1):100-2.
13. Gangurde HH, Chavan NV, Mundada AS, Derle DV, Tamizharasi S. Biodegradable chitosan-based ambroxol hydrochloride microspheres: Effect of cross-linking agents. J Young Pharm 2011;3(1):9-14.
14. Pachuau L, Sarkar S, Mazumder B. Formulation and evaluation of matrix microspheres for simultaneous delivery of salbutamol sulphate and theophylline. Trop J Pharm Res 2008;7(2):995-1002.
15. Bamba M, Puisieux F. Release mechanism in gel forming sustained release preparation. Int J Pharm 1979;2(5-6):307-15.
16. Gohel MC, Amin AF. Formulation optimization of controlled release diclofenac sodium microspheres using factorial design. J Control Release 1998;51(2-3):115-22.
17. Dasari A, Sellappan V. Formulation and evaluation of nevirapine mucoadhesive microspheres. Int J Pharm Pharm Sci 2015;7(6):342-8.
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