Retrospective analysis of prescriptions in the management of lepra reactions: Results of a single center study from tertiary hospital in Maharashtra

  • Madhuri Kulkarni Associate Professor, Dept of Pharmacology, Govt Medical College, Aurangabad
  • Anant Patil Assistant Professor, Bharati Vidyapeeth Deemed University Dental College & Hospital, Navi Mumbai
  • Siddharth Aathawale Resident, Dept. of Pharmacology, Govt Medical College, Aurangabad

Abstract

Objective: To examine pattern of lepra reaction andmedicines used in the treatment of lepra reactions in a tertiary hospital.

Material methods: In this retrospective study, prescriptions of patients treated for the lepra reactions were reviewed to find out prevalence of type 1 and type 2 reactions and medicines used in the treatment of lepra reactions.

Results:A total of66 patients (male 59.1%; female 40.9%) with mean age of 36.6 (+13.1) years were included in the study. Multibacillary leprosy was present in 93.7% patients.  A total of 39 (60%) patients had type 2 reaction whereas 26 (40%) had type 1 reaction. Mean number of medicines per patients was 7.5. Prednisolone was used in 62 (93.9%) patients with mean duration of 33.32 (+33.2) days whereas chloroquine was used in 52 (78.8%) patients for 36.6 (+27.9) days. Thalidomide was used in 25 (37.9%) patients. Analgesic and anti-inflammatory and anti-acidity drugs were used in 63 (95.4%) patients each whereas paracetamol was given to 41 (62.1%) patients. Antihistamine, antimicrobial agent and vitamins were given to 27 (40.9%), 27 (40.9%) and 35 (53.0%) patients respectively.

Conclusion:Lepra 2 reaction is more common than lepra 1 reaction.  Prednisolone and chloroquine are the two most commonly used medicines in the treatment of lepra reaction. Similarly, thalidomide, older drug has emerged as common treatment for lepra reaction.

Keywords: Lepra reaction, Retrospective analysis, Maharashtra.

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Kulkarni, M., A. Patil, and S. Aathawale. “Retrospective Analysis of Prescriptions in the Management of Lepra Reactions: Results of a Single Center Study from Tertiary Hospital in Maharashtra”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 5, May 2017, pp. 191-3, doi:10.22159/ajpcr.2017.v10i5.17346.
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