• Tamizhazhagan V Department of Zoology, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, India.
  • Pugazhendy K Department of Zoology, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, India.


Pisonia alba is used for the long period in various chronic diseases in traditional medicine use. To desire of this review is to search literature for the pharmacological properties toxicity studies, pharmacology studies and phytochemical exploration of anti-inflammation, antidiabetic studies,antioxidant, etc., and the amassed data may be helpful for the researchers to attention on the significance areas of research yet to be revealed. Widespread information about the plant has been together from various books, journals and ayurvedic classical texts, etc. Researcher and pharmacologist and Ayurveda treatment may be helpful security of the whole plant was settled in the criticism.



Keywords: Pisonia alba, Antioxidant, Ayurvedic, Novel drug, Ethno botanical.


United Nations Environment Programme, USA: World Meteorology Organization.
5. Narayanan Ravisankar, Chandrasekaran Sivaraj, Sooriamuthu Seeni, Jerrine Joseph Nanjian Raaman (2014). Antioxidant activites and phytochemical analysis of methanol extract of leaves of Hypericum hookerianum. Int J Pharm Pharm Sci, Vol 6, Issue 4, 456-460.
6. Agrawal VS, (1986). Economics plants of India. Botanical Survey of India. 161:2–9.
7. Gayathri G.A. Gayathri M (2014).Preliminary qualitative phytochemical screening and in vitro hypoglycemic potential of Acanthus ilicifolius and evolvulus emerginatus Int J Pharm Pharm Sci, Vol 6, Issue 6, 362-365.
8. Bulletin of the World Health Organization (WHO) July 2002, Vo1.80:7.
9. Augustine Amalraj, Anitha Pius (2015). Bioavailability of calcium and its absorption inhibitors in raw and cooked green leafy vegetables commonly consumed in India – An in vitro study J. Food Chemistry 170 :430–436
10. Mandal, V, Mohanand Y, Hemalatha S, (2007). Microwave assisted extraction –an innovative and promising extraction tool for medicinal plant research .Pharmacog.Rev : 7 – 8.
11. Krishnaiah D, Sarbatly R, Bono A. (2007). Phytochemical antioxidants for health and medicine: A move towards nature. Biotechnol Mol Biol Rev; 1(4):97-104.
12. Jagadishchandra, K.S, Rachappaji, S, Gowda, K.R.D. and Tharasaraswathi, K.J. (1999). In vitro propagation of Pisonia alba (L.) Spanogae (Lettuce Tree) Athreatened species. Phytomorphol 49 (1):43-47.
13. Rachel A. Levin, Robert A. Raguso, Lucinda A. Mc Dade (2001). Fragrance chemistry and pollinator affinities in Nyctaginaceae Phytochemistry 429–440.
14. Verne Grant and Karen A. Grant (1983). Hawkmoth pollination of Mirabilis longiflora (Nyctaginaceae) Proc. NatL Acad. Sci. USA Vol. 80, pp. 1298-1299.
15. Rawat AKS, Mehrotra S, Tripathi SC and Shome U (1997). Hepatoprotective activity of Boerhaavia diffusa L. roots a popular Indian ethnomedicine., Journal of Ethnopharmacology, 56, 61-66 .
16. Chude MA, Orisakwe OE, Afonne OJ, Gamaniel KS, Vongtau PH and Obi E (2001). Hypoglycaemic effect of the aqueous extract of Boerhavia diffusa leaves, Indian Journal of Pharmacology, 33: 215- 216.
17. Adama Hilou, Jeanne Millogo-Rasolodimby and Odile Germaine Nacoulma (2013). Betacyanins are the most relevant antioxidant molecules of Amaranthus spinosus and Boerhavia erecta Journal of Medicinal Plants Research Vol. 7(11), pp. 645-652.
18. Salman Khan M., Irfan A. Ansari, Saheem Ahmad, Firoz Akhter, Arshya Hashim, A. K. Srivastava (2013). Chemotherapeutic potential of Boerhaavia diffusa Linn: A review Journal of Applied Pharmaceutical Science Vol. 3 (01), pp. 133-139.
19. Rajeswari , P And S. Krishnakumari (2010). Boerhaavia erecta-A potential source for phytochemicals and antioxidants J. Pharm. Sci. & Res. Vol.2 (11), 728-733.
20. Umamaheswari A., R. Shreevidya and Aparna Nuni(2008). In vitro Antibacterial Activity of Bougainvillea spectabilis Leaves Extracts Advances in Biological Research 2 (1-2): 01-05.
21. Narayanan CR, Joshi DD and Mujumdar AM (1984). Hypoglycemic action of Bougainvillea spectabilis leaves, Curr. Sci, 53: 579-581.
22. Manali Mangesh Mahajan, Sujata Dudhgaonkar, Swapnil Narayan Deshmukh (2015). Anti-diabetic and hypolipidemic effects of the aqueous leaf extract of Bougainvillea species International Journal of Basic & Clinical Pharmacology Vol :4 Issue 3 pp596.
23. Charushila N. Hajare, Farida R. Inamdar, Reshma V. Patil, Chidanand S. Shete, Suryakant S. Wadkar, Kumar S. Patil, Jai S. Ghosh (2015).Antibacterial Activity of the Leaves of Bougainvillea spectabilis against E. coli NCIM 2832 and M. aureus NCIM 5021 Int. J. Pharm. Sci. Rev. Res., 34(1), Article No. 31, Pages: 194-196.
24. Sandeep Dhankhar, Mamta Sharma, Sonam Ruhil, Meenakshi Balhara, Manish Kumar, Anil k Chhillar (2013). Evaluation of antimicrobial and antioxidant activities of bougainvillea spectabilis Int J Pharm Pharm Sci, Vol 5, Suppl 3, 178-182.
25. Rith Watthanachaiyingcharoen, Parkpimo Utthasin, Tulaya Potaros and Prapan Suppakpatana (2010). Proteins from Mirabilis jalapa possess anticancer activity via an apoptotic pathway j health res, 24(4): 161-165.
26. Naveed Ullah, Mir Azam Khan, Haider Ali, Nouman Altaf, Shakoor Ahmad, Ghayour Ahmed and Minhaj ud Din (2011) . Importance of white flowered Mirabilis jalapa with respect to its phytochemical and antimicrobial screening African Journal of Pharmacy and Pharmacology Vol. 5(24), pp. 2694-2697.
27. Sumithra P, Varalakshmi S, Devasena K (2014). Phytochemical Analysis and Antibacterial Activity of Mirabilis jalapa Flower against Gastro Intestinal Pathogens Volume 3 Issue 12.
28. Savita G. Aggarwal and Sanjay Goyal (2013). Nyctanthes arbor-tristis Against Pathogenic Bacteria JPP; 2 (3): 124-127
29. Stemmerik JF, Flora Malesianae Precursores, Notes on Pisonia L. in the Old World, Blumea, (1964). Int. J. Pharm. Sci. Rev. Res 12, 275-284.
30. Shyamali Singha, Meenakshi Bawari, Manabendra Dutta Choudhury (2014). Hepatoprotective and Antipyretic Effect of Bark of Nyctanthes arbortristis Linn. Int J Pharm Pharm Sci, Vol 6, Suppl 2, 110-114
31. Komdeur, J and Kats, R. K, (1999). Predation risk affects trade-off between nest guarding and foraging in Seychelles warblers. Behavioral Ecology, 10(6), 648-658.
32. Dhanasekar, S and S. Sorimuthu, (2005). Beneficial effects of Momordica charantia seeds in the treatment of STZ - induced diabetes in experimental rats. Biol Pharm Bull, 28, 978-983.
33. Shubashini, K.S., Poongothai, G and Lalitha, P, (2011). Allantoin from the leaves of Pisonia grandis R. Br. Int. J. Pharm. Life Sci, 2, 815-817.
34. Saritha B, Karpagam S (2015).Phytochemical Content of Leaf and In Vitro Established Callus Culture of Pisonia alba Span International Journal of Science and Research (IJSR) Volume 4 Issue 1.
35. Sravanthi, G.V. Manasa S.L., Sravan Kumar B., Asha S. and Bharath Kumar R.
(2013).In-vitro experimental studies of selected biopesticides& their effect on selected plant pathogens Int. J. of Pharm. & Life Sci. (IJPLS), Vol. 4, Issue 9: 2931-2944.
36. Kiritikar K and Basu L (1935). Indian Medicinal Plants, Allahabad, India, Vol. III, 2nd ed., pp: 1817-1818.
37. Radha, R., S. Arokiyaraj, P. Agastian, K. Balaraju, R. Mohan Kumar and P. Balu, (2008). Phytochemical analysis and anti-inflammatory activity of Pisonia grandis R. Br. J. Biomed. Pharmacol., 1: 21-27.
38. Sunil Christudas, LathaGopalakrishnan, PalanisamyMohanraj, Kalichelvan Kaliyamoorthy, Paul Agastian (2009). α-Glucosidase inhibitory and antidiabetic activities of ethanolic extract of Pisonia alba Span. Leaves IJIB,Vol. 6, No. 1, 41.
39. Kim, M.K., Y.S. Jang, Y.J. Ahn, D.K. Lee and H.S. Lee, (2002). Larvicidal activity of Australian and mexican plant extracts against Aedes aegypti and Culex pipiens pallens (Diptera: Culicidae). J. Asia-Pac. Entomol., 5: 227-23.
40. Pari L, Uma MJ. (1999). Hypoglycaemic effect of Musa sapientum L. in alloxan-induced diabetic rats. J. Ethnopharmacol 68:321-325.
41. Govindappa M (2015) .A Review on Role of Plant(s) Extracts and its Phytochemicals for the Management of Diabetes. J Diabetes Metab 6:565. doi:10.4172/2155-6156.1000565.
42. Pugazhendy K., Revathi., C. Jayanthi., V. Sakthidasan and V. Tamizhazhagan (2015). Therapeutic efficacy of pisoniaalbaagainst atrazine toxicity on biochemical parameters in the liver tissue of albino wister rat rattus norvegicus Volume – 1; Issue - 5; Page: 358 – 364.
43. Revathi, A., K. Pugazhendy and C. Jayanthi (2016). Ameliorative Properties Of Pisonia Alba Against Atrazine Toxicity On Thyroid Hormones Activity In The Albino Wister Rat Rattus Norvegicus 433-439.
44. Saritha,B., Karpagam and Sumathi studies on antioxidant activity, phenol and flavonoid content of pisonia alba Span (2014). Asian J Pharm Clin Res, Vol 7, Issue 3,106-109.
45. Vidyalakshni A and Divya CV. (2013). New report of Colletotrichum gloeosporioides causing anthracnose of Pisonia alba in India. Arch Phytopathol Pl Prot 46: 201 – 204.
46. Prabu, D., M. Nappinnai, K. Ponnudurai and K. Prabu, (2008). Evaluation of wound healing potential of Pisonia grandis R.Br: A predinical study in Wister rats. Int. J. Lower Extrem. Wounds, 7: 21-27.
47. Pugazhendy K, Revathi A, Prabakaran S, Murugan K and Jiang-Shiou Hwang (2015). Convalesce consequence of Pisonia alba and Cardiospermum halicacabum aligned with the atrazine inebriated on antioxidant enzymes and histological changes in liver tissue of Rattus norvegicus IJALS, Volume (8) Issue (1).
48. Kalaichellvan V(2009). Effect of Ethanlic extract of Pisonia Alba Span. Leaves on Blood Glucose levls and Histological Changs in Tissues of Alloxan-Induced Diabetic rats. Int. Journal of Applied Research in Natural Products, 2 (2), 4-11.
49. Christudas S, Gopalakrishnan L, Mohanraj P, Kaliyamoorthy K, Agastian P (2009) a-Glucosidase inhibitory and antidiabetic activities of ethanolic extract of Pisonia alba Span. leaves. International Journal of Integrative Biology 6:41-45.
50. Subhasree B, Baskar R, Keerthana RL, Susan RL, Rajasekaran P (2009).Evaluation of antioxidant potential in selected green leafy vegetables. Food Chem. 115: 1213-1220.
51. Prabakaran S, Pugazhendy K, Revathi and Jayanthi 2014. Alleviate potential of Pisonia alba and Cardiospermum halicacabum on the Antioxidant Enzymes such as glutathione-S-transferese and reduced Glutathione (GSH) Activity by the Herbicide Atrazine induced Hepatic tissue of freshwater fish Labeo rohita. Int. J. Modn. Res. Revs. Volume 2, Issue 11, pp 492-496.
52. Jagadeesan P, Arun Prasad D, Pandikumar P, Ignacimuthu S (2011). Antioxidant and free radical scavenging activates of common wild greens from Thiruvalluvar District of Tamilnadu, India. Indian Journal of Natural Production and Resource Vol 2(2), pp 156-163.
665 Views | 628 Downloads
How to Cite
V, T., and Pugazhendy K. “ETHNOBOTANICAL AND PHYTOPHARMACOLOGICAL REVIEW OF PISONIA ALBA SPAN”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 5, May 2017, pp. 69-71, doi:10.22159/ajpcr.2017.v10i5.17356.
Review Article(s)