TOPICAL ANALGESIC ACTIVITY OF ESSENTIAL OIL EXTRACTED FROM SPHARENTHUS INDICUS (ASTERACEAE)

  • Dipti Kanta Padhan Department of Pharmacognosy, the Pharmaceutical College, Bijenagar, Odisha, India.
  • Patel Sriballav Department of Pharmacognosy, the Pharmaceutical College, Bijenagar, Odisha, India.
  • Mohanty Arnabaditya

Abstract

Objective: To evaluate the topical analgesic effects of essential oil extracted from Spharenthus indicus (Asteraceae).

Methods: The essential oil was extracted from fresh flower of Spharenthus indicus. Topical ointment containing essential oil was investigated for analgesic activity in rat using hot plate method. Diclofenac sodium gel was taken as standard drug.

Result: The analgesic activity of topical preparation was observed in the early phase. The analgesic activity of topical preparation showed significant activity comparative to standard drug diclofenac sodium.

Conclusion: Hence the study validates the traditional use of Spharenthus indicus to relive pain.

 

Keywords: Analgesic activity, Sphaeranthus indicus, Essential oil, Topical ointment.

Author Biography

Dipti Kanta Padhan, Department of Pharmacognosy, the Pharmaceutical College, Bijenagar, Odisha, India.
Associate Professor Department of Pharmacognosy

References

Reference
1. Merskey H, “Pain terms: a list with definitions and notes on usage. Recommended by the lASP Subcommittee on Taxonomy,” Pain 1979; 6:249–252.
2. Olateju SO, Adenekan AT, Olufolabi AJ, Owojuyigbe AM, Adetoye AO, Ajenifuja KO et al., Pentazocine Versus Pentazocine with Rectal Diclofenac for Postoperative Pain Relief after Cesarean Section- A Double Blind Randomized Placebo Controlled Trial in a Low Resource Area. Middle East J Anaesthesiol 2016; 23(4):443-8.
3. Hewitt DJ, Hargreaves RJ, Curtis SP,Michelson D, “Challenges in analgesic drug development,” Clinical Pharmacology &Therapeutics 2009; 86(4):447–450.
4. Hanson GR, Venturelli PJ, Fleckenstein AE, Drugs and Society, Jones and Bartlett, Boston,Mass, USA, 10th edition, 2009.
5. Ekor M. The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol 2014; 4(177):1-10
6. Makhija IK, Richard L, Kirti SP, Saleemullah K, Jessy M, Annie S. Shaeranthus indicus: A Review of its Chemical, Pharmacological and Ethnomedicinal Properties. Int J Pharmacol 2011; 7(2): 171-179.
7. Nayak S, Behera SK, Misra MK. Ethno-medico-botanical survey of Kalahandi district of Orissa, Indian J Tradit Knowle 2004; 3:72
8. Kirtikar KR, Basu BD. Indian medicinal plant, II. Allahabad: Lalit Mohan Basu Publication; 1935.p. 1347.
9. Sen, S.K., Pradhan, N.B., Behera, L.M., Ethnomedicinal plants used against dysurea at Bargarh district in Orissa. Ad Plant Sci., 2001, 14: 459-462.
10. Chopra, R.N., Chopra, I.C., Handa, K.L., Kapur, L.D., Chopras Indigenous Drug of India,Calcutta, India: U.N. Dhur and Sons, 1958, 601.
11. Samuel, J.K., Andrews, B., Traditional medicinal plant wealth of Pachalur and hamlets Dindigul district, Tamil Nadu, Indian J. Traditional Knowledge, 2010, 9(2), 264-270.
12. Wabale, A.S., Petkar, A.S., Ethnomedicinal plants used against jaundice by the tribals of Akole taluka (MS), J. Phytol. Res., 2005, 18(2), 259-26.
13. Jeeva, S., Kiruba, S., Mishra, B.P., Venugopal, N., Dhas, S.S.M., Regini, G.S., Kingston, C., Kavitha, A., Sukumarans, S., Raj, A.D.S., Laloo, R.C., Weeds of Kanyakumari district and their value in rural life, Indian J. Traditional Knowledge, 2006, 5(4), 501-509.
14. Nanda, B.K., Jena, J., Rath, B., Behera, B.R., Anagesic and Antipyretic activity of whole parts of Sphaeranthus indicus Linn. J Chem and Pharm Research., 2009, 1(1): 207-212.
15. Malairajan, P., Babu, G.V., Saral, A., Mahesh, S., Gitanjali., Analgesic Activity of Sphaeranthus indicus Linn. Int J Drug Dev and Res., 2012, 4: 130-132.
16. Meher, B.R., Jena, J., Rath, B.G., Evaluation of analgesic activity of ethanolic extract of Sphaeranthus indicus. Scholars Research Library, Der Pharmacia Lettre., 2011, 3(3): 357-360.
17. Dennis, S. G. & R. Melzack: Comparison of phasic and tonic pain in animals. Adv. Pain Res. Ther 1979, 3, 747-760.
18. Chapman, C. R., K. L. Casey, R. Dubner, K. M. Foley, R. H. Gracely & A. E. Reading: Pain measurement: an overview. Pain 1985, 22, 1-31.
19. Viljoen AM, Subramoney S, van Vuuren SF,Bas KHC, Demirci B. The composition, geographical variation and antimicrobial activity of Lippia javanica (Verbenaceae) leaf essential oils. Journal of Ethnopharmacology 2005; 96: 271–277.
20. Chhetri HP, Yogol NS, Sherchan J, Anupa KC, Mansoor S, Thapa P. Formulation and Evaluation of Antimicrobial Herbal Ointment. Kathmandu University J Sc, Engg and Tech 2010; 6 (1): 102-107.
21. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983; 16(2):109-10.
22. Abdallah FI, Dawaba HM, Mansour A, Samy AM. Evaluation of the Anti-inflammatory and Analgesic Effects of Piroxicamloaded Microemulsion in Topical Formulations. Int J Pharm Pharm Sci 2011 3(2): 66-70.
23. Galani VJ, Patel BG, Rana DG. Sphaeranthus indicus Linn.: A phytopharmacological review. Int J Ayurveda Res 2010; 1(14): 247-53.
24. Sousa de DP. Analgesic-like Activity of Essential Oils Constituents. Molecules 2011; 16:2233-2252.
25. Sarmento-Neto JF, Nascimento LG, Felipe CFB, Sousa de DP. Analgesic Potential of Essential Oils. Molecules 2016; 21(20):1-29.
26. Svoboda KP, Deans SG. Biological activities of essential oils from selected aromatic plants. Acta Horticulture 1995; 390(1): 203-209.
27. Cabo J, Crespo ME, Jimenez J, Zarzuelo A. The spasmolytic activity of various aromatic plants from the province of Granada. I. The activity of the major components of their essential oils.Plant Med Phytother 1986; 20: 213–218.
28. Santos FA, Rao VSN. Antiinflammatory and antinociceptive effect of 1, 8-cineole, a terpenoid oxide present in many plant essential oil. Phytother Res 2000; 14:240–244.
29. Ozbek H, Tas A, Ozgokce F, Selcuk N, Alp S, Karagoz S. Evaluation of median lethal dose and analgesic activity of Foeniculum vulgare Miller essential oil. Int J Pharmacol 2006; 2:181–183.
30. Lee SK, Hong CH, Huh SK, Kirn SS, Oh OJ, Min HY, Park KK, Chung WY, Wang JK. Suppressive effect of natural sesquiterpenoids on inducible cycloxygenase (COX-2) and nitric oxide synthase (iNOS) activity in mouse macrophase cells. J Environ Path Toxicol Oncol 2002; 21: 141–148.
Statistics
281 Views | 462 Downloads
Citatons
How to Cite
Padhan, D. K., P. Sriballav, and M. Arnabaditya. “TOPICAL ANALGESIC ACTIVITY OF ESSENTIAL OIL EXTRACTED FROM SPHARENTHUS INDICUS (ASTERACEAE)”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 5, May 2017, pp. 275-7, doi:10.22159/ajpcr.2017.v10i5.17594.
Section
Original Article(s)