ORAL CAVITY SQUAMOUS CELL CARCINOMA IN A CASE OF IFAP SYNDROME WITH CHRONIC MYELOID LEUKEMIA ON LONG TERM HYDROXYUREA: A RARE PRESENTATION
We report a case ofÂ a patientÂ in his earlyÂ 30sâ€™ who presented with an ulcero-proliferative growth over the left buccal mucosa , he was also on treatment for CML in blast crisis on Hydroxyurea and a known case of Ichthyosis Follicularis, Alopecia, and Photophobia (IFAP) syndrome. Though a working diagnosis of chloroma / Hydroxyurea induced erosive Lichen planusÂ was suspected, the histopathological examination of the lesion was suggestive of Squamous cell Carcinoma. He was subsequently planned for palliative radiotherapy .
2. Keyvani K, Paulus W, Traupe H, Kiesewetter F, Cursiefen C, Huk W, et al. Ichthyosis follicularis, alopecia, and photophobia (IFAP)
syndrome: Clinical and neuropathological observations in a 33-yearold man. Am J Med Genet 1998;78(4):371-7.
3. Boente MC, Bonet HB, Coronel AM, Asial RA. Atrichia, ichthyosis follicular hyperkeratosis, chronic candidiasis, keratitis, seizures,
mental retardation and inguinal hernia: A severe manifestation of IFAP syndrome? Eur J Dermatol 2000;10:98-102.
4. Darji AA, Bharadia PD. Chronic myelogenous leukemia: A review and update of current and future therapy. Int J Pharm Pharm Sci 2016;8:35-46. Available from: http://www.innovareacademics.in/ journals/index.php/ijpps/article/view/12124.
5. Ting CY, Shamsuddin AF. Optimized RNA extraction for detection of BCR-ABL transcripts in chronic myeloid leukemia patients during treatment. Int J Pharm Pharm Sci 2014;6(1):415-8.
6. De Benedittis M, Petruzzi M, Giardina C, Lo Muzio L, Favia G, Serpico R. Oral squamous cell carcinoma during long-term treatment with hydroxyurea. Clin Exp Dermatol 2004;29(6):605-7.
7. Budrukkar A, Muttagi S, Shahid T, Chatturvedi P, Banavali S, Laskar SG, et al. Second primary head and neck squamous cell cancers
with aggressive behavior in patients with chronic myeloid leukaemia. Br J Oral Maxillofac Surg 2012;50(6):504-7.
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