ORAL CAVITY SQUAMOUS CELL CARCINOMA IN A CASE OF IFAP SYNDROME WITH CHRONIC MYELOID LEUKEMIA ON LONG TERM HYDROXYUREA: A RARE PRESENTATION

  • Uday Kumar P MNJ INSTITUTE OF ONCOLOGY, REGIONAL CANCER CENTRE , HYDERABAD, TELANGANA 500004
  • Anshul Singh MANIPAL UNIVERSITY
  • Anusha Reddy s MANIPAL UNIVERSITY
  • VIDYASGAR MS MANIPAL UNIVERSITY
  • Prahlad Hy MANIPAL UNIVERSITY

Abstract

We report a case of  a patient  in his early  30s’ who presented with an ulcero-proliferative growth over the left buccal mucosa , he was also on treatment for CML in blast crisis on Hydroxyurea and a known case of Ichthyosis Follicularis, Alopecia, and Photophobia (IFAP) syndrome. Though a working diagnosis of chloroma / Hydroxyurea induced erosive Lichen planus  was suspected, the histopathological examination of the lesion was suggestive of Squamous cell Carcinoma. He was subsequently planned for palliative radiotherapy .

 

Keywords: Hydroxyurea, Ichthyosis follicularis, alopecia, and photophobia, Myeloid leukemia.

Author Biographies

Uday Kumar P, MNJ INSTITUTE OF ONCOLOGY, REGIONAL CANCER CENTRE , HYDERABAD, TELANGANA 500004

DEPARTMENT OF RADIOTHERAPY
SENIOR RESIDENT

Anshul Singh, MANIPAL UNIVERSITY
DEPARTMENT OF RADIOTHERAPY AND ONCOLOGY
ASSISTANT PROFESSOR
Anusha Reddy s, MANIPAL UNIVERSITY

DEPARTMENT OF RADIOTHERAPY
SENIOR RESIDENT

VIDYASGAR MS, MANIPAL UNIVERSITY

DEPARTMENT OF RADIOTHERAPY
PROFESSOR

Prahlad Hy, MANIPAL UNIVERSITY

DEPARTMENT OF RADIOTHERAPY
ASSISTANT PROFESSOR

References

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P, U. K., A. Singh, A. Reddy s, VIDYASGAR MS, and Prahlad Hy. “ORAL CAVITY SQUAMOUS CELL CARCINOMA IN A CASE OF IFAP SYNDROME WITH CHRONIC MYELOID LEUKEMIA ON LONG TERM HYDROXYUREA: A RARE PRESENTATION”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 5, May 2017, pp. 1-3, doi:10.22159/ajpcr.2017.v10i5.17665.
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Case Study(s)