VARIOUS BIOLOGICAL ACTIVITIES OF COUMARIN AND OXADIAZOLE DERIVATIVES


Sunny Jalhan, Sukhdev Singh, Rupinder Saini, Navdeep Singh Sethi, Upendra K Jain

Abstract


In this review article data is collected regarding the various derivatives of coumarin and oxadiazole as both these have wide range of biological activities and they can be further modified to synthesize more effective and potent drugs. Coumarin class of organic compounds consists of 1,2-benzopyrone ring system as a basic parent scaffold. These benzopyrones are subdivided into alpha-benzopyrones and gamma benzopyrones; with coumarin class of compounds belonging to alpha-benzopyrones. Since the last few years, coumarins were synthesized in many of their derivative forms. Their pharmacological, therapeutic and biochemical properties depend upon their pattern of substitution. Coumarins exhibit a wide range of pharmacological activities, which includes anti-diabetic, anti-viral, anti-microbial, anticancer, anti-oxidant, anti-parasitic, anti-helminthic, anti-proliferative, anti-convulsant, anti-inflammatory and antihypertensive activities. 1,3,4-Oxadiazole is a heterocyclic compound containing an oxygen atom and two nitrogen atoms in a five-membered ring. It is derived from furan by substitution of two methylene groups (=CH) with two pyridine type nitrogens (-N=). There are three known isomers: 1,2,4-oxadiazole, 1,2,3-oxadiazole and 1,2,5- oxadiazole. Oxadiazole moiety shows antimicrobial, anticancer and anti-inflammatory activity and suitably substituted 1,3,4-oxadiazole having biological activities like antimicrobial, anticancer and other biological activities.


Keywords


Coumarin derivatives, Oxadiazole derivatives, Biological activities, 1,3,4-oxadiazole, Hybrids.

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About this article

Title

VARIOUS BIOLOGICAL ACTIVITIES OF COUMARIN AND OXADIAZOLE DERIVATIVES

Keywords

Coumarin derivatives, Oxadiazole derivatives, Biological activities, 1,3,4-oxadiazole, Hybrids.

DOI

10.22159/ajpcr.2017.v10i7.18461

Date

01-07-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 7 July 2017 Page: 38-43

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

234 Views | 216 Downloads

Authors & Affiliations

Sunny Jalhan
Department of Pharmacy, Chandigarh Group of College, Landran, Mohali, Punjab, India
India

Sukhdev Singh
Department of Pharmacy, Chandigarh Group of College, Landran, Mohali, Punjab, India
India

Rupinder Saini
Department of Pharmacy, Chandigarh Group of College, Landran, Mohali, Punjab, India
India

Navdeep Singh Sethi
Department of Pharmacy, Doaba College of Pharmacy, Kharar, Mohali, Punjab, India.
India

Upendra K Jain
Department of Pharmacy, Chandigarh Group of College, Landran, Mohali, Punjab, India
India


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