RADIATION THERAPY-INDUCED SUBACUTE INTESTINAL OBSTRUCTION

Authors

  • Rupam G Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
  • Balaji O Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
  • Sereen Rt Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
  • Navin Patil Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i7.18520

Keywords:

Intestinal obstruction, Radiotherapy, Radiation enteritis, Adverse reaction

Abstract

Radiation therapy is an important treatment modality for malignancies of the cervix, uterus, prostate, bladder, testes, and rectum. The incidence of clinically significant radiation-related complications is about 5-20%. Radiation insult to gastrointestinal tract includes damage to the small bowel, colon, and rectum. Predisposing risk factors such as previous surgery, hypertension, diabetes, smoking, hyperbaric oxygen increases the severity of damage as well as the use of other chemotherapeutic agents increases the sensitivity to radiation. Radiation-induced injury can be acute or chronic depending on the mitotic activity of intestinal tissue. Radiation enteritis is usually managed conservatively at the start, but surgery is indicated when complications arise. Hereby, we report a case of subacute intestinal obstruction after 3 weeks of radiotherapy.

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References

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Published

01-07-2017

How to Cite

G, R., B. O, S. Rt, and N. Patil. “RADIATION THERAPY-INDUCED SUBACUTE INTESTINAL OBSTRUCTION”. Asian Journal of Pharmaceutical and Clinical Research, vol. 10, no. 7, July 2017, pp. 7-8, doi:10.22159/ajpcr.2017.v10i7.18520.

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