BIOLOGICAL ACTIVITIES OF GARCINIA MANGOSTANA


Jebalsy Lalitha, Prince Clarance P, Jerin Sales T, Mary Archana A, Agastian P

Abstract


 

 Objective: The aim of the present study was to investigate in vitro antibacterial, antifungal, and antioxidant activities of different solvent extracts of Garcinia mangostana leaves.

Methods: The powdered leaf was subjected to sequential extraction using hexane, ethyl acetate (EA), and methanol. The extracts were subjected to quantitative and qualitative phytochemical analysis, antimicrobial, and antioxidant activities. The best solvent extract was subjected to gas chromatography–mass spectrometry (GC-MS) analysis.

Results: The highest activity was recorded in EA extract which was subjected to GC-MS analysis revealing the presence of squalene (17.09%).

Conclusion: From this present study, we conclude that EA is the best solvent for extracting antimicrobial and antioxidant compounds from the leaves of G. mangostana.


Keywords


Antibacterial activity, Antifungal activity, Phytochemical assay, Antioxidant activity, Gas chromatography–mass spectrometry analysis, Garcinia mangostana.

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References


Attele AS, Zhou YP, Xie JT, Wu JA, Zhang L, Dey L, et al. Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes 2002;51(6):1851-8.

Gryglewski RJ, Korbut R, Robak J, Swies J. On the mechanism of antithrombotic action of flavonoids. Biochem Pharmacol 1987;36(3):317-22.

Akao Y, Nakagawa Y, Iinuma M, Nozawa Y. Anti-cancer effects of xanthones from pericarps of mangosteen. Int J Mol Sci 2008;9(3):355-70.

Kanchanapoom K, Kanchanapoom M. Mangosteen. In: Shaw PE, Chan HT Jr, Nagy S, editors. Tropical and Subtropical Fruits. Vol. 15. Auburndale, Florida: AG Science, Inc.; 1998. p. 68-74.

Saito M, Ogino S, Kubo K, Nagata J, Takeuchi M. High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis. Food Chem Toxicol 2005;43(3):411-9.

Gutierrez-Orozco F, Failla ML. Biological activities and bioavailability of mangosteen xanthones: A critical review of the current evidence. Nutrients 2013;5(8):3163-83.

Akao Y, Nakagawa Y, Iinuma M, Nozawa Y. Anti-cancer effects of xanthones from pericarps of mangosteen. Int J Mol Sci 2008;9(3):355-70.

Bindu AR, Rosemary J, Akhila S. Antimicrobial activity screening of M. minuta extracts. Int J Pharm Pharm Sci 2014;6:581-3.

Sunil C, Ignacimuthu S, Agastian P. Antidiabetic effect of Symplocos cochinchinensis (Lour.) S. Moore. In Type 2 diabetic rats. J Ethnopharmacol 2011;134:298-304.

Glorybal L, Kannana KB, Arasu MV, AL-Dhabi NA, Agastian P. Some biological activities of Epaltes divarcata L.-an in vitro study annals os clinical microbiology and antimicrobials. Ann Clin Microbiol Antimicrob 2015;14:1-14.

Nimal Christhudas IV, Praveen Kumar P, Sunil C, Vajravijayan S, Lakshmi Sundaram R, Jenifer Siril S, et al. In vitro studies on a-glucosidase inhibition, antioxidant and free radical scavenging activities of Hedyotis biflora L. Food Chem 2013;138(2-3):1689-95.

Murray PR, Baron EJ, Pfaller MA, Tenover FC, Yolke RH. Manual of Clinical Microbiology. 6th ed. Washington, D.C: American Society for Microbiology; 1995.

Pinto E, Pina-Vaz C, Salgueiro L, José Gonçalves M, Costa-de-Oliveira S, Cavaleiro C, et al. Antifungal activity of the essential oil of Thymus pulegioides on Candida, Aspergillus and dermatophyte species. J Med Microbiol 2006;55:1367-73.

Pfaller MA, Messer SA, Coffmann S. Comparison of visual and spectrophotometric methods of MIC endpoint determinations by using broth microdilution methods to test five antifungal agents, including the new triazole D0870. J Clin Microbiol 1995;33(5):1094-7.

Wadood A, Ghufran M, Jamal SB, Naeem M, Khan A, Ghaffar R, et al. Phytochemical analysis of medicinal plants occurring in local area of Mardan. Biochem Anal Biochem 2013;2:1-4.

Hepsibah AH, Jothi GJ. A comparative study on the effect of solvents on the phytochemical profile and biological potential of Ormocarpum cochinchinense Auct. Non (Lour.) Merrill. Int J Pharm Pharm Sci 2017;9:67-72.

Slinkard K, Singleton VL. Total phenol analyses: Automation and comparison with manual methods. Am J Enol Viticult 1977;8:4955.

Hanato T, Kagawa H, Yasuhara T, Okuda T. Two new flavonoids and other constituents in licorice root: Their relative astringency and radical scavenging effects. Chem Pharm Bull (Tokyo) 1988;36:2090-7.

Elizabeth K, Rao MN. Oxygen scavenging activity of curcumin. Int J Pharm 1990;58:237-40.

Smirnoff N, Cumbes QJ. Hydroxyl radial scavenging activity of compatible solutes. Phytochemistry 1989;25:1057-60.

Krishnaiah D, Sarbatly R, Bono A. Phytochemical antioxidants for health and medicine: A move towards nature. Biotechnol Mol Biol Rev 2007;1:97-104.

Marxen K, Vanselow KH, Lippemeier S, Hintze R, Ruser A, Hansen UP. Determination of DPPH radical oxidation on caused by metabolic extracts of some microalgal species by linear regression analysis of spectrophotometric measurements. Sensors 2007;7:2080-95.

Aruoma OI. Free radicals, oxidative stress and antioxidants in human health and disease. J Am Oil Chem Soc 1998;75:199-212.

Steer P, Millgård J, Sarabi DM, Basu S, Vessby B, Kahan T, et al. Cardiac and vascular structure and function are related to lipid peroxidation and metabolism. Lipids 2002;37(3):231-6.

Arora S, Brits E, Kaur S, Kaur K, Sohi RS, Kumar S, et al. Evaluation of genotoxicity of medicinal plant extracts by the comet and VITOTOX tests. J Environ Pathol Toxicol Oncol 2005;24(3):193-200.

Inglis TJ. Microbiology and infection. A Clinically Oriented Core Text with Self-Assessment. New York: Churchill Livingstone, Long Man Singapore Publishers (Pte)Ltd; 1996.

Bannister BA, Begg NT, Gillespie SH. Infectious Disease. 2nd ed. Osney Mead, Oxford: Blackwell Science Ltd.; 2000.




About this article

Title

BIOLOGICAL ACTIVITIES OF GARCINIA MANGOSTANA

Keywords

Antibacterial activity, Antifungal activity, Phytochemical assay, Antioxidant activity, Gas chromatography–mass spectrometry analysis, Garcinia mangostana.

DOI

10.22159/ajpcr.2017.v10i9.18585

Date

01-09-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 9 September 2017 Page: 272-278

Print ISSN

0974-2441

Online ISSN

2455-3891

Authors & Affiliations

Jebalsy Lalitha
Research Department of Plant Biology and Biotechnology, Loyola College, Chennai - 600 034, Tamil Nadu, India.
India

Prince Clarance P
Research Department of Plant Biology and Biotechnology, Loyola College, Chennai - 600 034, Tamil Nadu, India.
India

Jerin Sales T
Research Department of Plant Biology and Biotechnology, Loyola College, Chennai - 600 034, Tamil Nadu, India.
India

Mary Archana A
Research Department of Plant Biology and Biotechnology, Loyola College, Chennai - 600 034, Tamil Nadu, India.
India

Agastian P
Research Department of Plant Biology and Biotechnology, Loyola College, Chennai - 600 034, Tamil Nadu, India.
India


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