SENSITIVE SPECTROPHOTOMETRIC ASSAY OF MUSCARINIC RECEPTOR ANTAGONIST TOLTERODINE TARTRATE IN BULK DRUG AND PHARMACEUTICAL FORMULATIONS


Ragaa El-sheikh, Wafaa S Hassan, Ayman A Gouda, Marwa M El-gabry

Abstract


Objective: Simple, sensitive, and accurate spectrophotometric methods have been developed for the assay of tolterodine tartrate (TOL) in bulk drugand pharmaceutical formulations.

Methods: The proposed methods are based on oxidation reaction of TOL with a known excess of cerium(IV) ammonium sulfate as an oxidizing agentin acid medium followed by determination of unreacted oxidant by adding a fixed amount of dye, e.g., amaranth (AM), rhodamine 6G (Rh6G), andindigo carmine (IC) followed by measuring the absorbance at 520, 530, and 610 nm, respectively. The effect of experimental conditions was studiedand optimized.

Results: The Beer’s law was obeyed in the concentration ranges of 1.0-10, 1.0-12, and 0.5-9.0 μg/mL using AM, Rh6G, and IC dyes, respectively, witha correlation coefficient ≥0.9995. The calculated molar absorptivity values are 1.868×104, 1.008×104, and 1.623×104 L/mol/cm using AM, Rh6G, andIC dyes, respectively. The limits of detection and quantification were reported. Intraday and interday accuracy and precision of the methods have beenevaluated. No interference was observed from the additives.

Conclusion: The proposed methods were successfully applied to the assay of TOL in tablets preparations, and the results were statistically comparedwith those of the reported method by applying Student’s t-test and F-test. The reliability of the methods was further ascertained by performingrecovery studies using the standard addition method.


Keywords


Tolterodine tartrate, Spectrophotometry, Cerium(IV) ammonium sulfate, Dyes, Tablets.

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About this article

Title

SENSITIVE SPECTROPHOTOMETRIC ASSAY OF MUSCARINIC RECEPTOR ANTAGONIST TOLTERODINE TARTRATE IN BULK DRUG AND PHARMACEUTICAL FORMULATIONS

Keywords

Tolterodine tartrate, Spectrophotometry, Cerium(IV) ammonium sulfate, Dyes, Tablets.

DOI

10.22159/ajpcr.2017.v10i8.18794

Date

01-08-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 8 August 2017 Page: 346-352

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

58 Views | 127 Downloads

Authors & Affiliations

Ragaa El-sheikh
Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt
Egypt

Wafaa S Hassan
Department of Analytical Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Egypt

Ayman A Gouda
Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt
Egypt

Marwa M El-gabry
Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt
Egypt


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