Mifetika Lukitasari, Dwi Adi Nugroho, Mohammad Saifur Rohman, Nur Ida Panca Nugrahini, Teguh Wahyu Sardjono



 Objective: The objective of this study is to investigate the effect of light-roasted green coffee bean extract (GCE) administration for 7 weeks on the improvement of metabolic profile, adiponectin level, homeostatic model assessment insulin resistance (HOMA-IR) index in metabolic syndrome (MS) rat model.

Methods: Adult male Sprague-Dawley rats were induced by a combination of high sucrose and high-fat diet for 8 weeks and streptozotocin injection in the 2nd week. The MS was confirmed by NCEP-ATP III criteria. They were divided into six weight-matched groups (n=5), normal control, MS, metformin and simvastatin-treated group (DMS), 100 and 200/body weight (bw) GCE (GCE 100 and GCE 200, respectively). The extracts were given through oral gavage daily for 7 weeks. The effect of GCE on body weight, serum glucose, triglyceride, (TG) and high-density lipoprotein (HDL) level was analyzed by colorimetric method. HOMA-IR index and adiponectin were analyzed by enzyme-linked immunosorbent assay methods.

Result: Fasting blood glucose, TG, and systolic blood pressure decreased significantly (p<0.05) in both GCE groups. Moreover, after 7 weeks, those parameters were significantly lower (p<0.05) compared to that of MS group. Only GCE 100 group that showed a significant decrease in HDL level. GCE 100 mg/bw and 200 mg/bw group showed significantly higher adiponectin level compared to that of MS and DMS group. Furthermore, GCE 100, GCE 200, and DMS group showed a significant lower HOMA-IR index compared to that of MS group.

Conclusion: 7 weeks GCE administration could decrease fasting blood glucose, profile lipid, blood pressure, and improved adiponectin level and HOMA-IR index.


Metabolic syndrome, Green coffee bean extract, Adiponectin, Homeostatic model assessment insulin resistance.

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Metabolic syndrome, Green coffee bean extract, Adiponectin, Homeostatic model assessment insulin resistance.





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Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 9 September 2017 Page: 279-283

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Authors & Affiliations

Mifetika Lukitasari
Department of Nursing, Faculty of Medicine, Brawijaya University

Dwi Adi Nugroho
Departement of Basic Medical Science and Biomedicine, Faculty of Medicine GajahMada University

Mohammad Saifur Rohman
Department of Cardiology and Vascular Medicine, Faculty of Medicine Brawijaya University-Saiful Anwar General Hospital

Nur Ida Panca Nugrahini
Department of Agricultural Product Technology, Faculty of Agricultural Technology, Brawijaya University

Teguh Wahyu Sardjono
5Department of Clinical Paracytology, Faculty of Medicine Brawijaya University

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