G. Vinitha, P Vani, N Manikandan


Chemical reducing and capping reagents are largely used in synthesizing metal oxide nanoparticles which limits the biomedical applications. Researchers have recently found out the eco-friendly technique of green synthesis which enhances the unique physical and chemical properties of nanomaterials. In this critique, we discuss green route to synthesize metal oxide nanoparticles and its significant applications in various fields of energy and environment, aerospace, medicine, biotechnology, etc.This study arouses to provoke new research design of approach to synthesize nanoparticles for various technological applications. In this review, most of the metal oxides nanoparticles with different plant extract with enhanced properties for its potential applications are discussed which confirms plant extracts as a potential candidate to be used as reducing and capping agent.

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Zhang J, Gao L. Synthesis and characterization of nanocrystalline tin oxide by sol-gel method. J Solid State Chem 2004;177(4):1425-30.

Ramimoghadam D, Bin Hussein MZ, Taufiq-Yap YH. Hydrothermal synthesis of zinc oxide nanoparticles using rice as soft biotemplate. Chem Cent J 2013;7:136.

Singh AK, Nakate UT. Microwave synthesis, characterization and photocatalytic properties of SnO2 nanoparticles. Adv Nanopart 2013;2(1):66-70.

Kandpal ND, Sah N, Loshali R, Joshi R, Prasad J. Coprecipitation method of synthesis and characterization of iron oxide nanoparticles. J Sci Ind Res 2014;73:87-90.

Guo J, Li Y, Zhu S, Chen Z, Liu Q, Zhang D, et al. Synthesis of WO3@ graphene composite for enhanced photocatalytic oxygen evolution from water. RSC Adv 2012;2(4):1356-63.

Sun C, Li H, Zhang H, Wang Z, Chen L. Controlled synthesis of CeO2 nanorods by a solvothermal method. Nanotechnology 2005;16(9):1454.

Boutinguiza M, Rodriguez-Gonzalez B, del Val J, Comesaña R, Lusquiños F, Pou J. Production of TiO 2 crystalline nanoparticles by laser ablation in ethanol. Appl Surf Sci 2012;258(23):9484-6.

Kobayashi Y, Abe Y, Maeda T, Yasuda Y, Morita T. A metal-metal bonding process using metallic copper nanoparticles produced by reduction of copper oxide nanoparticles. J Mater Res Technol 2014;3(2):114-21.

Shahmiri M, Ibrahim NA, Faraji N, Yunus WM, Asim N, Zainuddin N. Third-order nonlinear optical properties of chemically synthesized copper oxide nanosheets. Phys E Low Dimens Sys Nanostruct 2013;54:109-14.

Abboud Y, Saffaj T, Chagraoui A, El Bouari A, Brouzi K, Tanane O, et al. Biosynthesis, characterization and antimicrobial activity of copper oxide nanoparticles (CONPs) produced using brown alga extract (Bifurcaria bifurcata). Appl Nanosc 2014;4(5):571-6.

Jha AK, Prasad K, Kulkarni AR. Synthesis of TiO 2 nanoparticles using microorganisms. Colloids Surf B Biointerfaces 2009;71(2):226-9.

Dhoondia ZH, Chakraborty H. Lactobacillus mediated synthesis of silver oxide nanoparticle. Nanomater Nanotechnol 2012;2:2-15.

Baskar G, Chandhuru J, Fahad KS, Praveen AS. Mycological synthesis, characterization and antifungal activity of zinc oxide nanoparticles. Asian J Pharm Technol 2013;3(4):142-6.

Munusamy S, Bhakyaraj K, Vijayalakshmi L, Stephen A, Narayanan V. Synthesis and characterization of cerium oxide nanoparticles using Curvularia lunata and their antibacterial properties. Int J Innov Res Sci Eng 2014;129:255-8.

Nasrollahzadeh M, Sajadi SM. Synthesis and characterization of titanium dioxide nanoparticles using Euphorbia heteradena Jaub root extract and evaluation of their stability. Ceram Int 2015;41(10):14435-9.

Dobrucka R, Dlugaszewska J. Biosynthesis and antibacterial activity of ZnO nanoparticles using Trifolium pratense flower extract. Saudi J Biol Sci 2016;23:517-23.

Sundrarajan M, Ambika S, Bharathi K. Plant-extract mediated synthesis of ZnO nanoparticles using Pongamia pinnata and their activity against pathogenic bacteria. Adv Powder Technol 2015;26(5):1294-9.

Ramesh P, Rajendran A, Subramanian A. Synthesis of zinc oxide nanoparticle from fruit of Citrus aurantifolia by chemical and green method. Asian J Phytomed Clin Res 2014;2(4):189-95.

Ambika S, Sundrarajan M. Green biosynthesis of ZnO nanoparticles using Vitex negundo L. extract: Spectroscopic investigation of interaction between ZnO nanoparticles and human serum albumin. J Photochem Photobiol B Biol 2015;149:143-8.

Bhuyan T, Mishra K, Khanuja M, Prasad R, Varma A. Biosynthesis of zinc oxide nanoparticles from Azadirachta indica for antibacterial and photocatalytic application. Mater Sci Semicond Process 2015;32:55-61.

Priya GS, Kanneganti A, Kumar KN, Rao KV, Bykkam S. Biosynthesis of cerium oxide nanoparticles using Aloe barbadensis miller gel. Int J Sci Res Publ 2014;4:2250-3153.

Arumugam A, Karthikeyan C, Hameed AS, Gopinath K, Gowri S, Karthika V. Synthesis of cerium oxide nanoparticles using Gloriosa superba L. leaf extract and their structural, optical and antibacterial properties. Mater Sci Eng C 2015;49:408-15.

Sharma JK, Srivastava P, Singha G, Akhtar MS, Ameen S. Green synthesis of CO3O4 nanoparticles and their applications in thermal decomposition of ammonium perchlorate and dye-sensitized solar cells. Mater Sci Eng 2015;193:181-8.

Diallo A, Beye AC, Doyle TB, Park E, Maaza M. Green synthesis of CO3O4 nanoparticles via Aspalathus linearis: Physical properties. Green Chem Lett Rev 2015;8:3-4, 30-6.

Upadhyay RK, Soin N, Bhattacharya G, Saha S, Barman A, Roy SS. Grape extract assisted green synthesis of reduced graphene oxide for water treatment application. Mater Lett 2015;160:355-8.

Maddinedi SB, Mandal BK, Vankayala R, Kalluru P, Pamanji SR. Bioinspired reduced graphene oxide nanosheets using Terminalia chebula seeds extract. Spectrochim Acta A Mol Biomol Spectrosc 2015;145:117-24.

Khan MY, Mangrich AS, Schultz J, Grasel FS, Mattoso N, Mosca DH. Green chemistry preparation of superparamagnetic nanoparticles containing Fe3O4 cores in biochar. J Anal Appl Pyrolysis 2015;116:42-8.

Ehrampoush MH, Miria M, Salmani MH, Mahvi AH. Cadmium removal from aqueous solution by green synthesis iron oxide nanoparticles with tangerine peel extract. J Environ Health Sci Eng 2015;13:84.

Latha N, Gowri M. Bio synthesis and characterisation of Fe3O4 nanoparticles using Caricaya papaya Leaves extract. Int J Sci Res 2014;12:17.

Maensiri S, Laokul P, Klinkaewnarong J, Phokha S, Promarak V, Seraphin S. Indium oxide (In2O3) nanoparticles using Aloe vera plant extract: Synthesis and optical properties. J Optoelectron Adv Mater 2008;10:161-5.

Awwad AM, Ahmad AL. Biosynthesis, characterization, and optical properties of magnesium hydroxide and oxide nanoflakes using Citrus limon leaf extract. Arab J Phys Chem 2014;2:65-70.

Moorthy SK, Ashok CH, Rao KV, Viswanathan C. Synthesis and characterization of MgOnanoparticles by neem leaves through green method. Mater Today Proc 2015;2(9):4360-8.

Srivastava V, Sharma YC, Sillanpä M. Green synthesis of magnesium oxide nanoflower and its application for the removal of divalent metallic species from synthetic wastewater. Ceram Int 2015;41(5):6702-9.

Kannan SK, Sundrarajan M. Green synthesis of ruthenium oxide nanoparticles: Characterization and its antibacterial activity. Adv Powder Technol 2015;26(6):1505-11.

Jayaseelan C, Rahuman AA, Roopan SM, Kirthi AV, Venkatesan J, Kim SK, et al. Biological approach to synthesize TiO2 nanoparticles using Aeromonas hydrophila and its antibacterial activity. Spectrochim Acta A Mol Biomol Spectrosc 2013;107:82-9.

Subhashini D, Nachiyar SV. Albizia saman: A green route for the reduction of bulk TiO2. Int J Chemtech Res 2014;6:5137-41.

Naik GK, Mishra PM, Parida K. Green synthesis of Au/TiO2 for effective dye degradation in aqueous system. Chem Eng J 2013;229:492-7.

Kumar PS, Francis AP, Devasena T. Comparative studies on green synthesized and chemically synthesized titanium oxide nanoparticles: A validation for green synthesis protocol using hibiscus flower. J Environ Nanotechnol 2014;3(4):78-85.

Sundrarajan M, Gowri S. Green synthesis of titanium dioxide nanoparticles by Nyctanthes arbor-tristis Leaves extract. Chalcogenide Lett 2011;8(8):447-51.

Sivaraj R, Rahman PK, Rajiv P, Narendhran S, Venckatesh R. Biosynthesis and characterization of Acalypha indica mediated copper oxide nanoparticles and evaluation of its antimicrobial and anticancer activity. Spectrochim Acta A Mol Biomol Spectrosc 2014;129:255-8.

Gunalan S, Sivaraj R, Venckatesh R. Aloe barbadensis Miller mediated green synthesis of mono-disperse copper oxide nanoparticles: Optical properties. Spectrochim Acta A Mol Biomol Spectrosc 2012;97:1140-4.

Kumar B, Smita K, Cumbal L, Debut A, Angulo Y. Biofabrication of copper oxide nanoparticles using Andean blackberry (Rubus glaucus Benth.) fruit and leaf. J Saudi Chem Soc 2015;30:30.

Sharma JK, Akhtar MS, Ameen S, Srivastava P, Singh G. Green synthesis of CuO nanoparticles with leaf extract of Calotropis gigantea and its dye-sensitized solar cells applications. J Alloys Compd 2015;632:321-5.

Mohan S, Singh Y, Verma DK, Hasan SH. Synthesis of CuO nanoparticles through green route using Citrus limon juice and its application as nanosorbent for Cr (VI) remediation: Process optimization with RSM and ANN-GA based model. Process Saf Environ Prot 2015;96:156-66.

Nasrollahzadeh M, Sajadi SM, Rostami-Vartooni A. Green synthesis of CuO nanoparticles by aqueous extract of Anthemis nobilis flowers and their catalytic activity for the A³ coupling reaction. J Colloid Interface Sci 2015;459:183-8.

Nasrollahzadeh M, Maham M, Sajadi SM. Green synthesis of CuO nanoparticles by aqueous extract of Gundelia tournefortii and evaluation of their catalytic activity for the synthesis of N-monosubstituted ureas and reduction of 4-nitrophenol. J Colloid Interface Sci 2015;455:245-53.

Nethravathi PC, Kumar MA, Suresh D, Lingaraju K, Rajanaika H, Nagabhushana H, et al. Tinospora cordifolia mediated facile green synthesis of cupric oxide nanoparticles and their photocatalytic, antioxidant and antibacterial properties. Mater Sci Semicond Process 2015;33:81-8.

Nasrollahzadeh M, Sajadi SM, Rostami-Vartooni A, Bagherzadeh M, Safari R. Immobilization of copper nanoparticles on perlite: Green synthesis, characterization and catalytic activity on aqueous reduction of 4-nitrophenol. J Mol Catal A Chem 2015;400:22-30.

Sivaraj R, Rahman PK, Rajiv P, Salam HA, Venckatesh R. Biogenic copper oxide nanoparticles synthesis using Tabernaemontana divaricate leaf extract and its antibacterial activity against urinary tract pathogen. Spectrochim Acta A Mol Biomol Spectrosc 2014;133:178-81.

Nasrollahzadeh M, Sajadi SM, Rostami-Vartooni A, Bagherzadeh M. Green synthesis of Pd/CuO nanoparticles by Theobroma cacao L. seeds extract and their catalytic performance for the reduction of 4-nitrophenol and phosphine-free Heck coupling reaction under aerobic conditions. J Colloid Interface Sci 2015;448:106-13.

Anbuvannan M, Ramesh M, Viruthagiri G, Shanmugam N, Kannadasan N. Anisochilus carnosus leaf extract mediated synthesis of zinc oxide nanoparticles for antibacterial and photocatalytic activities. Mater Sci Semicond Process 2015;39:621-8.

Suresh D, Shobharani RM, Nethravathi PC, Pavan Kumar MA, Nagabhushana H, Sharma SC. Artocarpus gomezianus aided green synthesis of ZnO nanoparticles: Luminescence, photocatalytic and antioxidant properties. Spectrochim Acta A Mol Biomol Spectrosc 2015;141:128-34.

Divyapriya S, Sowmia C, Sasikala S. Synthesis of zinc oxide nanoparticles and antimicrobial activity of Murraya koeniggii. World J Pharm Pharm Sci 2014;3(12):1635-45.

Nethravathi PC, Shruthi GS, Suresh D, Nagabhushana H, Sharma SC. Garcinia xanthochymus mediated green synthesis of ZnO nanoparticles: Photoluminescence, photocatalytic and antioxidant activity studies. Ceram Int 2015;41:8680-7.

Senthilkumar SR, Sivakumar T. Green tea (Camellia sinensis) mediated synthesis of zinc oxide (ZnO) nanoparticles and studies on their antimicrobial activities. Int J Pharm Pharm Sci 2014;6(6):461-5.

Elumalai K, Velmurugan S, Ravi S, Kathiravan V, Ashokkumar S. Retracted: Green synthesis of zinc oxide nanoparticles using Moringa oleifera leaf extract and evaluation of its antimicrobial activity. Spectrochim Acta A Mol Biomol Spectrosc 2015;143:158-64.

Fu L, Fu Z. Plectranthus amboinicus leaf extract-assisted biosynthesis of ZnO nanoparticles and their photocatalytic activity. Ceram Int 2015;41(2):2492-6.

Samat NA, Nor RM. Sol-gel synthesis of zinc oxide nanoparticles using Citrus aurantifolia extracts. Ceram Int 2013;39(1):S545-8

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Asian Journal of Pharmaceutical and Clinical Research
Special Issue April 2017 Page: 337-343

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Authors & Affiliations

G. Vinitha
School of Advanced Sciences, VIT University- Chennai, Tamilnadu

P Vani
School of Advanced Sciences, VIT University- Chennai, Tamilnadu

N Manikandan
School of Advanced Sciences, VIT University- Chennai, Tamilnadu

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