FORMULATION OF NANOPARTICLES OF ANTI-MIGRAINE DRUGS TRIPTANS BY COACERVATION METHOD


Farshid A, Lakshmi Csr

Abstract


 

 Objective: Triptans are effective medicines used to treat migraine and certain other headaches. This study has been conducted to prepared nanoparticles (NPs) of triptans by coacervation technique using a different drug to polymer ratios and evaluated.

Methods: Polymers such as albumin and gelatin and cross-linking agent were used at different levels to prepare triptan NPs with high entrapment efficiency (EE) and low particle size (PS). Completion of the reaction was confirmed by infrared spectra. NPs were evaluated for shape and surface morphology, polydispersity index, zeta potential, EE, and PS distribution.

Results: Among all the formulation, AA5 formulation of triptan-loaded albumin NPs (ANPs) has small PS and high EE.

Conclusion: In this study, we have found that the ANPs in the presence of 4% glutaraldehyde as a cross-linking agent could be used as a delivery vehicle of triptans.


Keywords


Triptan, Nanoparticles, Albumin and Gelatin, Coacervation method.

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About this article

Title

FORMULATION OF NANOPARTICLES OF ANTI-MIGRAINE DRUGS TRIPTANS BY COACERVATION METHOD

Keywords

Triptan, Nanoparticles, Albumin and Gelatin, Coacervation method.

DOI

10.22159/ajpcr.2017.v10i11.20302

Date

01-11-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 11 November 2017 Page: 122-128

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

14 Views | 57 Downloads

Authors & Affiliations

Farshid A
Department of Pharmaceutics, Nargund College of Pharmacy, Bengaluru, Karnataka, India
India

Lakshmi Csr
Department of Pharmaceutics, Nargund College of Pharmacy, Bengaluru, Karnataka, India
India


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