FORMULATION OF NANOPARTICLES OF ANTI-MIGRAINE DRUGS TRIPTANS BY COACERVATION METHOD
Â Objective: Triptans are effective medicines used to treat migraine and certain other headaches. This study has been conducted to prepared nanoparticles (NPs) of triptans by coacervation technique using a different drug to polymer ratios and evaluated.
Methods: Polymers such as albumin and gelatin and cross-linking agent were used at different levels to prepare triptan NPs with high entrapment efficiency (EE) and low particle size (PS). Completion of the reaction was confirmed by infrared spectra. NPs were evaluated for shape and surface morphology, polydispersity index, zeta potential, EE, and PS distribution.
Results: Among all the formulation, AA5 formulation of triptan-loaded albumin NPs (ANPs) has small PS and high EE.
Conclusion: In this study, we have found that the ANPs in the presence of 4% glutaraldehyde as a cross-linking agent could be used as a delivery vehicle of triptans.
2. Keam S, Goa K, Figgitt D. Almotriptan: A review of its use in a migraine. Headache. J Head Face Pain 2003;43:300-1.
3. Mark H, Kim P. Drug Class Review Triptans. Vol. 4. Portland, OR: Oregon Health and Science University; 2009. p. 5-6.
4. Yadav BV, Ravichandiran V, Kumar SS. Preparation and characterization of gemcitabine loaded MPEG-PCL polymeric nanoparticles for improved transportation across blood brain barrier. Int J Pharm Pharm Sci 2016;8:83-90.
5. Mistry A, Stolnik S, Illum L. Nanoparticles for direct nose-to-brain delivery of drugs. Int J Pharm 2009;379(1):146-57.
6. Wong HL, Wu XY, Bendayan R. Nanotechnological advances for the delivery of CNS therapeutics. Adv Drug Deliv Rev 2012;64(7):686-700.
7. Jawahar N. Development and characterization of PLGA nanoparticles containing carvedilol. J Pharm Sci Res 2009;1(3):123-8.
8. Saikat D, Rinti B, Jayesh B. Aspirin Loaded Albumin Nanoparticles by Coacervation: Implications in Drug Delivery. Vol. 18. Bombay: School of Biosciences and Bioengineering, Indian Institute of Technology; 2005. p. 202-11.
9. Ankarao A, Vasu VN, Hanumantha KR. Formulation and in-vitro evaluation of oral sustained release nano particulate delivery system of carvedilol. Int J Res Pharm Biomed Sci 2012;3:923-4.
10. Young W, Yong HK. Preparation and cytotoxicity comparison of Type A gelatin nanoparticles with recombinant human gelatin nanoparticles. Macromol Res 2009;17(7):464-8.
11. Azimi B, Nourpanah P, Rabiee M, Arbab S. Producing gelatin nanoparticles as delivery system for bovine serum albumin. Iran Biomed J 2014;18(1):34-40.
12. Azarmi S, Huang Y, Chen H, McQuarrie S, Abrams D, Roa W, et al. Optimization of a two-step desolvation method for preparing gelatin nanoparticles and cell uptake studies in 143B osteosarcoma cancer cells. J Pharm Pharm Sci 2006;9(1):124-32.
13. Calvo P, Remunan-Lopez C, Vila-Jato JL, Alonso MJ. Novel hydrophilic chitosan polyethylene oxide nanoparticles as protein carriers. J Appl Polym Sci 1997;63(1):125-32.
14. Gaurav K. Mannosylated gelatin nanoparticles bearing isoniazid for selective management of tuberculosis. J Drug Target 2011;19(3):219-27.
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