EVALUATION OF ANTIMICROBIAL AND SYNERGISTIC ANTIMICROBIAL PROPERTIES OF PTEROCARPUS SANTALINUS
Keywords:Pterocarpus santalinus, Synergistic antimicrobial activity, Antibiotics, Bark, Fluconazole
Objectives: The aim of the present study was to evaluate antibacterial and synergistic antimicrobial properties of leaf, stem and bark of Pterocarpus santalinus. Methods: The extraction was done by decoction method. The antimicrobial activity was done by agar well diffusion assay and the synergistic antimicrobial activity was done by agar disc diffusion assay.Â Results: The synergistic activity was studied with plant extracts plus antibiotics viz. Ampicillin , Polymyxin-B,Â Clotrimazole and Â Fluconazole.Â Conclusions: Amongst the three parts, the best antimicrobial activity was shown by bark extract. All the three parts showed synergistic antimicrobial activity with antibiotics but their level varied. Â The results suggest that all the three parts phytochemicals that enhance the antimicrobial efficacy of the antibiotics against some microorganisms and hence can be developed as a new therapeutic weapon against infectious diseases.
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