PHARMACEUTICAL STANDARDIZATION OF PANCHAGUNA TAILA (MEDICATED OIL) AND PRODUCT DEVELOPMENT AS OINTMENT, GEL, CREAM, AND PHYSIOWAX

  • Sweta Kumari Department of Ayurvedic Pharmacy, School of Pharmaceutical Sciences, Lovely Professional University, Punjab - 144411, India.
  • Dileep Singh Baghel Department of Ayurvedic Pharmacy, School of Pharmaceutical Sciences, Lovely Professional University, Punjab - 144411, India.

Abstract

 

 Objective: The present study aimed to prepare Panchaguna taila (PGT) and its development in various dosage forms, i.e. ointment, gel, cream, and physiowax to exemplify the characteristic parameters according to pharmaceutical standards.

Methods: PGT is polyherbal medicated oil used externally for treating wounds, cut, and burn and used for massaging in rheumatoid arthritis, muscular pain, sprains, and joints pain. Prepare the decoction using Haritaki, Vibhitaki, Amalaki, Nimba, Sambhalu and prepare paste (kalka) from Madhuchishta, Gandhaphiroja, Shilarasa, Rala, and Guggulu. Mix all the ingredients and heat till watery portion not evaporated from the oil with constant stirring then filter it. Add eucalyptus oil, turpentine oil, and kejoputi oil at the end and stir it well. Prepare various dosage forms like ointment, gel, cream, and physiowax using suitable base for the better and improved therapeutic application. Analytical standards for PGT such as acid value, saponification value, iodine value, and peroxide value were performed, and obtained results were appeared under the prescribed limit of the official monograph. Various physicochemical parameters such as homogeneity, spreadability, pH, and melting point were performed for PGT ointment, PGT gel, PGT cream, and PGT physiowax. Stability study of PGT was done for 3 days under the accelerated conditions.

Results: In PGT, various physicochemical parameters were performed on the interval of 24, 48, and 72 hrs, and no significant variation found in their physicochemical properties when observed values were compared. PGT ointment, PGT gel, PGT cream, and PGT physiowax containing PGT as active pharmaceutical ingredient with various suitable excipients and base are easy to formulate and convenient to apply over the affected area. Rf observed between the ranges 0.21 to 0.84 as given in the standard monograph. In PGT, PGT ointment and PGT physiowax, 10 spots were found, and in PGT gel and PGT cream, 7 spots were found. 0.11, 0.15, and 0.34 spots were found in the PGT gel, PGT cream, and PGT physiowax, respectively, that can be given by the excipients or base used for their preparation.

Conclusion: It is possible to make other dosage form of PGT which can be more convenient to the customers. Hence, the issues related to the PGT like staining and sticking can be resolved by developing or converting the PGT into various convenient dosages.

Keywords: Panchaguna taila, Sneha kalpana, Ointment, Gel, Cream, Physiowax.

Author Biography

Sweta Kumari, Department of Ayurvedic Pharmacy, School of Pharmaceutical Sciences, Lovely Professional University, Punjab - 144411, India.
School of Pharmaceutical Sciences, Asst. Prof

References

1. Sharanagadhara Samhita with Dipika Hindi Commentary”. Vol. Ch. 9. Edited by Brahmanand Tripathi. Varanasi: Chaukhamba Subharti Prakashan, Madhyam Khand; 2008.
2. Anonymous. The Ayurvedic Pharmacopoeia of India, Part I. Vol. I. New Delhi: Government of India, Ministry of Health and Family Welfare, Department of Ayush; 2001. p. 62, 63.
3. Chavan PS, Bhoyar M, Khiyani RM. A critical study on guggulu (Commiphora mukul) - A review. Int J Ayrveda Altern Med 2015;3(3):159-66.
4. Pimpale S, Rao A, Patil A, Desai S. Comparative analytical study of guggulu (Commiphora mukul) Shodhana done in different media. Int Ayurvedic Med J 2014;2(5):2320-5091.
5. Shastri A. Bhaishajya Ratnavali. Varanasi: Chaukhamba Samskarta Samsthana; 2002.
6. Caster SJ. Cooper and Gunn’s Dispensing for Pharmaceutical Studies: Ointments, Pastes, Jellies. 12th ed. India: CBS Publisher & Distributors; 1987. p. 192-210.
7. Sharma PP. Cosmetics for skin. Cosmetics Formulation Manufacturing & Quality Control, Part II. Ch. 7. New Delhi: Vandana Publication; 1998. p. 181.
8. Troy DB, Beringer P. Remington: The Science and Practice of Pharmacy. 21st ed. New Delhi: .2015.
9. Ravindra J, Pratibha RP, Patil PH. Formulation and evaluation of semisolid preparation (ointment, gel & cream) of thiocolchicoside. J Pharm Biomed Sci 2011;8(1):2230-7885.
10. Goriya P, Dhawani HS, Galib R, Shukla VJ, Prajapati PK. Formulation development and preliminary physicochemical characterization of Kustha taila. Int J Res Ayurveda Pharm 2014;5(3):246-51.
11. Khandelwal KR. Practical Pharmacognosy Techniques and Experiments. 12th ed. Pune, India: Nirali Prakashan; 2004.
12. Saklani S, Mishra AP, Sati B, Sati H. Pharamcognostic, phytochemical and antimicrobial screening of Alphanamitis polystachya & endangered medicinal trace. Int J Pharm Pharm Sci 2012;3:975-1491.
13. Anonymous. Protocol for testing Ayurveda, Siddha and Unani Medicines. Ghaziabad: Government of India, Ministry of Health and Family Welfare, Department of AYUSH, PLIM; 2006.
14. Kumar SP, Prasan ND. Development of evaluation of polyherbal syrup from same herbs used as expectorant. World J Pharm Pharm Sci 2013;2(5):3848-53.
15. Mehta NJ, Patadiya ND, Patel J, Shastri DH, Shelet PK. Development and evaluation of a anti-arthritic herbal ointment. Res J Pharm Biol Chem Sci 2013;1(4):975-8585.
16. Anonymous. The Ayurvedic Formulary of India, Part II. Vol. III. New Delhi: Government of India, Ministry of Health and Family Welfare, Department of Ayush; 2010.
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Kumari, S., and D. S. Baghel. “PHARMACEUTICAL STANDARDIZATION OF PANCHAGUNA TAILA (MEDICATED OIL) AND PRODUCT DEVELOPMENT AS OINTMENT, GEL, CREAM, AND PHYSIOWAX”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 16, Sept. 2017, pp. 57-62, doi:10.22159/ajpcr.2017.v10s4.21337.
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