SUCCESSFUL TREATMENT OF VENTILATOR ASSOCIATED PNEUMONIA CAUSED BY MULTIDRUG RESISTANT ACINETOBACTER BAUMANNII WITH A COMBINATION THERAPY OF CSE1034 AND COLISTIN: A CASE REPORT.

  • Himanshu Garg Department of Respiratory, Artemis Hospital, Noida, Uttar Pradesh, India.
  • Pratibha Dogra Department of Respiratory, Artemis Hospital, Noida, Uttar Pradesh, India
  • Mayank Saxena Department of Respiratory, Artemis Hospital, Noida, Uttar Pradesh, India.

Abstract

 Objective: One of the major causes of ventilator-associated pneumonia (VAP) in hospital settings is Acinetobacter baumannii. The propensity of acquiring antimicrobial resistance rapidly through a multiple number of mechanisms makes the selection of an appropriate empirical antimicrobial agent exceedingly challenging for this pathogen.

Methods: The present case report explores the option of treating VAP infection due to carbapenem-resistant pathogens with antibiotic adjuvant entities.

Results: We present a case of VAP due to carbapenem-resistant A. baumannii that was successfully treated with CSE-1034 and colistin combination therapy.

Conclusion: Early recognition and appropriate antibiotic therapy are essential to eliminate poor outcomes in multidrug-resistant (MDR) bacterial infections. The present case highlights the antibiotic adjuvant entity “CSE-1034†as an empiric option for the treatment of VAP due to MDR A. baumannii in intensive care unit.

Keywords: CSE1034, Colistin, Pneumonia, Acinetobacter baumannii, Carbapenamases.

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How to Cite
Garg, H., P. Dogra, and M. Saxena. “SUCCESSFUL TREATMENT OF VENTILATOR ASSOCIATED PNEUMONIA CAUSED BY MULTIDRUG RESISTANT ACINETOBACTER BAUMANNII WITH A COMBINATION THERAPY OF CSE1034 AND COLISTIN: A CASE REPORT.”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, no. 2, Feb. 2018, pp. 1-3, doi:10.22159/ajpcr.2018.v11i2.21619.
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Case Study(s)