CHEMOPROTECTIVE EFFECT OF EDIBLE GASTROPOD, XANCUS PYRUM AND ITS USEFULNESS IN THE AMELIORATION OF CISPLATIN-INDUCED TOXICITY


Bindhu Jayaprakash, Emilin Renitta, Emilin Renitta

Abstract


 

 Objective: The main purpose of this study was to evaluate chemoprotective activities of methanolic extracts of an edible gastropod (Xancus pyrum) in cisplatin-induced immunosuppressed mice.

Methods: Cisplatin (100 mg/kg, intraperitoneally [IP]) induced immunosuppressed mice were treated with a methanolic extract of X. pyrum (0.5 mg/dose/animal/IP) for a period of 10 days. The effect of the extract on lymphoid organ weight, bone marrow cellularity (BMC), alpha esterase activity, and on enzyme levels such as serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, urea, and creatinine was estimated to identify the chemoprotective activity of X. pyrum.

Results: Administration of X. pyrum extract in cisplatin-treated mice, found to enhance the BMC and alpha-esterase positive cells, which were drastically reduced in cisplatin alone treated control animals suggests that cisplatin-induced myelosuppression was reversed or inhibited by X. pyrum extract administration possibly through its chemoprotective activity.

Conclusion: Cisplatin and its metabolites can bind to DNA, causing damage that may result in chromosome breaks, micronucleus formation and cell death. Administration of X. pyrum extract in cisplatin-treated mice, found to enhance the BMC and alpha-esterase positive cells, which were drastically reduced in cisplatin alone treated control animals suggests that cisplatin-induced myelosuppression was reversed or inhibited by X. pyrum extract administration possibly through its chemoprotective activity.


Keywords


Gastropod, Xancus pyrum, Chemoprotective, Cisplatin, Alpha esterase.

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About this article

Title

CHEMOPROTECTIVE EFFECT OF EDIBLE GASTROPOD, XANCUS PYRUM AND ITS USEFULNESS IN THE AMELIORATION OF CISPLATIN-INDUCED TOXICITY

Topics

Research Associate cum Assistant Professor

Keywords

Gastropod, Xancus pyrum, Chemoprotective, Cisplatin, Alpha esterase.

DOI

10.22159/ajpcr.2017.v10i12.21762

Date

01-12-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 12 December 2017 Page: 260-265

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

21 Views | 29 Downloads

Authors & Affiliations

Bindhu Jayaprakash
Department of Biotechnology, Bannari Amman Institute of Technology, Sathyamangalam - 638 401, Erode, Tamil Nadu, India.
India

Emilin Renitta
Department of Biotechnology, Karunya University, Coimbatore - 641 114, Tamil Nadu, India.
India

Emilin Renitta
Department of Biotechnology, Karunya University, Coimbatore - 641 114, Tamil Nadu, India.
India


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