SCREENING AND CONFIRMATION OF DIFFERENT SYNTHETIC ADULTERANTS IN SLIMMING PRODUCTS


Sajad Fakhri, Bahareh Mohammadi, Ronak Jalili, Marziyeh Hajialyani, Gholamreza Bahrami

Abstract


 Objective: The presence of synthetic drugs (as adulterant) in slimming herbal products of world markets has contravened the country’s law and has created many troubles for some consumers of slimming products. This study aims to use a simple and reliable method for simultaneously finding and validating the presence of possible adulterants in some slimming products, which could not be discriminated due to misleading packaging.

Method: Fifteen slimming products were obtained from the Iran pharmaceutical markets. Liquid chromatography-ultraviolet and LC-mass spectrometry methods were performed for simultaneous screening and confirmation of adulterants.

Results: The most abundant adulterant was Phenolphthalein, which has been used in 11 cases of the 15 slimming products. Furthermore, 5 products included caffeine, two included phendimetrazine, and two included protriptyline.

Conclusion: The performed method was successful in detection of different adulterants. According to the presence of synthetic drugs in slimming herbal products, and their threats to people’s health it is necessary to create awareness in this case through public authorities.


Keywords


Obesity, Mass spectroscopy, Slimming products, Adulterants, Liquid chromatography.

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About this article

Title

SCREENING AND CONFIRMATION OF DIFFERENT SYNTHETIC ADULTERANTS IN SLIMMING PRODUCTS

Topics

Pharmacology and Toxicology

Keywords

Obesity, Mass spectroscopy, Slimming products, Adulterants, Liquid chromatography.

DOI

10.22159/ajpcr.2018.v11i2.22516

Date

01-02-2018

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 11 Issue 2 February 2018 Page: 260-264

Print ISSN

0974-2441

Online ISSN

2455-3891

Authors & Affiliations

Sajad Fakhri
Department of Pharmacology and Toxicology, School of Pharmacy, Kermanshah University of Medical Science, Kermanshah, Iran.
Iran, Islamic Republic of

Bahareh Mohammadi
Medical Biology Research Center, Kermanshah University of Medical Science, Kermanshah, Iran.
Iran, Islamic Republic of

Ronak Jalili
Medical Biology Research Center, Kermanshah University of Medical Science, Kermanshah, Iran.
Iran, Islamic Republic of

Marziyeh Hajialyani
Pharmaceutical Sciences Research Center, Kermanshah University of Medical Science, Kermanshah, Iran.
Iran, Islamic Republic of

Gholamreza Bahrami
Medical Biology Research Center, Kermanshah University of Medical Science, Kermanshah, Iran.
Iran, Islamic Republic of


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