COST-EFFECTIVENESS OF HLA-B*5701 PROSPECTIVE GENETIC SCREENING OF HYPERSENSITIVITY TO ABACAVIR


Kubaeva M B, Gushchina J Sh, Loskutova E E

Abstract


  Objective: This study was conducted to evaluate the use of genetic tests, before prescribing drugs to reduce not only the level of side effects but also the costs associated with changing therapy. In this paper, the authors analyze the economic efficiency of HLA*5701 prospective screening of hypersensitivity to abacavir (ABC) in the treatment of HIV-infected patients.

Methods: A retrospective study was conducted among HIV-infected patients taking first-line antiretroviral therapy and further, based on the results obtained with the ABC-hypersensitivity reactions, analyzed the costs that affect on healthcare system.

Results: In the study group of HIV-infected patients, most of the cases belonged to a young, socially active part of the population. Among the study population of patients (n=637), 171 patients were assigned ABC-containing antiretroviral therapy. An increase in costs was found in 67% of cases when ABC-containing first-line therapy was replaced due to the occurrence of undesirable reactions.

Conclusion: The results show that, using this screening, we could reduce the costs associated with replacement therapy


Keywords


HIV, Abacavir, HLA*5701 prospective screening, economic efficiency

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References


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About this article

Title

COST-EFFECTIVENESS OF HLA-B*5701 PROSPECTIVE GENETIC SCREENING OF HYPERSENSITIVITY TO ABACAVIR

Keywords

HIV, Abacavir, HLA*5701 prospective screening, economic efficiency

DOI

10.22159/ajpcr.2018.v11i2.22519

Date

01-02-2018

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 11 Issue 2 February 2018 Page: 281-283

Print ISSN

0974-2441

Online ISSN

2455-3891

Authors & Affiliations

Kubaeva M B
Department of General and Clinical Pharmacology, Medical Institute, Peoples’ Friendship University, Moscow, Russian Federation, Russian.
Russian Federation

Gushchina J Sh
Department of General and Clinical Pharmacology, Medical Institute, Peoples’ Friendship University, Moscow, Russian Federation, Russian.
Russian Federation

Loskutova E E
2Department of Management and Economics of Pharmacy, Medical Institute Peoples’ Friendship University, Moscow, Russian Federation, Russian.
Russian Federation


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