YELLOWNESS IS A THREAT TO NEWBORN - A REVIEW
Keywords:Neonatal jaundice, Hyperbilirubinemia, Kernicterus, Glucuronosyltransferase, Biliverdin, Cephalohematoma, Phototherapy
Â Jaundice is a very well-known disease found worldwide. Jaundice comes from the French word Jauneâ€ - which means yellow. In medical term, jaundice is known as icterus which is a Greek word. This is a very common disease in the population, which causes the yellowish or greenish pigmentation in the skin and whiteness in the eyes. This is a condition of hyperbilirubinemia in which the amount of bilirubin increases in the blood. In this case, the high amount of bilirubin is found in blood, and the disruption of the movement of bilirubin into the liver and out of the body causes jaundice. Different symptoms seen in this case are yellow skin, yellow/white eyes, dark or reddish urine, loss of appetite, bitter taste of tongue, pale faces, nausea, itching in skin, anfd slow pulse rate. Jaundice may be mild to severe. Different types of jaundice are seen like normal jaundice in newborn, hepatic jaundice, and post-hepatic Jaundice.
Amin SB. Clinical assessment of bilirubin-induced neurotoxicity in premature infants. Semin Perinatol 2004;28:340-7.
Amin SB, Charafeddine L, Guillet R. Transient bilirubin encephalopathy and apnea of prematurity in 28 to 32 weeks gestational age infants. J Perinatol 2005;25:386-90.
Tali SH, Yousuf S, Hussain I. Clinical profile and outcome of neonates admitted to a secondary intensive care unit in north India. Asian J Pharm Clin Res 2017;10:339-40.
Abdullah UY, Jassim HM, Baig AA, Khorsheed RM, Al-Khayat AM, Hishamshah M, et al. Gallstones in patient with inherited hemolytic disease. Hematology Am Soc Hematol Educ Program 2015;2015:392 9.
Graziani LJ, Mitchell DG, Kornhauser M, Pidcock FS, Merton DA, Stanley C, et al. Neurodevelopment of preterm infants: Neonatal neurosonographic and serum bilirubin studies. Pediatrics 1992;89:229-34.
van de Bor M, Ens-Dokkum M, Schreuder AM, Veen S, Brand R, Verloove-Vanhorick SP, et al. Hyperbilirubinemia in low birth weight infants and outcome at 5 years of age. Pediatrics 1992;89:359-64.
Ip S, Chung M, Kulig J, Oâ€™Brien R, Sege R, Glicken S, et al. An evidence-based review of important issues concerning neonatal hyperbilirubinemia. Pediatrics 2004;114:e130-53.
Newman TB, Klebanoff MA. Neonatal hyperbilirubinemia and long-term outcome: Another look at the collaborative perinatal project. Pediatrics 1993;92:651-7.
Scheidt PC, Graubard BI, Nelson KB, Hirtz DG, Hoffman HJ, Gartner LM, et al. Intelligence at six years in relation to neonatal bilirubin levels: Follow-up of the national institute of child health and human development clinical trial of phototherapy. Pediatrics 1991;87:797-805.
Wennberg RP, Ahlfors CE, Bhutani VK, Johnson LH, Shapiro SM. Toward understanding kernicterus: A challenge to improve the management of jaundiced newborns. Pediatrics 2006;117:474-85.
Bratlid D. How bilirubin gets into the brain. Clin Perinatol 1990;17:449-65.
Wennberg RP, Ahlfors CE, Rasmussen LF. The pathochemistry of kernicterus. Early Hum Dev 1979;3:353-72.
Ahlfors CE, Amin SB, Parker AE. Unbound bilirubin predicts abnormal automated auditory brainstem response in a diverse newborn population. J Perinatol 2009;29:305-9.
Amin SB, Ahlfors C, Orlando MS, Dalzell LE, Merle KS, Guillet R, et al. Bilirubin and serial auditory brainstem responses in premature infants. Pediatrics 2001;107:664-70.
Nakamura H, Yonetani M, Uetani Y, Funato M, Lee Y. Determination of serum unbound bilirubin for prediction of kernicterus in low birthweight infants. Acta Paediatr Jpn 1992;34:642-7.
Cashore WJ, Oh W. Unbound bilirubin and kernicterus in low-birth-weight infants. Pediatrics 1982;69:481-5.
Funato M, Tamai H, Shimada S, Nakamura H. Vigintiphobia, unbound bilirubin, and auditory brainstem responses. Pediatrics 1994;93:50-3.
Nakamura H, Takada S, Shimabuku R, Matsuo M, Matsuo T, Negishi H, et al. Auditory nerve and brainstem responses in newborn infants with hyperbilirubinemia. Pediatrics 1985;75:703-8.
Zamet P, Nakamura H, Perez-Robles S, Larroche JC, Minkowski A. The use of critical levels of birth weight and free bilirubinâ€ as an approach for prevention of kernicterus. Biol Neonate 1975;26:274-82.
Ostrow JD, Mukerjee P, Tiribelli C. Structure and binding of unconjugated bilirubin: Relevance for physiological and pathophysiological function. J Lipid Res 1994;35:1715-37.
Brodersen R. Bilirubin. Solubility and interaction with albumin and phospholipid. J Biol Chem 1979;254:2364-9.
Shapiro SM. Bilirubin toxicity in the developing nervous system. Pediatr Neurol 2003;29:410-21.
Calligaris SD, Bellarosa C, Giraudi P, Wennberg RP, Ostrow JD, Tiribelli C, et al. Cytotoxicity is predicted by unbound and not total bilirubin concentration. Pediatr Res 2007;62:576-80.
Ruud Hansen TW. Phototherapy for neonatal jaundice-therapeutic effects on more than one level? Semin Perinatol 2010;34:231-4.
Glushko V, Thaler M, Ros M. The fluorescence of bilirubin upon interaction with human erythrocyte ghosts. Biochim Biophys Acta 1982;719:65-73.
Tran CD, Beddard G. Interactions between bilirubin and albumins using picosecond fluorescence and circularly polarized luminescence spectroscopy. J Am Chem Soc 1982;104:6741-7.
Matheson IB, Faini GJ, Lee J. Low-temperature absorption and fluorescence spectra and quantum yields of bilirubin. Photochem Photobiol 1975;21:135-7.
Chen RF. Fluorescence stopped-flow study of relaxation processes in the binding of bilirubin to serum albumins. Arch Biochem Biophys 1974;160:106-12.
Krasner J, Yaffe SJ. FLuorescent properties of the bilirubin-albumin complex. Birth Defects Orig Artic Ser 1976;12:168-74.
Khan MM, Tayyab S. On the modulation of photoinduced fluorescence enhancement and conformational stability of albumin-bound bilirubin: Effect of epsilon-NH(2) groups blocking and chloroform binding. Biochim Biophys Acta 2000;1523:147-53.
Lamola AA, Eisinger J, Blumberg WE, Patel SC, Flores J. Flurorometric study of the partition of bilirubin among blood components: Basis for rapid microassays of bilirubin and bilirubin binding capacity in whole blood. Anal Biochem 1979;100:25-42.
Jacobsen J. Binding of bilirubin to human serum albumin-determination of the dissociation constants. FEBS Lett 1969;5:112-4.
Wells R, Hammond K, Lamola AA, Blumberg WE. Relationships of bilirubin binding parameters. Clin Chem 1982;28:432-9.
Jacobsen J. Studies of the affinity of human serum albumin for binding of bilirubin at different temperatures and ionic strength. Int J Pept Protein Res 1977;9:235-9.
Roca L, Calligaris S, Wennberg RP, Ahlfors CE, Malik SG, Ostrow JD, et al. Factors affecting the binding of bilirubin to serum albumins: Validation and application of the peroxidase method. Pediatr Res 2006;60:724-8.
Bratlid D. Reserve albumin binding capacity, salicylate saturation index, and red cell binding of bilirubin in neonatal jaundice. Arch Dis Child 1973;48:393-7.
McDonagh AF, Vreman HJ, Wong RJ, Stevenson DK. Photoisomers: Obfuscating factors in clinical peroxidase measurements of unbound bilirubin? Pediatrics 2009;123:67-76.
Onishi S, Isobe K, Itoh S, Manabe M, Sasaki K, Fukuzaki R, et al. Metabolism of bilirubin and its photoisomers in newborn infants during phototherapy. J Biochem 1986;100:789-95.
Koren R, Nissani E, Perlmutter-Hayman B. The kinetics of the reaction between bovine serum albumin and bilirubin. A second look. Biochim Biophys Acta 1982;703:42-8.
Ash KO, Holmer M, Johnson CS. Bilirubin-protein interactions monitored by difference spectroscopy. Clin Chem 1978;24:1491-6.
Hertz H. Available bilirubin binding sites of serum from newborns determined by a direct spectrometric method using bromphenol blue. Scand J Clin Lab Invest 1975;35:561-8.
Lee K, Gartner LM, Zarafu I. Fluorescent dye method for determination of the bilirubin-binding capacity of serum albumin. J Pediatr 1975;86:280-5.
Cashore WJ, Monin PJ, Oh W. Serum bilirubin binding capacity and free bilirubin concentration: A comparison between sephadex G-25 filtration and peroxidase oxidation techniques. Pediatr Res 1978;12:195-8.
Priolisi A, Ziino L. Comparative analysis between the reserve albumin-binding capacity (HBABA method) and the saturation index of hyperbilirubinemic sera. Biol Neonate 1971;19:258-71.
Priolisi A. Gel filtration of hyperbilirubinemic sera through sephadex G-25 and sephadex LH-20 for the detection of â€˜freeâ€™ non-albumin-bound unconjugated bilirubin. Biol Neonate 1977;31:103-10.
Berde CB, Benitz WE, Rasmussen LF, Kerner JA, Johnson JD, Wennberg RP, et al. Bilirubin binding in the plasma of newborns: Critical evaluation of a fluorescence quenching method and comparison to the peroxidase method. Pediatr Res 1984;18:349-54.
Levine RL. Fluorescence-quenching studies of the binding of bilirubin to albumin. Clin Chem 1977;23:2292-301.
Lee KS, Gartner LM, Vaisman SL. Measurement of bilirubin-albumin binding. I. Comparative analysis of four methods and four human serum albumin preparations. Pediatr Res 1978;12:301-7.
Krakaur RB, Scanlon JW. Detection of free bilirubin and estimation of reserve albumin binding capacity. Clin Lab Med 1981;1:329-43.
Burckart GJ, Whitington PF, Gross SR. Reserve bilirubin binding capacity determined by difference spectroscopy. I. Modifications and performance of the difference spectroscopy assay. J Pediatr Gastroenterol Nutr 1982;1:489-93.
Seem E, Wille L. Salicylate saturation index in neonatal jaundice. Biol Neonate 1975;26:67-75.
Porter EG. A rapid micromethod for measuring the reserve albumin-binding capacity in serum from newborn infants with hyperbilirubinemia. J Lab Clin Med 1966;67:660-8.
Wells R, Drew JH, Hammond KB. Bilirubin binding capacity and free bilirubin concentration: Fluorescence quenching compared with peroxidase oxidation and sephadex column elution techniques. Clin Chim Acta 1981;116:69-79.
Brown AK, Eisinger J, Blumberg WE, Flores J, Boyle G, Lamola AA, et al. A rapid fluorometric method for determining bilirubin levels and binding in the blood of neonates: Comparisons with a diazo method and with 2-(4â€™-hydroxybenzene)azobenzoic acid dye binding. Pediatrics 1980;65:767-76.
Cashore WJ, Oh W, Blumberg WE, Eisinger J, Lamola AA. Rapid fluorometric assay of bilirubin and bilirubin binding capacity in blood of jaundiced neonates: Comparisons with other methods. Pediatrics 1980;66:411-6.
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