POTENCY OF CHIVES (ALLIUM SCHOENOPRASUM L.) LEAVES INFUSE AS INHIBITOR CALCIUM LITHOGENESIS ON URINARY TRACT
Keywords:Chives, Calcium oxalate, Lithogenesis, Infuse, Urinary
Â Objective: This study examined the antilithogenesis activity by in vitro and histopathologic study from the infuse solution of chives leaves powder.
Methods: The study begins with standard phytochemical screening on the powder of chives leaves. For performing in vitro antilithogenesis activity, atomic absorption spectrophotometry method was adopted to measure the dissolved calcium level. Histopathologic study was using animal models.
Result: Phytochemical screening of chives leaves powder has a lot of phytochemical constituents. In vitro assay showed that chives infuse can dissolve the human calcium stone (47.7% for 12.5% concentration of chives leaves infuse). The histopathologic study showed that chives leaves can be used to treat the calcium lithogenesis.
Conclusion: This experiment provides evidence that chives leaves have highlighted the potential efficacy for the treatment of calcium lithogenesis.
Sodimbaku V, Pujari L. Urolithiasis-an updated reviewe over genetics, pathophysiology and its cliical management. Int J Pham Pham Sci 2014;6:23-31.
Suryavanshi MV, Jadha SD, Gune RP, Bhatia MS, Shouche YS. HPLC analysis of human urine for oxalate content. Int J Pham Pham Sci 2016;8:54-9.
Ramesh K, Manohar S, Rajeskumar S. Nephroprotective activity of ethanolic extract of Orthosiphon stamineus leaves on ethylene glycol induced urolithiasis in albino rats. Int J PharmTech Res 2014;6:403-8.
Winston D. Herbal and nutritional treatment of kidney stones. J Am Herbalists Guild 2011;10:61-9.
Saha S, Ramtej JV. Bergenia ciliata extract prevent ethylene glycol induced histopathological changes in the kidney. Acta Pol Pharm Drug Res 2010;68:711-5.
Taylor CS, Goyal A. Isolation of phytoconstituents and in vitro anthilithiatic by titrimetic method, antioxidant activity by 1,1-diphenyl-2-picryl hydraziyl scavenging assay method of alcoholic roots and rhizomes extract of Hedychium coronarium J Koenig Plant species. Asian J Pharm Clin Res 2015;8:225-9.
Hadjzadeh MA, Mohammadian N, Rahmani Z, Rassouli FB. Effect of thymoquinone on ethylene glycol-induced kidney calculi in rats. Urol J 2008;5:149-55.
Iksen. The Effect of Chives (Allium schoenoprasum, L.) Leaves Infuse on the Calcium Salt Solubility Using in vitro and in vivo by Atomic Absorption Spectrophotometry. Thesis 2017, Faculty of Pharmacy, University of Sumatera Utara: 1-72.
Al-Snafi AE. Pharmacological effects of allium species grown in Iraq. Int J Pharm Health Care Res 2014;1:132-55.
Amalia L, Sukandar EY, Roesli RM, Sigit JI. The effect of ethanol extract of kucai (Allium schoenoprasum L.) bulbs on serum nitric oxide level in male wistar rats. Int J Pharm 2008;4:487-93.
Jalkumar B, Jasmine R. A review of a few medicinal plants possessing anticancer activity against human breast cancer. Int J PharmTech Res 2016;9:333-65.
Parvu AE, Parvu M, Vlase L, Miclea P, Mot AC, Dumitrescu RS. Anti-inflammatory effects of Allium schoenoprasum L. leaves. J Physiol Pharmacol 2014;65:309-15.
Sachinm UR, Priyanka RP, Sagar RM. Use of natural antioxidants to scavenge free radicals: A major cause of diseases. Int J PharmTech Res 2010;2:1074-81.
Haro G, Sinaga SM, Iksen I, Nerdy N, Theerachetmongkol S. Protective effects of chives leaves (Allium schoenoprasum L) infusion against ethylene glycol and ammonium chloride induced nephrolithiasis in rats. J Appl Pharm Sci 2017;7:222-5.
Iksen I, Haro G, Sinaga SM. In vitro test of chive leaves infuse (Allium schoenoprasum, L) on calcium oxalate solubility using atomic absorption specthrophotometry. Int J ChemTech Res 2017;10:99-2.
Indonesiaâ€™s Ministry of Health. Indonesia Pharmacopoeia. 4th ed. Jakarta: Indonesiaâ€™s Ministry of Health;
Depkes RI. Materia Medika. Vol. 6. Indones: Ditjen POM; 1995. p. 297-307.
Farnsworth NR. Biologycal and phytochemical screening of plants. J Pharm Sci 1996;55:225-76.
Harbone JB. Metode Fitokimia. Vol. 2. Bandung: ITB 1987. p. 49.
Velpandian V, Rajaprehidha SS, Banumathi V, Anbu J, Anjana A. Effect of vediyuppu cheyaneer in ethylene glycol induced hyperoxaluria model in rats. Int J Life Sci Pharm Res 2012;2:63-7.
Shekha MS, Ismail TF, Aziz FM. Anti-urolithiatic and anti-oxidant effects of fenugreek on ethylene glycol-induced kidney calculi in rats. Jordan J Biol Sci 2015;8:159-63.
Deepika A, Minu S, Singla SK. The role of natural antioxidants as potential therapeutic agent in nephrolithiasis. Asian J Pharm Clin Res 2013;6:48-53.
Lee HJ, Jeong SJ, Park MN, Linnes M, Han HJ, Kim JH, et al. Gallotannin suppresses calcium oxalate crystal binding and oxalate-induced oxidative stress in renal epithelial cells. Biol Pharm Bull 2012;35:539-44.
Antunes LM, Darin JD, Nde LB. Effects of the antioxidants curcumin or selenium on cisplatin-induced nephrotoxicity and lipid peroxidation in rats. Pharmacol Res 2001;43:145-50.
Sudhahar V, Veena CK, Varalakshmi P. Antiurolithic effect of lupeol and lupeol linoleate in experimental hyperoxaluria. J Nat Prod 2008;71:1509-12.
How to Cite
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.