THE EFFECT OF COPROCESSED SUPERDISINTEGRANTS RATIO (CROSPOVIDONE-SODIUM STARCH GLYCOLATE) TO THE PHYSICOCHEMICAL CHARACTERISTICS OF ATENOLOL ORALLY DISINTEGRATING TABLETS

Nani Parfati; Karina Citra Rani; Meilany Meilany

doi:10.22159/ajpcr.2018.v11i2.23010

Authors

Nani Parfati Department of Pharmaceutics, UBAYA College of Pharmacy, University of Surabaya, Kalirungkut, Surabaya 60293, East Java, Indonesia
Karina Citra Rani Department of Pharmaceutics, UBAYA College of Pharmacy, University of Surabaya, Kalirungkut, Surabaya 60293, East Java, Indonesia http://orcid.org/0000-0003-2421-5754
Meilany Meilany Department of Pharmaceutics, UBAYA College of Pharmacy, University of Surabaya, Kalirungkut, Surabaya 60293, East Java, Indonesia

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i2.23010

Keywords:

Coprocessed, Superdisintegrants, Atenolol, Orally disintegrating tablets

Abstract

Â Objective: The objective of this study was to evaluate the effect of coprocessed superdisintegrants (crospovidone-sodium starch glycolate) ratio 1:1; 1:2; and 1:3 to the physicochemical characteristics of atenolol orally disintegrating tablets.

Methods: Orally disintegrating tablets of atenolol were prepared by direct compression method. There were three formulas which using three different ratios of coprocessed superdisintegrants (crospovidone-sodium starch glycolate). The ratio of coprocessed superdisintegrants were, 1:1 (formula 1); 1:2 (formula 2); and 1:3 (formula 3). Evaluation of the formulas was conducted before compression (pre-compression evaluation) and after compression (post-compression evaluation).

Results: The results of pre-compression evaluation showed that all the formulas have good flowability and excellent angle of repose. The results of post-compression evaluation showed that all the formulas met the specification of orally disintegrating tablets. The different ratio of coprocessed crospovidone-sodium starch glycolate (1:1; 1:2; and 1:3) caused significant differences in tablet dispersion time (p<0.05). Dissolution test showed that all the formulas met the specification of dissolution from atenolol tablet (not <85% of atenolol was dissolved in 30 min). Formula 1 showed the highest dissolution efficiency (92.91Â±0.11)% and area under the curve value (11149.13Â±13.15) compared to formula 2 and formula 3.

Conclusion: The results from this study showed that coprocessed superdisintegrants (crospovidone-sodium starch glycolate) ratio affect the physicochemical characteristics of atenolol orally disintegrating tablet. Based on pre-compression evaluation and post-compression evaluation, formula 1 was the best formula.

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Author Biographies

Nani Parfati, Department of Pharmaceutics, UBAYA College of Pharmacy, University of Surabaya, Kalirungkut, Surabaya 60293, East Java, Indonesia

Lecturer

Karina Citra Rani, Department of Pharmaceutics, UBAYA College of Pharmacy, University of Surabaya, Kalirungkut, Surabaya 60293, East Java, Indonesia

Lecturer, Departement of Pharmaceutics, UBAYA College of Pharmacy, University of Surabaya

Meilany Meilany, Department of Pharmaceutics, UBAYA College of Pharmacy, University of Surabaya, Kalirungkut, Surabaya 60293, East Java, Indonesia

Student in UBAYA College of Pharmacy, University of Surabaya

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