ANGIOTENSIN I-CONVERTING ENZYME INHIBITORY ACTIVITY, TOTAL PHENOLIC AND FLAVONOID CONTENT OF EXTRACT AND FRACTION OF JAM FRUIT LEAVES (MUNTINGIA CALABURA L.)


Eka Lasboi, Rissyelly Rissyelly, Katrin Katrin

Abstract


 

Objective: Hypertension is one of the most common chronic diseases. Inhibitory activity of angiotensin I-converting enzyme (ACE) is effective on giving hypotensive effect. Jamfruit leaf (Muntingia calabura L.) was reported to have an excellent hypotensive effect. This research was aimed to test in the manner of in vitro the inhibitory activity of ACE.

Methods: This research used ACE kit-WST, total phenolic content, and total flavonoid from jam fruit leaf ethanol extract, hexane, ethyl acetate, and butanol fraction.

Results: The result showed that Jamfruit leaf extract had ACE inhibitory activity and the most active fraction was ethyl acetate fraction. Inhibitory concentration 50% value of the most active fraction, ethyl acetate fraction was 0.63 μg/mL. Ethyl acetate fraction also provides most flavonoid and phenolic content with a value of 10.91 mg/g extract quercetin equivalent and 74.90 mg/g extract gallic acid equivalent.

Conclusions: Ethyl acetate fraction of jam fruit leaf had most flavonoid, phenolic compound, and ACE inhibitory activity.


Keywords


Muntingia calabura, Angiotensin I-converting enzyme inhibition, Antihypertensive, Phenolic, Flavonoid.

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About this article

Title

ANGIOTENSIN I-CONVERTING ENZYME INHIBITORY ACTIVITY, TOTAL PHENOLIC AND FLAVONOID CONTENT OF EXTRACT AND FRACTION OF JAM FRUIT LEAVES (MUNTINGIA CALABURA L.)

Keywords

Muntingia calabura, Angiotensin I-converting enzyme inhibition, Antihypertensive, Phenolic, Flavonoid.

DOI

10.22159/ajpcr.2017.v10s5.23123

Date

01-10-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol. 10, Special Issue (Oct.), 2017 [PTMDS 2017] Page: 166-168

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

81 Views | 15 Downloads

Authors & Affiliations

Eka Lasboi
Department of , Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
Indonesia

Rissyelly Rissyelly
Department of , Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
Indonesia

Katrin Katrin
Department of , Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
Indonesia


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