FORMULATION OF TABLET FROM PAPAYA AND BAY LEAF EXTRACT WITH VARIATION OF CONCENTRATION POLYVINYLPYRROLIDONE AS A BINDER


Erni Rustiani, Mira Miranti, Nurul Karima Rahmahuda

Abstract


 

Objectives: Extensive studies on the pharmacological activities of papaya and bay leaf exhibit that these plants effectively alleviate degenerative diseases including diabetes. However, herbal drugs from papaya and bay leaf have never been made. The aim of this research was to formulate a tablet from the combination of papaya extract and bay leaf with different concentrations (1%, 2%, and 3%) of polyvinylpyrrolidone (PVP) K30 as a binder using the wet granulation method.

Methods: Evaluation of the tablet’s physical properties (i.e., weight variation, friability, hardness, disintegration time, and physical appearance) was done using standard methods while total flavonoid in the extracts was determined by the spectrophotometry method.

Results: The tablet was light brown and had both flat top and bottom, a specific odor and a bitter taste. The physical properties of the tablet were in accordance with pharmaceutical standards. The total flavonoid content in the papaya and bay leaves extract was 1.562% and 2.240%, respectively.

Conclusions: It can be concluded that PVP K-30 concentration can be used as a binder to formulate dry papaya and bay leaf extracts into high-quality and ready-to-consume tablets.


Keywords


Papaya leaf extract, Bay leaf extract, Tablets, Polyvinylpyrrolidone K30, Flavonoid.

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References


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About this article

Title

FORMULATION OF TABLET FROM PAPAYA AND BAY LEAF EXTRACT WITH VARIATION OF CONCENTRATION POLYVINYLPYRROLIDONE AS A BINDER

Keywords

Papaya leaf extract, Bay leaf extract, Tablets, Polyvinylpyrrolidone K30, Flavonoid.

DOI

10.22159/ajpcr.2017.v10s5.23124

Date

01-10-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Special Issue October 2017 [PTMDS 2017] Page: 169-173

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

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Authors & Affiliations

Erni Rustiani
Department of Pharmacy, Pakuan University, Bogor, Indonesia.
Indonesia

Mira Miranti
Department of Pharmacy, Pakuan University, Bogor, Indonesia.
Indonesia

Nurul Karima Rahmahuda
Department of Pharmacy, Pakuan University, Bogor, Indonesia.
Indonesia


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