RECENT APPROACHES OF SOLID DISPERSION: A NEW CONCEPT TOWARD ORAL BIOAVAILABILITY .


Sabitri Bindhani, Snehamayee Mohapatra

Abstract


 Solid dispersion (SD) has been a major advanced technology in overcoming dissolution and bioavailability problem of poorly soluble compounds. Formulation of SD in water-soluble carrier has becoming more researched over the past four decades for solubility and relative bioavailability enhancement. By reduction of the size of the drug particle to the minimum level which will enhance drug wettability and ultimately bioavailability will be definitely improved. This review article elaborates recent advanced technology and characterization of SDs and also discusses the problems and their solution for the development of better formulations.


Keywords


Solid dispersion, Poorly water-soluble drug, Problems and solution, Preparation and characterization, Future perspective and strategies

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References


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About this article

Title

RECENT APPROACHES OF SOLID DISPERSION: A NEW CONCEPT TOWARD ORAL BIOAVAILABILITY .

Topics

pharmacy;pharmaceutics

Keywords

Solid dispersion, Poorly water-soluble drug, Problems and solution, Preparation and characterization, Future perspective and strategies

DOI

10.22159/ajpcr.2018.v11i2.23161

Date

01-02-2018

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 11 Issue 2 February 2018 Page: 72-78

Print ISSN

0974-2441

Online ISSN

2455-3891

Authors & Affiliations

Sabitri Bindhani
Department of pharmaceutics, Faculty of School of Pharmaceutical Sciences Siksha “O” Anusandhan University, Khandagiri, Bhubaneswar - 751 030, Odisha, India
India

Snehamayee Mohapatra
Department of pharmaceutics, Faculty of School of Pharmaceutical Sciences Siksha “O” Anusandhan University, Khandagiri, Bhubaneswar - 751 030, Odisha, India
India


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