• Wahyudi Department of Pharmacology, Faculty of Pharmacy.Indonesia
  • Edy Suwarso Department of Pharmacology, Faculty of Pharmacy.Indonesia
  • Marline Nainggolan Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.



African leaves, Peptic ulcer, Acetosal, Vernonia amygdalina Del


 Objectives: This study aims to evaluate the anti-ulcer activity of African leaves (Vernonia amygdalina Del.) ethanol extract on male rat.

Methods: African leaf powder was extracted used ethanol 96% by percolation, then made into a suspension preparation used 0.5% Na-CMC with 3 dose variations (100, 200 and 400 mg/kg). Further tested its effectiveness in healing peptic ulcer in gastric-induced rats using acetosal dose 800 mg/kg with oral administration every day until surgery at 3, 8, and 14. Observations include macroscopic (number and index of ulcer) and microscopic (histopathological test).

Results: A significant healing of ulcer was observed. The extract 100, 200, and 400 mg/kg group showed significant (p<0.05) reduction in number and index of ulcer as compared to the negative control. The most effective dose is 200 mg/kg because it has the greatest ability to reduce the number and index of ulcers and has the fastest recovery day.

Conclusion: Results of this study indicated that African leaves (V. amygdalina Del.) ethanol extract has potential anti-ulcer activity.


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How to Cite

Wahyudi, E. Suwarso, and M. Nainggolan. “ANTI-ULCER ACTIVITY OF AFRICAN LEAVES (VERNONIA AMYGDALINA DEL.) ETHANOL EXTRACT ON MALE RAT”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 3, Mar. 2018, pp. 375-8, doi:10.22159/ajpcr.2018.v11i3.23565.



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