EVALUATION OF IN VITRO ANTIDIABETIC AND ANTIOXIDANT POTENTIAL OF BARLERIA CRISTATA LEAVES EXTRACTS

Sakthivel Vasanth; Giridharan Bupesh; Tharumasivam Siva Vijayakumar; Vellingiri Balachandar; Durai Rajan Gunasekaran

doi:10.22159/ajpcr.2018.v11i4.24069

Authors

Sakthivel Vasanth R and D Wing, Central Research Laboratory, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India.
Giridharan Bupesh R and D Wing, Central Research Laboratory, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India.
Tharumasivam Siva Vijayakumar Department of Biotechnology, Srimad Andavan College of Arts and Science, Tiruchirappalli, Tamil Nadu, India.
Vellingiri Balachandar Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu, India.
Durai Rajan Gunasekaran R and D Wing, Central Research Laboratory, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i4.24069

Keywords:

Barleria cristata, Ethanol extract, Petroleum ether extract, Antidiabetic activity, Antioxidant activity, In vitro study

Abstract

Â Objectives: The objectives of the study were to study the in vitro antidiabetic and antioxidant activity of Barleria cristata leaves extracts.

Methods: Ethanol extract and petroleum ether extract of leaf and root of B. cristata were tested for their antidiabetic activity. The in vitro antidiabetic activity from Î±-amylase, Î±-glucosidase, and antioxidant activity was used to assess the potential activity of the fractions.

Results: Our attempt results suggest that ethanol and the petroleum ether leaf extract from B. cristata show signs of dose-dependent increases to inhibitory activity on Î±-amylase, Î±-glucosidase enzymes, and antioxidant activity when compared with control. Ethanolic leaves to extract produced maximum in vitro antidiabetic effect and antioxidant activity when compared to petroleum ether extract.

Conclusion: The ethanol leaf extract from B. cristata may be used in managing of blood glucose in a medical condition like diabetes.

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