• Alfred Maroyi Department of Botany, Medicinal Plants and Economic Development Research Centre, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa.


Euclea crispa is widely used as herbal medicine in southern Africa. This study was aimed at reviewing the botany, ethnomedicinal uses, and validated pharmacological properties of E. crispa. The literature search for information on ethnomedicinal uses and pharmacological activities of E. crispa was undertaken using databases such as web of science, BMC, science direct, elsevier, scopus, PubMed, and scielo. Other relevant literature sources included books, book chapters, websites, theses, conference papers, and other scientific publications. The extensive literature survey revealed that the bark, fruits, leaves, and roots of E. crispa are commonly used as herbal medicines for wounds, constipation, cough, stomach disorders, epilepsy, rheumatism, and diabetes. Pharmacological studies on E. crispa indicate that the species has amyloid β-peptide lowering effects, antibacterial, antidiarrheal, antifungal, and cell membrane disruption activities. E. crispa should be subjected to further scientific evaluations aimed at elucidating its chemical, pharmacological, and toxicological properties. Such detailed research should also include experimental animal studies, randomized clinical trials, and target-organ toxicity studies involving E. crispa extracts and its derivatives.

Keywords: Euclea crispa, Ethnopharmacology, Indigenous knowledge, Southern Africa, Traditional medicine.


1. Wallnöfer B. The biology and systematics of Ebenaceae: A review. Ann Naturhist Mus Wien 2001;103B:485-512.
2. Duangjai S, Wallnöfer B, Samuel R, Munzinger J, Chase MW. Generic delimitation and relationships in Ebenaceae sensu lato: Evidence from six plastid DNA regions. Am J Bot 2006;93:1808-27.
3. Wiart C. Medicinal Plants of Asia and the Pacific. Boca Raton: CRC Press; 2006.
4. Trease GE, Evans WC. Pharmacognosy. London: Baillière Tindall; 1983.
5. Mallavadhani UV, Panda AK, Rao YR. Pharmacology and chemotaxonomy of diospyros. Phytochemistry 1998;49:901-51.
6. Lim TK. Edible Medicinal and Non-medicinal Plants. Fruits. Vol. 2. London: Springer; 2012.
7. Hutchings A, Scott AH, Lewis G, Cunningham AB. Zulu Medicinal Plants: An Inventory. Pietermaritzburg: University of Natal Press; 1996.
8. Maroyi A. Review of ethnomedicinal uses, phytochemistry and pharmacological properties of Euclea natalensis A.DC. Molecules 2017;22:pii: E2128.
9. Maroyi A. Euclea undulata Thunb.: Review of its botany, ethnomedicinal uses, phytochemistry and biological activities. Asian Pac J Trop Med 2017;10:1030-6.
10. Jacot-Guillarmod A. Flora of Lesotho. Lehre: J Cramer; 1971.
11. Palmer E, Pitman P. Trees for Southern Africa Covering all Known Indigenous Species in Republic of South Africa, South West Africa, Botswana, Lesotho and Swaziland. Cape Town: A.A. Balkema; 1972.
12. Gelfand M, Mavi S, Drummond RB, Ndemera B. The Traditional Medical Practitioner in Zimbabwe: His Principles of Practice and Pharmacopoeia. Gweru: Mambo Press; 1985.
13. Dzerefos CM, Witkowski ET. Density and potential utilization of medicinal grassland plants from Abe bailey nature reserve, South Africa. Biod Cons 2001;10:1875-96.
14. Moteetee A, Van Wyk BE. The medical ethnobotany of Lesotho: A review. Bothalia 2011;41:209-28.
15. Chinsamy M, Koitsiwe M. Traditional knowledge of medicinal and food plant uses for sustainable community livelihoods: A case of Batswana communities in South Africa. J Soc Sci 2016;46:146-54.
16. Dlamini CS, Geldenhuys CJ. The socioeconomic status of the non-timber forest product subsector in Swaziland. Southern For J For Sci 2009;71:311-8.
17. Van Wyk AE, Van Wyk P. Field Guide to Trees of Southern Africa. Cape Town: Struik Publishers (Pty) Ltd.; 1997.
18. Njuguna PM. Euclea divinorum Hiern. In: Jansen PC, Cardon D, editors. Plant Resources of Tropical Africa 3: Dyes and Tannins. Leiden: PROTA Foundation, Backhuys Publishers; 2005. p. 76-9.
19. Liengme CA. Plants used by the Tsonga people of Gazankulu. Bothalia 1981;18:501-8.
20. Moteetee A. A review of plants used for magic by Basotho people in comparison with other cultural groups in southern Africa. Indian J Trad Knowl 2017;16:229-34.
21. Breebaart L. Resource Overlap within a Guild of Browsing Ungulates in a South African Savanna. MSc Dissertation. Pietermaritzburg: University of Natal; 2000.
22. Wiseman R. Woody Vegetation Change in Response to Browsing in Ithala Game reserve, South Africa. MSc Dissertation. Cape Town: University of Cape Town; 2001.
23. Breebaart L, Bhikraj R, O’Connor TG. Dietary overlap between Boer goats and indigenous browsers in a South African savanna. Afr J Range For Sci 2002;19:13-20.
24. Wiseman R, Page BR, O’Connor TG. Woody vegetation change in response to browsing in Ithala Game Reserve, South Africa. S Afr J Wildlife Res 2004;34:25-37.
25. Dludla SP. The Effect of Condensed Tannins on Goats’ Body Weight. MSc Dissertation. Kwadlengezwa: University of Zululand; 2010.
26. Botha J, Weiersbye IM. Ethnobotanic and forage uses of plants on mine properties in the Witwatersrand basin gold fields, South Africa. In: Fourie A, Tibbett M, Wiertz J, editors. Mine Closure. Perth: Australian Centre for Geomechanics; 2010. p. 325-42.
27. Chepape RM, Mbatha KR, Luseba D. Local use and knowledge validation of fodder trees and shrubs browsed by livestock in Bushbuckridge area, South Africa. Livestock Res Rural Dev 2011;23. Available from: [Last accessed on 2017 Feb 24].
28. Maroyi A. The gathering and consumption of wild edible plants in Nhema communal area, midlands province, Zimbabwe. Ecol Food Nutr2011;50:506-25.
29. Fomum SW. Diet Selection and Foraging Efficiency of Nguni Goats in the Bushveld of Gauteng, South Africa. MSc Dissertation. Pietermaritzburg: University of Natal; 2012.
30. Monegi P. Effects of Nutrient-tannin Interactions on Intake and Germination of Woody Plant Species by ruminants. MSc Dissertation. Pretoria: University of South Africa; 2017.
31. Van Wyk BE, Gorelik B. The history and ethnobotany of cape herbal teas. S Afr J Bot 2017;110:18-38.
32. Williams VL, Balkwill K, Witkowski ET. A lexicon of plants traded in the Witwatersrand umuthi shops. Bothalia 2001;31:71-98.
33. Sasi S, Anjum N, Tripathi YC. Ethnomedicinal, phytochemical and pharmacological aspects of Flacourtia jangomas: A review. Int J Pharm Pharm Sci 2018;10:9-15.
34. White F. Ebenaceae. In: Launert E, editor. Flora Zambesiaca. Vol. 7. London: Flora Zambesiaca Managing Committee; 1983. p. 248-300.
35. White F, Verdcourt B. Ebenaceae. In: Polhill RM, editor. Flora of Tropical East Africa. Rotterdam: AA Balkema; 1996. p. 1-53.
36. Palgrave MC. Keith Coates Palgrave trees of southern Africa. 3rd ed. Cape Town: Struik Publishers (Pty) Ltd.; 2002.
37. Mapaura A, Timberlake J. A Checklist of Zimbabwean Vascular Plants. Pretoria: Southern African Botanical Diversity Network Report No. 33, SABONET; 2004.
38. Setshogo MP. Preliminary Checklist of the Plants of Botswana. Pretoria: Southern African Botanical Diversity Network Report No. 33, SABONET; 2005.
39. Germishuizen G, Meyer NL, Steenkamp Y, Keith MA. A Checklist of South African Plants. Pretoria: Southern African Botanical Diversity Network Report No. 41, SABONET; 2006.
40. Stoll A. Euclea crispa (Thunb.) Gürke Subsp. Crispa. Available from: [Last accessed on 2017 Sep 13].
41. Schmidt E, Lotter M, McCleland W. Trees and shrubs of Mpumalanga and Kruger National Park. Johannesburg: Jacana; 2002.
42. Voigt W. Euclea undulata Thunb. Karoo Desert National Botanical Garden; 2013. Available from: [Last accessed on 2017 Jul 13].
43. Tsvuura Z, Nyamhanga E. A preliminary checklist of plants from the Mazowe Botanic Reserve, Zimbabwe. Kirkia 2002;18:49-62.
44. Sibanda S, Mebe PP, Multari G. Pentacyclic triterpenoids from Euclea crispa. Fitoterapia 1992;63:274-7.
45. Masoga MA. Critical reflections on selected local narratives of contextual South African indigenous knowledge. In: Ngulube P, editor. Handbook of Research on Theoretical Perspectives on Indigenous Knowledge Systems in Developing Countries. Hershey PA: IGI Global; 2017. p. 310-31.
46. Long C. Swaziland’s Flora: SiSwati Names and uses. Swaziland National Trust Commission; 2005. Available from: http://www.sntc. [Last accessed on 2017 May 23].
47. Bryant AT. Zulu medicine and Medicine-Men. Cape Town: C. Struik; 1966.
48. Maja L, Masia T, Binyane K, Ramathebane M. Assessment of patient counselling in diabetic and hypertensive patients in terms of patient knowledge about their medication, disease state and lifestyle modifications by pharmacy personnel at LDF clinic in Maseru. Int J Pharm Pharm Sci 2018;10:155-61.
49. Bossard E. La Médecinetraditionnelle au Centre et à L’ouest de L’angola. Lisboa: Ministério da Ciênciae da Tecnologia, Instituto de Investigaçâo Cientifica Tropical; 1996.
50. Schmitz MO. Wild Flowers of Lesotho. Roma: ESSA; 1982.
51. Morris B. Chewa Medical Botany: A Study of Herbalism in Southern Malawi. Hamburg: Lit Verlag; 1996.
52. Fowler DG. Traditional Fever Remedies: Alist of Zambian Plants; 2006. Available from: Fever_remedie1.pdf. [Last accessed on 2017 Sep 13].
53. Vhurumuku E. Knowledge, use and attitudes towards medicinal plants of pre-service teachers at a South African university. Glob Adv Res J Env Sci Toxicol 2015;4:15-24.
54. Semenya SS, Potgieter MJ, Erasmus LJ. Indigenous plant species used by Bapedi healers to treat sexually transmitted infections: Their distribution, harvesting, conservation and threats. S Afr J Bot 2013;87:66-75.
55. Semenya SS, Potgieter MJ, Erasmus LJ. Bapediphytomedicine and their use in the treatment of sexually transmitted infections in Limpopo Province, South Africa. Afr J Pharm Pharmacol 2013;7:250-62.
56. Maroyi A. Alternative medicines for HIV/AIDS in resource-poor settings: Insight from traditional medicines use in sub-Saharan Africa. Trop J Pharm Res 2014;13:1527-36.
57. Tshikalange TE, Mophuting BC, Mahore J, Winterboer S, Lall N. An ethnobotanical study of medicinal plants used in villages under Jongilanga tribal council, Mpumalanga, South Africa. Afr J Tradit Complement Altern Med 2016;13:83-9.
58. Maroyi A, Rasethe MT. Comparative use patterns of plant resources in rural areas of South Africa and Zimbabwe. Phyton Int J Exp Bot 2015;84:288-97.
59. Kokwaro JO. Medicinal plants of East Africa. Nairobi: Kenya Literature Bureau; 1993.
60. Majinda RR, Motswaledi MS. Antibiotic activity of selected Botswana medicinal plants. Botsw Notes Rec 1998;30:157-61.
61. Bandeira SO, Gaspar F, Pagula FP. African ethnobotany and healthcare: Emphasis on Mozambique. Pharm Biol 2001;39 Suppl 1:70-3.
62. Moshi MJ, Mbwambo ZH, Nondo RS, Masimba PJ, Kamuhabwa A, Kapingu MC, et al. Evaluation of ethnomedical claims and brine shrimp toxicity of some plants used in Tanzania as traditional medicines. Afr J Trad Complem Altern Med 2006;3:48-58.
63. More G, Tshikalange TE, Lall N, Botha F, Meyer JJ. Antimicrobial activity of medicinal plants against oral microorganisms. J Ethnopharmacol 2008;119:473-7.
64. Mbanga J, Ncube M, Magumura A. Antimicrobial activity of Euclea undulata, Euclea divinorum and diospyroslycioides extracts on multidrug resistant Streptococcus mutans. J Med Pl Res 2013;7:2741-6.
65. Motlhanka DM, Nthoiwa GP. Ethnobotanical survey of medicinal plants of Tswapong North, in eastern Botswana: A case of plants from Mosweu and Seolwane villages. Eur J Med Pl 2013;3:10-24.
66. Chauke MA, Shai LJ, Mogale MA, Tshisikhawe MP, Mokgotho MP. Medicinal plant use of villagers in the Mopani district, Limpopo province, South Africa. Afr J Trad Complem Altern Med 2015;12:9-26.
67. Ngarivhume T, Van’tKlooster CI, De Jong JT, Westhuizen JH. Medicinal plants used by traditional healers for the treatment of malaria in the Chipinge district in Zimbabwe. J Ethnopharmacol 2015;159:224-37.
68. Posthouwer C. Medicinal Plants of Kariakoomarket, Dar es Salaam, Tanzania. MSc Dissertation. Leiden: Leiden University; 2015.
69. Maroyi A. An ethnobotanical survey of medicinal plants used by the people in Nhema communal area, Zimbabwe. J Ethnopharmacol 2011;136:347-54.
70. Maroyi A. Traditional use of medicinal plants in south-central Zimbabwe: Review and perspectives. J Ethnobiol Ethnomed 2013;9:31.
71. Steenkamp V. Traditional herbal remedies used by South African women for gynaecological complaints. J Ethnopharmacol 2003;86:97-108.
72. Van Wyk BE, Gericke N. People’s Plants: Aguide to Useful Plants of Southern Africa. Pretoria: Briza Publications; 2000.
73. Graham JG, Quinn ML, Fabricant DS, Farnsworth NR. Plants used against cancer: An extension of the work of Jonathan Hartwell. J Ethnopharmacol 2000;73:347-77.
74. Grace OM, Prendergast HD, Jäger AK, Van Staden J. Bark medicines in traditional healthcare in KwaZulu-Natal, South Africa: An inventory. S Afr J Bot 2002;69:301-63.
75. Deutschländer MS, Lall N, Van de Venter M, Dewanjee S. The hypoglycemic activity of Euclea undulata Thunb. Var. Myrtina (Ebenaceae) root bark evaluated in a streptozotocin-nicotinamide induced Type 2 diabetes rat model. S Afr J Bot 2012;80:9-12.
76. Kwon HC, Cha JW, Park JS, Chun YS, Moodley N, Maharaj VJ, et al. Rapid identification of bioactive compounds reducing the production of Amyloid β-Peptide (Aβ) from South African plants using an automated HPLC/SPE/HPLC coupling system. Biomol Ther 2011;19:90-6.
77. España J, Valero J, Miñano-Molina AJ, Masgrau R, Martín E, Guardia-Laguarta C, et al. β-amyloid disrupts activity-dependent gene transcription required for memory through the CREB coactivator CRTC1. J Neurosci 2010;30:9402-10.
78. Pretorius PC, Magama S, Zietsman PC. Growth inhibition of plant pathogenic bacteria and fungi by extracts from selected South African plant species. S Afr J Bot 2003;69:186-92.
79. Pretorius PC, Magama S, Zietsman PC. Purification and identification of antibacterial compounds from Euclea crispa subsp. Crispa (Ebenaceae) leaves. S Afr J Bot 2003;69:579-86.
80. Magama S, Pretorius JC, Zietsman PC. Antimicrobial properties of extracts from Euclea crispa subsp. Crispa (Ebenaceae) towards human pathogens. S Afr J Bot 2003;69:193-8.
81. Alayande KA, Pohl CH, Ashafa AO. Time-kill kinetics and biocidal effect of Euclea crispa leaf extracts against microbial membrane. Asian Pac J Trop Med 2017;10:390-9.
82. Alayande KA, Pohl CH, Ashafa AO. Assessment of anti-diarrhoea properties of Euclea crispa (Thunb.) leaf extract and fractions. S Afr J Bot 2016;103:306.
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How to Cite
Maroyi, A. “EUCLEA CRISPA: REVIEW OF ITS BOTANY, ETHNOMEDICINAL USES, AND PHARMACOLOGICAL PROPERTIES”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, no. 10, Oct. 2018, pp. 5-9, doi:10.22159/ajpcr.2018.v11i10.25146.
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