• Mukesh Shinde
  • Vikram Gharge
  • Shrikant Pimple
  • Mukund Gurjar
  • Mahesh Shah



 Objective: The objective of this study was to compare and evaluate in vitro ex vivo transdermal potential of the diclofenac sodium (DS) gel by different permeation enhancers using Franz-type diffusion cells.

Methods: DS gel was prepared with carbapol, dimethyl sulfoxide, oleic acid (OA), and menthol with 1% w/w concentration each as the penetration enhancer. The in vitro, ex vivo permeability were determined using cellophane membrane and abdominal rat skin. Steady-state flux, permeability coefficient (kp), diffusion coefficient, and lag time were calculated.

Results: Menthol, at the concentration of 1% w/w, shows maximum kp, diffusion coefficient permeation enhancement effect with an enhancement ratio 40%, as compared to dimethyl sulfoxide and OA.

Conclusion: This finding predicts that DS gel 1% w/w containing menthol 1% w/w can possibly deliver therapeutically relevant dose of DS.

Keywords: Diclofenac sodium gel, Menthol, Penetration enhancer, Permeation coefficient.




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How to Cite

Shinde, M., V. Gharge, S. Pimple, M. Gurjar, and M. Shah. “EFFECT OF PENETRATION ENHANCER ON THE IN VITRO EX VIVO PERMEATION OF DICLOFENAC GEL”. Asian Journal of Pharmaceutical and Clinical Research, vol. 7, no. 5, Nov. 2014, pp. 255-9, https://innovareacademics.in/journals/index.php/ajpcr/article/view/2605.



Original Article(s)