FORMULATION AND EVALUATION OF CEFIXIME TRIHYDRATE TOPICAL GEL FOR WOUND INFECTIONS

  • Uma Shankar Marakanam Srinivasan Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur - 603 202, Kanchipuram, Tamil Nadu, India.
  • Vishnu Vishnu Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur - 603 202, Kanchipuram, Tamil Nadu, India.
  • Sharmila Sharmila Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur - 603 202, Kanchipuram, Tamil Nadu, India.
  • Amod Kumar Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur - 603 202, Kanchipuram, Tamil Nadu, India.

Abstract

Objective: The objective of this research work was to formulate and evaluate topical gel loaded with cefixime trihydrate, a third-generation cephalosporin antibiotic for the treatment of bacterial wound infections.

Methods: The cefixime trihydrate gel was formulated using polymers such as Carbopol 940 and hydroxypropyl methylcellulose E4M in varying concentrations. Three different formulations were prepared and characterized physically for color, syneresis, spreadability, pH, drug content, and rheological properties. In vitro drug release in phosphate buffer pH 7.4 and antibacterial study were performed for the gel formulation to evaluate its therapeutic effect on wound infections.

Results: The study demonstrated that the gel formulations showed promising results on their physical evaluation tests. The rheology behavior of the gel was shear-thinning flow type which indicated easy spreading of the gel. The drug release of the gel formulation F2 was selected as the best due to its highest drug release rate of 32.2% in comparison with the other two formulations after 2 h of the study. F2 formulation possessed the highest antibacterial activity as compared to other two formulations.

Conclusion: A pioneering work was done on formulating cefixime trihydrate as a gel for topical administration. The antibacterial effect of the drug as gel formulation showed promising effect. We conclude that the cefixime trihydrate could be successively loaded into a gel formulation and can be used for effectively for wound infections like diabetic foot wounds.

Keywords: Cefixime trihydrate, Antibiotic gel, Wound infection, Diabetic foot wounds.

References

1. Ramachandani U. Formulations and evaluation of topical gel of ketoprofen using different polymers. Inter J Pharm Bioarch 2013;2:323-6.
2. Thomas SK, George RE, Kunjumon M, Thankamani V. In vitro antibacterial profile of Alstonia venenata R. BR-a comparative study. Int J Curr Pharm Res 2015;7:86-8.
3. Alaayed M, Mahmood H, Saeed A. The enhancement effect of castor oil on the permeability of flurbiprofen as Transdermal gel. Int J Appl Pharm 2018;10:140-4.
4. Nanda S, Saroha KA, Sharma BE. Formulation, evaluation and optimization of transdermal gel of ketorolac tromethamine using face centered central composite design. Int J Pharm Pharm Sci 2014;4:133-9.
5. Usama FA. Preparation and evaluation of novel topical gel preparation for wound healing in diabetics. Int J Pharm Pharm Sci 2012;4:76-8.
6. Helal DA, El-Rhman DA, Abdel-Halim SA, El-Nabarawi MA. Formulation and evaluation of fluconazole topical gel. Int J Pharm Pharm Sci 2012;5:176-83.
7. Toppo FA, Pawar RS. Novel drug delivery strategies and approaches for wound healing managements. J Crit Rev 2015;2:12-20.
8. Vats A, Sharma P. Formulation and evaluation of topical anti-acne formulation of coriander oil. Int J Pharm Pharm Sci Res 2012;2:61-6.
9. Agnihotri S, Wakode S, Agnihotri A. Formulation and evaluation of herbal anti-acne gel of Myrica esculenta. Asian J Pharm Clin Res 2016;4:358-61.
10. Harahap NI, Nainggolan M, Harahap U. Formulation and evaluation of herbal antibacterial gel containing ethanolic extract of Mikania micrantha kunth leaves. Asian J Pharm Clin Res 2018;3:429-31.
11. Vasanth S, Bupesh G, Vijayakumar TS, Balachandar V, Gunasekaran D. Evaluation of in vitro anti diabetic and antioxidant potential of Barleria cristata leaves extracts. Asian J Pharm Clin Res 2018;4:287-90.
12. Reza MI, Goel D, Gupta RK, Warsi MH. Formulation of ketoconazole loaded nano dispersive gel using swollen micelles technique and it’s in vitro characterization. Inter J Pharm Pharm Sci 2018;3:162-6.
13. Madhuri A, Theng GR, Biyani SK. Evaluation of wound healing activity of poly herbal formulation. Int J Curr Pharm Res 2017;9:12-4.
14. Sritharadol R, Nakpheng T, Heng PS, Srichana T. Development of a topical mupirocin spray for antibacterial and wound-healing Applications. Drug Dev Pharm 2017;43:1715-28.
15. Attama AA, Uzor PF, Nnadi CO, Okafor CG. Evaluation of the wound healing activity of gel formulations of leaf extract of Aspila africana Fam. Compositae. J Chem Pharm Res 2011;3:718-72.
16. Ponnekanti K, Rajan RS. Development and validation of New RP-UPLC method for the determination of Cefdinir in bulk and dosage form. Int J Pharm Pharm Sci 2018;1:178-84.
17. Khatri SK, Rathnanand M, Nikhila R. Formulation and evaluation of wound healing activity of Linezolid topical preparations on diabetic rats. Int J Appl Pharm 2016;8:30-6.
Statistics
647 Views | 380 Downloads
Citatons
How to Cite
Srinivasan, U. S. M., V. Vishnu, S. Sharmila, and A. Kumar. “FORMULATION AND EVALUATION OF CEFIXIME TRIHYDRATE TOPICAL GEL FOR WOUND INFECTIONS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, no. 8, Aug. 2018, pp. 369-73, doi:10.22159/ajpcr.2018.v11i8.26150.
Section
Original Article(s)