THE EFFECT OF SAUCE OF L. LEUCOCEPHALA SEEDS (LEUCAENA LEUCOCEPHALA [LAM.] DE WIT) ON LOWERING BLOOD GLUCOSE IN HYPERGLYCEMIC MICE

Authors

  • Sarah Zaidan Department of Pharmacology, Faculty of Pharmacy, University of Pancasila, South Jakarta, Indonesia.
  • Ria Debby Bp Department of Pharmacology, Faculty of Pharmacy, University of Pancasila, South Jakarta, Indonesia.
  • Syamsudin Abdillah Department of Pharmacology, Faculty of Pharmacy, University of Pancasila, South Jakarta, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11s1.26570

Keywords:

Hyperglycemic, Leucaena leucocephala (Lam) de Wit, Alloxan, Sauce

Abstract

 Objective: The research to investigate that the source of Leucaena leucocephala can lower blood glucose levels in hyperglycemic mice.

Methods: In this study, 42 mice were divided into 7 groups each consisted of 6 mice: Normal Group I, Group II (metformin positive control), Group III (negative control), Group IV (sauce of L. leucocephala at a dose of 0.1 ml), Group V (sauce of L. leucocephala at a dose of 0.2 ml), Group VI (sauce of L. leucocephala with doses of 0.4 ml), and Group VII (sauce of L. leucocephala at a dose of 0.8 ml). The dosage of Group II, IV, V, VI, and VII was orally administered. Blood glucose levels in mice were observed during normal conditions and after administration of 200 mg/kg bw alloxan intraperitoneally (alloxan-induced mice). On day 0, 3, 7, and 14, blood was taken from the tail and glucose levels were measured with a glucometer.

Results: Data were analyzed by one-way analysis of variance followed by LSD test. Based on the results, the sauce at a dose of 0.8 ml was able to lower the blood glucose levels up to normal blood glucose levels.

Conclusion: There was not significantly different between the groups given sauce of L. leucocephala at a dose of 0.8 ml with the group given metformin (positive control).

References

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Published

2018-04-26

How to Cite

Zaidan, S., R. Debby Bp, and S. Abdillah. “THE EFFECT OF SAUCE OF L. LEUCOCEPHALA SEEDS (LEUCAENA LEUCOCEPHALA [LAM.] DE WIT) ON LOWERING BLOOD GLUCOSE IN HYPERGLYCEMIC MICE”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 13, Apr. 2018, pp. 70-72, doi:10.22159/ajpcr.2018.v11s1.26570.

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Original Article(s)