THE UTILIZATION OF BINAHONG (ANREDERA CORDIFOLIA (TEN.) STEENIS) LEAF AS AN ANTI‑AGING

Authors

  • Nazliniwaty Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
  • Suryanto Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
  • Desy Damayanti Damanik Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11s1.26575

Keywords:

Binahong, Microemulsion, Anti-aging

Abstract

Objective: To formulate binahong leaf extract in the microemulsion dosage form and to evaluate the anti-aging effect on the human skin.

Methods: Binahong leaf extract was prepared by maceration then formulated into microemulsion dosage form with various concentrations of 0.1%, 0.3%, and 0.5%. The microemulsion preparation was prepared by adding the oil phase to the water phasehen mixed until a clear and transparent microemulsion was formed. Characterization of the dried powder included the determination of water content, water-soluble content, ethanol-soluble content, total ash content, and unsaturated acid ash content. Evaluation of microemulsion preparation included a stability test, determination of homogeneity, density, viscosity, pH, centrifugation, microemulsion type, surface tension, particle size, irritation test, and anti-aging effect test using skin analyzer. Anti-aging parameters measured included moisture, number of spots and wrinkles number.

Results: Characterization results showed the water content of 7.48%, water-soluble content of 19.2%, ethanol soluble content of 9.46%, total ash content of 4.65%, and acid content of 0.58%. Microemulsion preparation of the binahong leaf extract was homogen, had low viscosity, pH 6.0–7.0, density of 1.049–1.0753 g/ml, surface tension of 35.24–38.00 dyne/cm, particle size of 364.68–632.72 nm, stable for 12 weeks storage and did not irritate the skin. The results of anti-aging effect measurements showed that the 0.5% binahong leaf extract microemulsion gave the best results.

Conclusion: The dried powder of binahong leaf is qualified to be formulated. Microemulsion preparation of 0.5% binahong leaf extract showed the best anti-aging effect.

References

Surjanto, Reveny J, Tanuwijaya J, Tias A, Calson. Comparison of anti-aging effect between Vitamin B3 and Provitamin B5 using skin analyzer. Int J Pharm Tech Res 2016;9:99-104.

Draelos ZD, Thaman LA. Cosmetic Formulation of Skin Care Product. New York: Taylor and Francis Group; 2006. p. 167-74.

Katalinic V, Milos M, Kulisic T, Jukic M. Screening of 70 medicinal plant extracts for antioxidant capacity and total phenols. Food Chem 2006;94:550-7.

Sukandar EY, Fidriann I, Adiwibowo LF. Efficacy of ethanol extract of Anredera cordiofilia (Ten) steenis leaves on improving kidney failure in rats. Int J Pharmacol 2011;7:850-1.

Mahdi J. Stability Study of Microemulsion Using Starch Hydrolysate as Stabilizer. Jakarta: FMIPA UI; 2006.

Mazumder J, Pathak D, Kuria R. Evaluation of antacid activity of microemulsion formulation of blend of essential oil. Int J Pharm Sci Drug Res 2015;7:163-7.

Department of Health Republic of Indonesia. Indonesian Materia Medica. 6th ed. Jakarta: Directorate General of Drug and Food Control; 1995.

World Health Organization. Quality Control Methods for Medicinal Plants Material. Switzerland: Geneva Press; 1992.

Anggai R, Hasan H, dan Thomas N. Formulasi dan Evaluasi Sediaan Mikroemulsi Ekstrak Etanol Beras Merah (Oryza nivara) sebagai Antioksidan. Gorontalo: Universitas Negeri Gorontalo; 2013.

Department of Health Republic of Indonesia. Indonesian Pharmacopoeia. 3rd ed. Jakarta: Directorate General of Drug and Food Control; 1979.

Rawlins EA. Bentley’s Textbook of Pharmaceutics. 18th ed. London: Bailierre Tindall; 2003.

Lachman L, Herbert AL, Joseph LK. The Teory and Practice of Industrial Pharmacy. Philadelphia: Lea & Febiger, Michigan University; 1986.

Sudarmadji. Study of Inisiator, Surfactant Types and Monomer Feeding Time on the Pressure Sensitive Adhesive Work with Water Base. Thesis. Jakarta: Material Department Universitas Indonesia; 2012.

Published

2018-04-26

How to Cite

Nazliniwaty, Suryanto, and D. D. Damanik. “THE UTILIZATION OF BINAHONG (ANREDERA CORDIFOLIA (TEN.) STEENIS) LEAF AS AN ANTI‑AGING”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 13, Apr. 2018, pp. 87-89, doi:10.22159/ajpcr.2018.v11s1.26575.

Issue

Section

Original Article(s)