ANTIHYPERURICEMIC ACTIVITY OF ETHANOL EXTRACT OF SYZYGIUM CUMINI LEAVES ON POTASSIUM OXONATED-INDUCED RATS
Keywords:Ethanol extract of Syzygium cumini leaves, Serum uric acid, Potassium oxonate
Objective: This study was conducted to investigate the effect of extract of Syzygium cumini on serum uric acid levels of rats induced by potassium oxonate.
Methods: A total of 30 male Wistar rats were randomly divided into six groups, consist of one normal group (without treatment) and five groups that were induced by potassium oxonate 250 mg/kg bw intraperitoneally for 7 days. The ethanol extract of S. cumini leaves dose (100, 200, and 400 mg/kg bw) was administered orally 1 h after the potassium oxonate exposure during 7 days. On day 8, blood samples were collected for serum uric acid determination.
Result: Ethanol extract of S. cumini leaves at doses of 100 mg/kg bw, 200 mg/kg bw, and 400 mg/kg bw significantly reduced serum uric acid as compared to negative control group of carboxymethylcellulose 0.5%.
Conclusion: Ethanol extract of S. cumini leaves can be used as antihyperuricemic agent.
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