ANTIHYPERURICEMIC ACTIVITY OF ETHANOL EXTRACT OF SYZYGIUM CUMINI LEAVES ON POTASSIUM OXONATED-INDUCED RATS

Authors

  • Mona Asiah Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
  • Rosidah Rosidah Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
  • Yuandani Yuandani Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11s1.26587

Keywords:

Ethanol extract of Syzygium cumini leaves, Serum uric acid, Potassium oxonate

Abstract

Objective: This study was conducted to investigate the effect of extract of Syzygium cumini on serum uric acid levels of rats induced by potassium oxonate.

Methods: A total of 30 male Wistar rats were randomly divided into six groups, consist of one normal group (without treatment) and five groups that were induced by potassium oxonate 250 mg/kg bw intraperitoneally for 7 days. The ethanol extract of S. cumini leaves dose (100, 200, and 400 mg/kg bw) was administered orally 1 h after the potassium oxonate exposure during 7 days. On day 8, blood samples were collected for serum uric acid determination.

Result: Ethanol extract of S. cumini leaves at doses of 100 mg/kg bw, 200 mg/kg bw, and 400 mg/kg bw significantly reduced serum uric acid as compared to negative control group of carboxymethylcellulose 0.5%.

Conclusion: Ethanol extract of S. cumini leaves can be used as antihyperuricemic agent.

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Published

2018-04-26

How to Cite

Asiah, M., R. Rosidah, and Y. Yuandani. “ANTIHYPERURICEMIC ACTIVITY OF ETHANOL EXTRACT OF SYZYGIUM CUMINI LEAVES ON POTASSIUM OXONATED-INDUCED RATS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 13, Apr. 2018, pp. 132-4, doi:10.22159/ajpcr.2018.v11s1.26587.

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