EFFECT OF ETHANOL EXTRACT OF PICRIA FEL-TERRAE LOUR. LEAVES ON TRIGLYCERIDE AND CHOLESTEROL LEVELS OF WHITE RATS

Urip Harahap; Marianne; Yuandani; Hafiza Mitha Agustya; Dira Ummul Azizah; Syari Widia Alfiah

doi:10.22159/ajpcr.2018.v11s1.26618

Authors

Urip Harahap Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, 5 Jalan Almamater, USU-Kampus, Medan 20155, Indonesia.
Marianne Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, 5 Jalan Almamater, USU-Kampus, Medan 20155,Indonesia.
Yuandani Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, 5 Jalan Almamater, USU-Kampus, Medan 20155,Indonesia.
Hafiza Mitha Agustya Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, 5 Jalan Almamater, USU-Kampus, Medan 20155, Indonesia.
Dira Ummul Azizah Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, 5 Jalan Almamater, USU-Kampus, Medan 20155, Indonesia.
Syari Widia Alfiah Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, 5 Jalan Almamater, USU-Kampus, Medan 20155, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11s1.26618

Keywords:

Picria fel-terrae, Triglyceride, Cholesterol

Abstract

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Â Objective: The objective of the study was to evaluate the effect of Picria fel-terrae on triglyceride and cholesterol levels in long-term duration.

Methods: The effect of ethanol extract of P. fel-terrae leaves was performed using white rats divided into several groups, which include control group, extract at doses of 125, 250, 500, and 1000 mg/kg body weight. The extract at different doses was orally administered to the test animal for 90 days. Then, the triglyceride and cholesterol levels were measured.

Results: The ethanol extract of P. fel-terrae in long-term use did not affect the cholesterol level of male and female white rats. However, there was a significant increased in triglyceride level as compared to normal control (p<0.05).

Conclusion: The ethanol extract of P. fel-terrae increased triglyceride level only without increasing the level of cholesterol.

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