EFFECT OF ETHANOL EXTRACT OF PICRIA FEL-TERRAE LOUR. LEAVES ON TRIGLYCERIDE AND CHOLESTEROL LEVELS OF WHITE RATS

Authors

  • Urip Harahap Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, 5 Jalan Almamater, USU-Kampus, Medan 20155, Indonesia.
  • Marianne Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, 5 Jalan Almamater, USU-Kampus, Medan 20155,Indonesia.
  • Yuandani Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, 5 Jalan Almamater, USU-Kampus, Medan 20155,Indonesia.
  • Hafiza Mitha Agustya Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, 5 Jalan Almamater, USU-Kampus, Medan 20155, Indonesia.
  • Dira Ummul Azizah Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, 5 Jalan Almamater, USU-Kampus, Medan 20155, Indonesia.
  • Syari Widia Alfiah Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, 5 Jalan Almamater, USU-Kampus, Medan 20155, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11s1.26618

Keywords:

Picria fel-terrae, Triglyceride, Cholesterol

Abstract

 

 Objective: The objective of the study was to evaluate the effect of Picria fel-terrae on triglyceride and cholesterol levels in long-term duration.

Methods: The effect of ethanol extract of P. fel-terrae leaves was performed using white rats divided into several groups, which include control group, extract at doses of 125, 250, 500, and 1000 mg/kg body weight. The extract at different doses was orally administered to the test animal for 90 days. Then, the triglyceride and cholesterol levels were measured.

Results: The ethanol extract of P. fel-terrae in long-term use did not affect the cholesterol level of male and female white rats. However, there was a significant increased in triglyceride level as compared to normal control (p<0.05).

Conclusion: The ethanol extract of P. fel-terrae increased triglyceride level only without increasing the level of cholesterol.

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References

Nirosha KK, Divya M, Vamsi S, Sadiq M. A review on hyperlipidemia. Int J Novel Trends Pharm Sci 2014;4:81-92.

Shattat GF. A review article on hyperlipidemia: Types, treatments and new drug targets. Biomed Pharmacol J 2014;7:399-409.

Marianne, Chrestella J, Ginting MA, Dalimunthe A, Nasution R. Hepatoprotective activity combination of Curanga fel-terrae Lou leaves and Curcuma heyneana valeton and zijprhizome in rat induced by a combination of rifampin and isoniazid. Int J Pharm Pharm Sci 2017;9:23-8.

Lindarto D, Syafril S, Zein U, Saragih A. The effect of dhawalsan-1 (Curanga fel-terrae [Lour.]) extract versus metformin on the metabolic and inflammatory characteristics of patients with newly diagnosed Type 2 diabetes mellitus. Asian J Pharm Clin Res 2016;9 Suppl 1:225- 8.

Dalimunthe A, Harahap U, Rosidah, Nasution MP. Evaluation of diuretic activity of Picria fel-terrae Lour leaves extracts. Asian J Pharm Clin Res 2015;8:204-5.

Juwita NA, Harahap U, Dalimunthe A. Relaxation effect of ethanolic extract of Picria fel-terrae (Pugon tanoh) leaves on contraction of isolated rat’s ileum contracted by serotonin. J Innov Pharm Biol Sci 2018;5:37-41.

OECD. Repeated Dose 90-day Oral Toxicity Study in Rodents TG No. 408; 2008.

Gupta D, Bhardwaj S. Study of acute, subacute and chronic toxicity test. Int J Adv Res Pharm Bio Sci 2012;1:103-14.

Hastuti US. The influence of various dosages of citrinin on hepatocyte structure mice (Mus Musculus) damage to three lobulus hepar zone. J Kedokteran Brawijaya 2006;22: ???.

Dalimunthe, A. Evaluation of effect of n-hexane fraction, ethyl acetate and ethanol leaf Poguntano (Picria fel terrae Lour.) againts cardiovascular system. Disertasi. Medan: Fakultas Farmasi USU; 2006.

Nirwana GI. Subcronic Toxixity Ethanol Extract of Magican Fruit Skin (Gracia mangostana) against Rat Hepar Cells (Rattus norvegicus) Wistar Strain. Thesis. Medical School: Universitas Malang; 2014.

Published

26-04-2018

How to Cite

Harahap, U., Marianne, Yuandani, H. M. Agustya, D. U. Azizah, and S. W. Alfiah. “EFFECT OF ETHANOL EXTRACT OF PICRIA FEL-TERRAE LOUR. LEAVES ON TRIGLYCERIDE AND CHOLESTEROL LEVELS OF WHITE RATS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 13, Apr. 2018, pp. 243-4, doi:10.22159/ajpcr.2018.v11s1.26618.

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