CARBON NANOTUBE: A FLEXIBLE APPROACH FOR NANOMEDICINE AND DRUG DELIVERY
Nanostructures of carbon were first observed in 1952, which gained worldwide interest due to their various physicochemical properties. Carbon
nanotubes (CNTs) have found wide applications in the delivery of therapeutic agents such as peptides, proteins, siRNA, nucleic acids, genes, vaccines
and also in bone and neural tissue regeneration. Functionalized CNTs have found to be biocompatible. The eye-catching features of these structures
are their electronic, mechanical, optical and chemical characteristics, which open a way to future applications and make them good candidates for
a wide variety of applications, including drug transporters, new therapeutics, delivery systems and diagnostics. Their unique surface area, stiffness,
strength, and resilience have led to much excitement in the field of pharmacy. They can pass through membranes, carrying therapeutic drugs, vaccines,
and nucleic acids deep into the cell to targets that are previously unreachable. The applications of carbon nanotubes are in tissue engineering,
drug carrier release system, wound healing, in cancer treatment and as biosensor. The successful realization of CNT-based biosensors requires
proper control of their chemical and physical properties, as well as their functionalization and surface immobilization. Real applications are still
under development. The modifications are done to improve efficiency of carbon nanotubes by formulating luminescent carbon nanotubes, ultrathin
carbon nano-needles, magnetically guided nanotubes. Researchers have recently developed a new approach to boron neutron capture therapy in the
treatment of cancer using substituted carborane-appended water-Soluble single-wall carbon nanotubes. This article provides an overview of current
nanotube technology, with a special focus on synthesis and purification, properties, benefits, and applications.
Keywords: Carbon nanotubes, Biosensors, Tissue engineering, Biocompatible.
Wang X, Li Q, Xie J, Jin Z, Wang J, Li Y, et al. Fabrication of ultralong
and electrically uniform single-walled carbon nanotubes on clean
substrates. Nano Lett 2009;9(9):3137-41.
Wang H, Chhowalla M, Sano N, Jia S, Amaratungal GA. Large
scale synthesis of single walled carbon nanohorn by submerged arc.
Yu MF, Lourie O, Dyer MJ, Moloni K, Kelly TF, Ruoff RS. Strength
and breaking mechanism of multiwalled carbon nanotubes under tensile
load Science 2000;287:637-40.
Collins PG. Nanotubes for Electronics. Scientific American; 2000.
Jensen K, Mickelson W, Kis A, Zettl A. Buckling and kinking force
measurements on individual multiwalled carbon nanotubes. Phys Rev
Popov M, Kyotani M, Nemanich RJ, Koga Y. Superhard phase
composed of single wall carbon nanotube. Phys Rev 2000;B65:033408.
Hone J. Phonons and thermal properties of carbon nanotubes. Appl
Yi W, Lu L, Zhang DL, Pan ZW, Xie SS. Linear specific heat of carbon
nanotubes. Phys Rev B 1999;59:9015.
Mizel A, Benedict LX, Cohen ML, Louie SG, Zettl A, Budraa NK, et al.
Analysis of the low-temperature specific heat of multiwalled carbon
nanotubes and carbon nanotube ropes. Phys Rev B 1999;60:3264.
Hone J, Batlogg B, Benes Z, Johnson AT, Fischer JE. Quantized phonon
spectrum of single- wall carbon nanotubes. Science 2000;289:1730.
Lasjaunias JC, BiljakoviÃ¦ K, Benes Z, Fischer JE, Monceau P. Lowtemperature
specific heat of single-wall carbon nanotubes. Phys Rev B
Hone J, Whitney M, Piskoti C, Zettl A. Thermal conductivity of singlewalled
carbon nanotubes. Phys Rev B 1999;59:2514.
Kim P, Shi L, Majumdar A, McEuen PL. Thermal transport
measurements of individual multiwalled nanotubes. Phys Rev Lett
Anazawa K, Shimotani K, Manabe C, Watanabe H, Shimizu M. High
purity carbon nano tube synthesis method. Appl Phys Lett 2002;81:739-41.
Bianco A, Kostarelos K, Partidos CD, Prato M. Biomedical applications
of functionalised carbon nanotubes. Chem Commun (Camb)
Bianco A, Hoebeke J, Kostarelos K, Prato M, Partidos CD. Carbon
nanotubes: On the road to deliver. Curr Drug Deliv 2005;2(3):253-9.
Moore V, Strano M, Haroz E, Hauge R, Smalley R. Individually
suspended single-walled carbon nanotubes in various surfactants. Nano
Vaisman L, Wagner HD, Marom G. The role of surfactants in dispersion
of carbon nanotubes. Adv Colloid Interface Sci 2006;128-130:37-46.
Fernando KA, Lin Y, Sun YP. High aqueous solubility of functionalized
single-walled carbon nanotubes. Langmuir 2004;20(11):4777-8.
Saini RK, Chiang IW, Peng H, Smalley RE, Billups WE, Hauge RH,
et al. Covalent sidewall functionalization of single wall carbon
nanotubes. J Am Chem Soc 2003;125(12):3617-21.
Kim BM, Qian S, Bau HH. Filling carbon nanotubes with particles.
Nano Lett 2005;5(5):873-8.
Abdulkareem AS, Afolabi AS, Iyuke SE, Vz Pienaar HC. Synthesis
of carbon nanotubes by swirled floating catalyst chemical vapour
deposition method. J Nanosci Nanotechnol 2007;7(9):3233-8.
Eklund P, Holden J, Jishi R. Vibrational modes of carbon nanotubes;
spectroscopy and theory. Carbon 1995;33:959-72.
Yinghuai Z, Peng AT, Carpenter K, Maguire JA, Hosmane NS,
Takagaki M. Substituted carborane-appended water-soluble single-wall
carbon nanotubes: New approach to boron neutron capture therapy drug
delivery. J Am Chem Soc 2005;127(2):9875-80.
Hirlekar R, Yamagar M, Garse H, Vij M, KadamV. Carbon nanotubes
and its applications. Asian J Pharm Clin Res 2009;2(4):24-6.
How to Cite
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.