ANTIDIABETIC AND INSULIN SENSITIZING EFFECTS OF PADINA PAVONIA AND TURBENARIA ORNATA IN STREPTOZOTOCIN/NICOTINAMIDE DIABETIC RATS

  • Ayman Mahmoud
  • Mousa O. Germoush
  • Hassan A. Elgebaly
  • Khaled N.m. Elsayed
  • Sherif Hassan
  • Nermeen M. Mousa
  • Omnia E. Hussein

Abstract

Objective:The current study was designed to investigate the hypoglycemic, hypolipidemic and insulin sensitizing effects of two marine brown algae, Padinapavoniaand Turbenariaornata.

Materials and methods:Type 2 diabetes was induced by intraperitoneal injection of 120 mg/kg b.wt. nicotinamide 30 minutes before injection of 50 mg/kg b.wt. streptozotocin. Extracts of both Padinapavoniaand Turbenariaornata were orally and daily administered at a dose level of 100 mg/kg b.wt. for 21 days to diabetic rats. At the end of the experimental period, blood, pancreas and adipose tissue samples were taken for the subsequent studies.

Results:Both Padinapavoniaand Turbenariaornata supplementation potentially ameliorated the elevated levels of glucose, AST, LDH and CK-MB and the lowered serum insulin levels of type 2 diabetic rats. Also, the tested algae increased the β-cell number in pancreata of diabetic rats. Both extracts were also found to alleviate the altered lipid profile and serum adiponectin level as well as the insulin resistance indices, HOMA-IR and QUICKI. In addition, both algae significantly upregulated adipose tissue adiponectin mRNA expression.

Conclusion: These experimental findings demonstrated that both Padinapavoniaand Turbenariaornata exhibit antidiabetic effects in a rat model of type 2 diabetes by their insulinotropic and insulin sensitizing effects.

Key Words: Adiponectin, insulin resistance, brown algae, diabetes.

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How to Cite
Mahmoud, A., M. O. Germoush, H. A. Elgebaly, K. N. Elsayed, S. Hassan, N. M. Mousa, and O. E. Hussein. “ANTIDIABETIC AND INSULIN SENSITIZING EFFECTS OF PADINA PAVONIA AND TURBENARIA ORNATA IN STREPTOZOTOCIN/NICOTINAMIDE DIABETIC RATS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 7, no. 4, Sept. 2014, pp. 72-78, https://innovareacademics.in/journals/index.php/ajpcr/article/view/2743.
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