ANTIDIABETIC AND INSULIN SENSITIZING EFFECTS OF PADINA PAVONIA AND TURBENARIA ORNATA IN STREPTOZOTOCIN/NICOTINAMIDE DIABETIC RATS

  • AYMAN M MAHMOUD
  • MOUSA O GERMOUSH
  • HASSAN A ELGEBALY
  • KHALED NM ELSAYED
  • SHERIF HASSAN
  • NERMEEN M MOUSA
  • OMNIA E HUSSEIN

Abstract

Objective:The current study was designed to investigate the hypoglycemic, hypolipidemic and insulin sensitizing effects of two marine brown algae, Padinapavoniaand Turbenariaornata.

Materials and methods:Type 2 diabetes was induced by intraperitoneal injection of 120 mg/kg b.wt. nicotinamide 30 minutes before injection of 50 mg/kg b.wt. streptozotocin. Extracts of both Padinapavoniaand Turbenariaornata were orally and daily administered at a dose level of 100 mg/kg b.wt. for 21 days to diabetic rats. At the end of the experimental period, blood, pancreas and adipose tissue samples were taken for the subsequent studies.

Results:Both Padinapavoniaand Turbenariaornata supplementation potentially ameliorated the elevated levels of glucose, AST, LDH and CK-MB and the lowered serum insulin levels of type 2 diabetic rats. Also, the tested algae increased the β-cell number in pancreata of diabetic rats. Both extracts were also found to alleviate the altered lipid profile and serum adiponectin level as well as the insulin resistance indices, HOMA-IR and QUICKI. In addition, both algae significantly upregulated adipose tissue adiponectin mRNA expression.

Conclusion: These experimental findings demonstrated that both Padinapavoniaand Turbenariaornata exhibit antidiabetic effects in a rat model of type 2 diabetes by their insulinotropic and insulin sensitizing effects.

Key Words: Adiponectin, insulin resistance, brown algae, diabetes.

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How to Cite
M MAHMOUD, A., M. O. GERMOUSH, H. A. ELGEBALY, K. N. ELSAYED, S. HASSAN, N. M. MOUSA, and O. E. HUSSEIN. “ANTIDIABETIC AND INSULIN SENSITIZING EFFECTS OF PADINA PAVONIA AND TURBENARIA ORNATA IN STREPTOZOTOCIN/NICOTINAMIDE DIABETIC RATS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 7, no. 4, Sept. 2014, pp. 72-78, https://innovareacademics.in/journals/index.php/ajpcr/article/view/2743.
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