PREPARATION, EVALUATION, AND CLINICAL APPLICATION OF SAFFLOWER CREAM AS TOPICAL NUTRITIVE AGENT

  • Ibtihal Abdulkadhim Dakhil Department of Pharmaceutical, College of Pharmacy, University of Mustansiriyah, Baghdad, Iraq. http://orcid.org/0000-0002-6118-5702
  • Ibrahim S Abbas Department of Pharmacognsy, College of Pharmacy, University of Mustansiriyah, Baghdad, Iraq.
  • Nidhal K Marie Department of Pharmaceutical, College of Pharmacy, University of Mustansiriyah, Baghdad, Iraq.

Abstract

Objective: The objective of this study was to formulate and evaluate safflower seeds oil as herbal nutritive skin cream and to study its clinical effect.

Methods: After collecting the safflower seeds, the oil was extracted using an expeller or cold pressing. Physical parameters of oil were determined. Determination of unsaturated fatty acids was done by gas-liquid chromatography (GLC). The oil is then placed in an emulsifier to form cream using various additives and all formulas evaluated according to physical properties, PH, and viscosity.

All symptoms such as skin damage by sunlight, skin aging, oxidative damage after sunburn or after chemical treatments, all of these conditions have recovered. Statistical data analysis was carried out using Statistical Analysis System, and all recorded data for analysis of variance and least significant difference were at least the significant difference at level 0.01.

Results: The results of the GLC analysis indicated that safflower oil contains five different fatty acids, including linoleic acid (56.37%), linolenic acid (15.02%), stearic acid (2.37%), oleic acid (14.83%), and palmitic acid (7.91%).

Refractive index values, density, and specific gravity were 1.476, 0.921 g/cm3, and 0.925, respectively.

The results of a clinical study showed the effect of safflower cream as an antioxidant which protected the skin in particular from oxidative damage after sunburn and reduced the symptoms of skin aging. This effect was evident in both concentrations 10% and 15% when compared with control.

Control response rate, 10% of safflower cream, and 15% of safflower cream were reached to 76%, 85%, and 92% within 2 weeks of treatment, respectively.

Conclusion: The study showed the importance of safflower oil as a source of omega-3 and contains various unsaturated fatty acids which act as an antioxidant to restore skin health and aging resistance. This study approved that safflower oil characteristics can make it the main ingredients in the preparation of topical agents for the treatment of various skin problems.

Keywords: Safflower, Clinical application, Nutritive.

Author Biography

Ibtihal Abdulkadhim Dakhil, Department of Pharmaceutical, College of Pharmacy, University of Mustansiriyah, Baghdad, Iraq.

pharmaceutics department

assistant lecturer

References

1. Jolene H. Eat Prity: Nutrition for Beauty, Inside and Out. China; 2014.
2. World Health Organization. Dept of Child and Adolescent Health and Development. Epidemiology and Management of Common Skin Diseases in Children in Developing Countries. Geneva; 2005. Available from: http://www.who.int/iris/handle/10665/69229.
3. Bocca B, Pino A, Alimonti A, Forte G. Toxic metals contained in cosmetics: A status report. Regul Toxicol Pharmacol 2014;68:447-67.
4. Boelsma E, Hendriks HF, Roza L. Nutritional skin care: Health effects of micronutrients and fatty acids. Am J Clin Nutr 2001;73:853-64.
5. Dania FA, IbrahimS A, Ashour HD. Invistigation of the main alkaloid of London rocket (Sisymbrium irio L.) as a wild medicinal plant grown in Iraq. Int J Pharm Sci Rev Res 2016;39:279-81.
6. Baümler E, Fernández MB, Nolasco SM, Pérez EE. Comparision of safflower oil extraction kinetics under two characteristics moisture conditions statistical analysis of non-linear model parameters. Braz J Chem Eng 2014;31:553-9.
7. Shahid A, Asma R, Habib R, Shakil M. Phytochemical and biological screening of Ricinus communis seed oil grown wild in Jammn and Kashmir. J Pharm Phytochem 2016;5:89-92.
8. Sruthi BK, Gurupadayya BM, Sairam KV, Kumar TN. Development and validation of GC method for the estimation of eugenol in clove extract. Int J Pharm Pharm Sci 2014;6:473-6.
9. Mishra A, Saklani S, Milella L, Tiwari P. Formulation and evaluation of herbal antioxidant face cream of Nardostachys jatamansi collected from Indian Himalayan region. Asian Pac J Trop Biomed 2014;4:679-82.
10. Ibrahim SA, Mohammed JH, Ali HM. Analysis with evaluation of drying temperature on essential oil content of Achillea frayrantissima L. and Artemisia herb-alba L. Int J Pharm Pharm Sci 2013;5:913-4.
11. Muthukumarasamy R, Ilyana A, Fithriyaani NA, Najihah NA, Asyiqin N, Seka M. Formulation and evaluation of natural antioxidant cream comprising methanolic peel extract of Dimocarpus longan. Int J Pharm Clin Res 2016;8:1305-9.
12. Uganda RE, Deivi SK. Formulation and evaluation of natural palm oil based vanishing cream. Int J Pharm Sci Res 2013;4:3375-80.
13. Fair PH, Fortner AR. The role of formula feeds and natural productivity in culture of the prawn, Macrobrachium rosenbergii. Aquac Int J 1981;24:233-43.
14. Nair SS, Mathew M, Sreena K. Formulation and evaluation of herbal cream containing Curcuma longa. Int J Pharm Chem Sci 2012;1:1362-8.
15. Black HS, Rhodes LE. The potential of omega-3 fatty acids in the prevention of non-melanoma skin cancer. Cancer Detect Prev 2006;30:224-32.
16. MaraieNK, Abdul-Jali TZ, Alhamdany AT, JanabiH A. Phytochemical study of the Iraqi Beta vulgaris leaves and its clinical applications for treatment of different dermatological diseases. World J Pharm Pharm Sci 2014;3:5-19.
Statistics
191 Views | 449 Downloads
Citatons
How to Cite
Dakhil, I. A., I. S. Abbas, and N. K. Marie. “PREPARATION, EVALUATION, AND CLINICAL APPLICATION OF SAFFLOWER CREAM AS TOPICAL NUTRITIVE AGENT”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, no. 8, Aug. 2018, pp. 495-7, doi:10.22159/ajpcr.2018.v11i8.27431.
Section
Original Article(s)