COMPARATIVE STUDY OF LEVELS OF SELECTIVE OXIDATIVE STRESS MARKERS (MALONDIALDEHYDE, ZINC, AND ANTIOXIDANT VITAMINS A, E, AND C) IN ISCHEMIC AND NON-ISCHEMIC HEART DISEASE PATIENTS SUFFERING FROM TYPE- 2 DIABETES

  • Abd Elgadir A Altoum Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, UAE.
  • Ahmed L Osman Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, UAE.
  • Asaad Ma Babker Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, UAE.

Abstract

Objective: The objective of the current study is to compare the levels of oxidative stress markers malondialdehyde (MDA), zinc, and antioxidant Vitamins (A, E, and C) in ischemic heart disease (IHD) and non-IHD patients with diabetes mellitus.

Method: This is cross-sectional study group, conducted in the advanced diagnostic center (Khartoum- Sudan) from the period May 2013 to August 2015. Comprised 100 healthy subjects were, control group with mean (fasting blood sugar) 5.61=m mol/L, the age ranged from 22 to 78 years old, the average of the age was 50.1 years. 300 patients (78 IHD and 222 without) as cases groups, the ages ranged from 30 to 80 years. The age average was 51.2 years, all samples were in a state of fasting for 12 h, and the data were collected using a structured questionnaire and direct interview to collect information. Blood specimens were collected from both groups, and plasma levels of MDA, zinc, and antioxidant Vitamins (A, E, and C) were determined.

Results: There was a significant difference between the level of serum Vitamin A, E, and MDA in diabetic patients with IHD and those diabetic without IHD (p<0.05). No significant differences in serum Vitamin C level between both groups (p>0.05).

Conclusion: Due to the significant differences in serum Vitamin A, E, Zinc, and MDA between diabetics with IHD and diabetics without IHD, these parameters can be used as prognostic markers for prediction of oxidative stress and antioxidant stress of diabetic patients with IHD complications.

Keywords: Diabetes mellitus, Ischemic heart disease, Malondialdehyde, Zinc, Vitamin C, E, and A.

References

1. Jayesh BD, Snehal NM, Archana RJ. Diabetic nephropathy–genesis, prevention and treatment. Int J Pharm Pharm Sci 2014;6:42-7.
2. World Health Organization. Global Report on Diabetes. Geneva: World Health Organization; 2016.
3. Bartels DW, Davidson MH, Gong WC. Type 2 diabetes and cardiovascular disease: Reducing the risk. J Manag Care Spec Pharm 2007;13:1-7.
4. Kayama Y, Raaz U, Jagger A, Adam M, Schellinger IN, Sakamoto M, et al. Diabetic cardiovascular disease induced by oxidative stress. Int J Mol Sci 2015;23:25234-63.
5. Dresslerova I, Vojacek J. Diabetes mellitus and ischemic heart disease.
Vnitrni Lekarstvi 2010;56:301-6.
6. Singh K, Sukhjit K, Rajiv A. status of certain oxidative stress markers in ischemic heart disease patients with and without smoking in north Indian Punjabi population. Br Biomed Bull 2015;3:225-31.
7. Elgadir AA, Ahmed LO, Ma BA. Correlation of oxidative stress markers malondialdehyde (MDA), antioxidant vitamins A, E, and C with glycated hemoglobin (HBA1C) levels in Type 2 diabetes mellitus. Asian J Pharm Clin Res 2018;5:281-3.
8. Shahid SU, Humphries S. The SNP rs10911021 is associated with oxidative stress in coronary heart disease patients from Pakistan. Lipids Health Dis 2018;17:6.
9. Khan MA, Baseer A. Increased malondialdehyde levels in coronary heart disease. J Pak Med Assoc 2000;50:261-4.
10. Najah AL, Al-kaissi E, Muhi-eldeen ZA, Arafat TA, AL-Muhtaseb SI. Oxidants and antioxidants as risk factors in young Arabian male patients with acute myocardial infarction. Int J Pharm Pharm Sci 2016;8:273-7.
11. Yıldıran H, Mercanlıgil SM, Besler HT, Tokgözoğlu L, Kepez A. Serum antioxidant vitamin levels in patients with coronary heart disease. Int J Vitam Nutr Res 2011;81:211-7.
12. Schroder S. Is supplementation with antioxidants effective in the treatment of atherosclerosis? Med Wochenschr 2004;129:321-6.
13. Riccioni G, Frigiola A, Pasquale S, de Massimo G, D’Orazio N. Vitamin C and E consumption and coronary heart disease in men. Front Biosci 2012;4:373-80.
14. Rajasekhar D, Rao PS, Latheef SA, Saibaba KS, Subramanyam G. Association of serum antioxidants and risk of coronary heart disease in South Indian population. Indian J Med Sci 2004;58:465.
15. Dube A, Khalsa A, Gupta SK, Singh U, Sharma P. Serum tocopherol and lipids in patients with coronary artery disease. Ind Heart J 1998;50:292-4.
16. Randall A, Swain, Machlis BK, Pharma D. Therapeutic uses of vitamin E in prevention of atherosclerosis. Altern Med Rev 1999;4:414-23.
17. Moser MA, Chun OK. Vitamin C and heart health: A review based on findings from epidemiologic studies. Int J Mol Sci 2016;17:1328.
18. Lee DH, Folsom AR, Harnack L, Halliwell B, Jacobs DR. Does supplemental vitamin C increase cardiovascular disease risk in women with diabetes? Am J Clin Nutr 2004;80:1194-200.
19. Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC, USA: The National Academies Press; 2000.
20. Desai CK, Huang J, Lokhandwala A, Fernandez A, Riaz IB, Alpert JS. The role of vitamin supplementation in the prevention of cardiovascular disease events. Clin Cardiol 2014;37:576-81.
21. Yu X, Huang L, Zhao J, Wang Z, Yao W, Wu X, et al. The relationship between serum zinc level and heart failure: A Meta-analysis. Biomed Res Int 2018;2018:2739014.
22. Demirbag R, Yilmaz R, Erel O, Gultekin U, Asci D, Elbasan Z, et al. The relationship between potency of oxidative stress and severity of dilated cardiomyopathy. Can J Cardiol 2005;21:851-5.
23. Soinio M, Marniemi J, Laakso M, Pyörälä K, Lehto S, Rönnemaa T, et al. Serum zinc level and coronary heart disease events in patients with Type 2 diabetes. Diabetes Care 2007;30:523-8.
24. Almzaiel AJ. Oxidative stress and inflammation in ischemic heart disease: Role of trace elements, oxidants and antioxidants. J Contemp Med Sci 2015;1:18-27.
25. Shekokar DP, Kaundinya D. Effect of acute myocardial infarction on serum zinc level. Indian J Basic Appl Med Res 2013;3:80-7.
Statistics
235 Views | 225 Downloads
Citatons
How to Cite
A Altoum, A. E., A. L. Osman, and A. M. Babker. “COMPARATIVE STUDY OF LEVELS OF SELECTIVE OXIDATIVE STRESS MARKERS (MALONDIALDEHYDE, ZINC, AND ANTIOXIDANT VITAMINS A, E, AND C) IN ISCHEMIC AND NON-ISCHEMIC HEART DISEASE PATIENTS SUFFERING FROM TYPE- 2 DIABETES”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, no. 8, Aug. 2018, pp. 508-10, doi:10.22159/ajpcr.2018.v11i8.27772.
Section
Original Article(s)