• Jampala Rajkumar Department of Pharmaceutics, Gitam Institute of Pharmacy, Gitam (Deemed to be University), Rushikonda, Visakhapatnam - 530 045, Andhra Pradesh, India.
  • Radha Gv Department of Pharmaceutics, Gitam Institute of Pharmacy, Gitam (Deemed to be University), Rushikonda, Visakhapatnam - 530 045, Andhra Pradesh, India.
  • Trideva Sastri K Department of Pharmaceutics, Gitam Institute of Pharmacy, Gitam (Deemed to be University), Rushikonda, Visakhapatnam - 530 045, Andhra Pradesh, India.
  • Sadhana Burada Department of Pharmaceutics, Gitam Institute of Pharmacy, Gitam (Deemed to be University), Rushikonda, Visakhapatnam - 530 045, Andhra Pradesh, India.


An existence of transdermal delivery tool, proniosomal gel, has established to showed remarkable development for lipophilic/hydrophilic drugs over additional formulations. Newer drugs of lipophilic nature emerge poor bioavailability, irregular absorption, and pharmacokinetic changes. Therefore, this novel drug delivery system has been proved advantageous over other oral and topical delivery of drug candidates to bypass such disruption. This proniosomal gel basically is a compact semi-solid liquid crystalline (gel) composed of non-ionic surfactants easily formed on dissolving the surfactant in a minimal amount of acceptable solvent and the least amount of aqueous phase and phosphate buffer. Topical application of gel under occlusive condition during which they are converted into nisomes due to hydration by water in the skin present itself. Proniosomal gels are typically present in transparent, translucent, or white semisolid gel texture, which makes them physically stable throughout storage and transport. This review provides an important overview of the preparation, formulation, evaluation, and application of proniosome gel as a drug delivery carrier.

Keywords: Vesicular drug delivery, Proniosomal gel, Non-ionic surfactants, Coacervation phase separation, Topical drug delivery.

Author Biography

Jampala Rajkumar, Department of Pharmaceutics, Gitam Institute of Pharmacy, Gitam (Deemed to be University), Rushikonda, Visakhapatnam - 530 045, Andhra Pradesh, India.




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How to Cite
Rajkumar, J., R. Gv, T. Sastri K, and S. Burada. “RECENT UPDATE ON PRONIOSOMAL GEL AS TOPICAL DRUG DELIVERY SYSTEM”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 1, Jan. 2019, pp. 54-61, doi:10.22159/ajpcr.2019.v12i1.28558.
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