ENHANCEMENT OF THE SOLUBILITY AND THE DISSOLUTION RATE OF TAMOXIFEN CITRATE SOLID DISPERSION USING SOLUPLUS BY SOLVENT EVAPORATION TECHNIQUE

  • Hayder Hussein Abduljabbar Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Iraq.
  • Shaimaa Nazar Abd Alhammid Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Iraq.

Abstract

Objective: The aim of the present study was the enhancement in the solubility of tamoxifen citrate using solid dispersion which is considered as a great solution to overcome the poor water solubility behavior of tamoxifen citrate (TMX) by solvent evaporation technique using Soluplus® as a novel carrier then formulate it as an orodispersible tablet.

Method: A total of 24 formulas were prepared as a solid dispersion by solvent evaporation method using Soluplus® as a polymeric solubilizer in the ratio of 1:1, 1:3, 1:5, 1:7, and 1:10 then formulated as orodispersible tablets by incorporating three types of superdisintegrants; croscarmellose, crospovidone, and sodium starch glycolate (SSG) with the solid dispersion. Characterization of the formulation was done using differential scanning colorimetry, Fourier transforms infrared spectroscopy, X-ray diffraction, and scanning electron microscope and the best formula was selected according to the disintegration and dissolution tests.

Results and Discussion: Formula 22 were selected as the best formula which contains mixed types of superdisintegrants; croscarmellose and SSG with the fastest complete disintegration of 6.5 s and complete dissolution with <2 min.

Conclusion: Accordingly, TMX was successfully enhanced its water solubility by converting its crystalline structure into the amorphous state through solid dispersion with Soluplus® and formulated as an orodispersible tablet to improve its oral absorption.

Keywords: Tamoxifen citrate, Solid dispersion, Soluplus®, Orodispersible tablet, Superdisintegrants.

Author Biographies

Hayder Hussein Abduljabbar, Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Iraq.
College of Pharmacy University of Baghdad Iraq
Shaimaa Nazar Abd Alhammid, Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Iraq.
College of Pharmacy University of Baghdad Iraq

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How to Cite
Abduljabbar, H. H., and S. N. Abd Alhammid. “ENHANCEMENT OF THE SOLUBILITY AND THE DISSOLUTION RATE OF TAMOXIFEN CITRATE SOLID DISPERSION USING SOLUPLUS BY SOLVENT EVAPORATION TECHNIQUE”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 1, Jan. 2019, pp. 216-21, doi:10.22159/ajpcr.2019.v12i1.28933.
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